Harper's Biochemistry 25th Edition (Lange Series) / Edition 25

Harper's Biochemistry 25th Edition (Lange Series) / Edition 25

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by Appleton & Lange, Daryl K. Granner, Victor W. Rodwell, Peter A. Mayes
     
 

The overall objective of this silver edition of Harper's Biochemistry is to provide concise yet authoritative coverage of the principles of biochemistry and molecular biology. The text offers numerous examples of how knowledge of biochemistry is essential for understanding the maintenance of health and the causes and rational treatment of many

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Overview

The overall objective of this silver edition of Harper's Biochemistry is to provide concise yet authoritative coverage of the principles of biochemistry and molecular biology. The text offers numerous examples of how knowledge of biochemistry is essential for understanding the maintenance of health and the causes and rational treatment of many diseases.

Features:

  • Covers the fundamentals of biochemistry in a relevant interesting manner
  • Contains information on prevalent medical conditions, including hypercholesterolemia, obesity, osteoporosis, and diabetes mellitus
  • Covers new developments in metabolism and genetics, including the Human Genome Project and the genetic basis of hemochromatosis
  • Presents hundreds of colorful images to help students visualize new information

The book is divided into three introductory chapters followed by six main sections. Section I deals with proteins and enzymes, the workhorses of the body. Because enzymes catalyze most reactions in the human body, it is vital to understand the properties of enzymes before moving on to other topics. Section II explains how various cellular reactions either utilize or produce energy and traces the pathways by which carbohydrates and lipids are synthesized and degraded. The many functions of these two classes of molecules are also described. Section III deals with the amino acids and shows how the metabolism of amino acids also uses and yields energy. Section IV describes the structures and functions of the nucleic acids, covering the representation DNAr RNAr proteins. This section also describes the principle of recombinant DNA technology, a topic with tremendous implications for biomedical science and all of biology. Section V discusses hormones and their key roles in intercellular communication and metabolic regulation. To affect cells, hormones must first interact with the plasma membranes of cells; thus membrane structure and function are addressed initially in this section. Section VI consists of fourteen special topics: water- and lipid-soluble vitamins, nutrition, digestion and absorption, glycoproteins, the extracellular matrix, muscle, plasma proteins (and immunoglobins and blood coagulation), red and white blood cells, metabolism of xenobiotics, cancer and growth factors, the biochemical and genetic bases of diseases, various neuropsychiatric disorders, and ten biochemical case studies. The Appendix contains a list of the major biochemical laboratory tests and their reference ranges used in clinical medicine.

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Product Details

ISBN-13:
9780838536841
Publisher:
McGraw-Hill Companies, The
Publication date:
08/28/1999
Series:
Lange Series
Edition description:
Older Edition
Pages:
928
Product dimensions:
7.18(w) x 9.98(h) x 1.34(d)

Meet the Author

Robert K. Murray, MD, PhD (University of Toronto, Ontario, Canada)

Daryl K. Granner, MD (Vanderbilt University, Nashville, Tennessee)

Peter A. Mayes, PhD, DSc (University of London, London, England)

Victor W. Rodwell, PhD (Purdue University, West Lafayette, Indiana

Table of Contents

Preface
1Biochemistry and Medicine1
2Biomolecules and Biochemical Methods6
3Water and pH15
Sect. IStructures & Functions of Proteins & Enzymes27
4Amino Acids27
5Peptides37
6Proteins: Structure and Function48
7Proteins: Myoglobin and Hemoglobin63
8Enzymes: General Properties74
9Enzymes: Kinetics86
10Enzymes: Mechanisms of Action103
11Enzymes: Regulation of Activities110
Sect. IIBioenergetics & the Metabolism of Carbohydrates & Lipids123
12Bioenergetics: The Role of ATP123
13Biologic Oxidation130
14The Respiratory Chain and Oxidative Phosphorylation137
15Carbohydrates of Physiologic Significance149
16Lipids of Physiologic Significance160
17Overview of Intermediary Metabolism172
18The Citric Acid Cycle: The Catabolism of Acetyl-CoA182
19Glycolysis and the Oxidation of Pyruvate190
20Metabolism of Glycogen199
21Gluconeogenesis and Control of the Blood Glucose208
22The Pentose Phosphate Pathway and Other Pathways of Hexose Metabolism219
23Biosynthesis of Fatty Acids230
24Oxidation of Fatty Acids: Ketogenesis238
25Metabolism of Unsaturated Fatty Acids and Eicosanoids250
26Metabolism of Acylglycerols and Sphingolipids259
27Lipid Transport and Storage268
28Cholesterol Synthesis, Transport, and Excretion285
29Integration of Metabolism and the Provision of Tissue Fuels298
Sect. IIIMetabolism of Proteins & Amino Acids307
30Biosynthesis of the Nutritionally Nonessential Amino Acids307
31Catabolism of Proteins and of Amino Acid Nitrogen313
32Catabolism of the Carbon Skeletons of Amino Acids323
33Conversion of Amino Acids to Specialized Products347
34Porphyrins and Bile Pigments359
Sect. IVStructure, Function, & Replication of Informational Macromolecules375
35Nucleotides375
36Metabolism of Purine and Pyrimidine Nucleotides386
37Nucleic Acid Structure and Function402
38DNA Organization, Replication, and Repair412
39RNA Synthesis, Processing, and Modification435
40Protein Synthesis and the Genetic Code452
41Regulation of Gene Expression468
42Recombinant DNA Technology488
Sect. VBiochemistry of Extracellular & Intracellular Communication505
43Membranes: Structure, Assembly, and Function505
44Hormone Action534
45Pituitary and Hypothalamic Hormones550
46Thyroid Hormones561
47Hormones That Regulate Calcium Metabolism567
48Hormones of the Adrenal Cortex575
49Hormones of the Adrenal Medulla588
50Hormones of the Gonads594
51Hormones of the Pancreas and Gastrointestinal Tract610
Sect. VISpecial Topics627
52Structure and Function of the Water-Soluble Vitamins627
53Structure and Function of the Lipid-Soluble Vitamins642
54Nutrition653
55Digestion and Absorption662
56Glycoproteins675
57The Extracellular Matrix695
58Muscle and the Cytoskeleton715
59Plasma Proteins, Immunoglobulins, and Blood Coagulation737
60Red and White Blood Cells763
61Metabolism of Xenobiotics780
62Cancer, Cancer Genes, and Growth Factors787
63Biochemical and Genetic Bases of Disease812
64The Biochemical Basis of Some Neuropsychiatric Disorders829
65Biochemical Case Histories850
Appendix867
Abbreviations873
Index877

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