Harper's Biochemistry 25th Edition (Lange Series) / Edition 25

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The overall objective of this silver edition of Harper's Biochemistry is to provide concise yet authoritative coverage of the principles of biochemistry and molecular biology. The text offers numerous examples of how knowledge of biochemistry is essential for understanding the maintenance of health and the causes and rational treatment of many diseases.


  • Covers the fundamentals of biochemistry in a relevant interesting manner
  • Contains information on prevalent medical conditions, including hypercholesterolemia, obesity, osteoporosis, and diabetes mellitus
  • Covers new developments in metabolism and genetics, including the Human Genome Project and the genetic basis of hemochromatosis
  • Presents hundreds of colorful images to help students visualize new information

The book is divided into three introductory chapters followed by six main sections. Section I deals with proteins and enzymes, the workhorses of the body. Because enzymes catalyze most reactions in the human body, it is vital to understand the properties of enzymes before moving on to other topics. Section II explains how various cellular reactions either utilize or produce energy and traces the pathways by which carbohydrates and lipids are synthesized and degraded. The many functions of these two classes of molecules are also described. Section III deals with the amino acids and shows how the metabolism of amino acids also uses and yields energy. Section IV describes the structures and functions of the nucleic acids, covering the representation DNAr RNAr proteins. This section also describes the principle of recombinant DNA technology, a topic with tremendous implications for biomedical science and all of biology. Section V discusses hormones and their key roles in intercellular communication and metabolic regulation. To affect cells, hormones must first interact with the plasma membranes of cells; thus membrane structure and function are addressed initially in this section. Section VI consists of fourteen special topics: water- and lipid-soluble vitamins, nutrition, digestion and absorption, glycoproteins, the extracellular matrix, muscle, plasma proteins (and immunoglobins and blood coagulation), red and white blood cells, metabolism of xenobiotics, cancer and growth factors, the biochemical and genetic bases of diseases, various neuropsychiatric disorders, and ten biochemical case studies. The Appendix contains a list of the major biochemical laboratory tests and their reference ranges used in clinical medicine.

This book provides the biochemistry background needed to succeed in medical school. It contains the latest case studies, discussions of biochemical diseases and clinical information. Concise but comprehensive, it is the perfect textbook or USMLE review.

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Product Details

  • ISBN-13: 9780838536841
  • Publisher: McGraw-Hill Companies, The
  • Publication date: 8/28/1999
  • Series: Lange Series
  • Edition description: Older Edition
  • Edition number: 25
  • Pages: 928
  • Product dimensions: 7.18 (w) x 9.98 (h) x 1.34 (d)

Meet the Author

Robert K. Murray, MD, PhD (University of Toronto, Ontario, Canada)

Daryl K. Granner, MD (Vanderbilt University, Nashville, Tennessee)

Peter A. Mayes, PhD, DSc (University of London, London, England)

Victor W. Rodwell, PhD (Purdue University, West Lafayette, Indiana

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Table of Contents

1 Biochemistry and Medicine 1
2 Biomolecules and Biochemical Methods 6
3 Water and pH 15
Sect. I Structures & Functions of Proteins & Enzymes 27
4 Amino Acids 27
5 Peptides 37
6 Proteins: Structure and Function 48
7 Proteins: Myoglobin and Hemoglobin 63
8 Enzymes: General Properties 74
9 Enzymes: Kinetics 86
10 Enzymes: Mechanisms of Action 103
11 Enzymes: Regulation of Activities 110
Sect. II Bioenergetics & the Metabolism of Carbohydrates & Lipids 123
12 Bioenergetics: The Role of ATP 123
13 Biologic Oxidation 130
14 The Respiratory Chain and Oxidative Phosphorylation 137
15 Carbohydrates of Physiologic Significance 149
16 Lipids of Physiologic Significance 160
17 Overview of Intermediary Metabolism 172
18 The Citric Acid Cycle: The Catabolism of Acetyl-CoA 182
19 Glycolysis and the Oxidation of Pyruvate 190
20 Metabolism of Glycogen 199
21 Gluconeogenesis and Control of the Blood Glucose 208
22 The Pentose Phosphate Pathway and Other Pathways of Hexose Metabolism 219
23 Biosynthesis of Fatty Acids 230
24 Oxidation of Fatty Acids: Ketogenesis 238
25 Metabolism of Unsaturated Fatty Acids and Eicosanoids 250
26 Metabolism of Acylglycerols and Sphingolipids 259
27 Lipid Transport and Storage 268
28 Cholesterol Synthesis, Transport, and Excretion 285
29 Integration of Metabolism and the Provision of Tissue Fuels 298
Sect. III Metabolism of Proteins & Amino Acids 307
30 Biosynthesis of the Nutritionally Nonessential Amino Acids 307
31 Catabolism of Proteins and of Amino Acid Nitrogen 313
32 Catabolism of the Carbon Skeletons of Amino Acids 323
33 Conversion of Amino Acids to Specialized Products 347
34 Porphyrins and Bile Pigments 359
Sect. IV Structure, Function, & Replication of Informational Macromolecules 375
35 Nucleotides 375
36 Metabolism of Purine and Pyrimidine Nucleotides 386
37 Nucleic Acid Structure and Function 402
38 DNA Organization, Replication, and Repair 412
39 RNA Synthesis, Processing, and Modification 435
40 Protein Synthesis and the Genetic Code 452
41 Regulation of Gene Expression 468
42 Recombinant DNA Technology 488
Sect. V Biochemistry of Extracellular & Intracellular Communication 505
43 Membranes: Structure, Assembly, and Function 505
44 Hormone Action 534
45 Pituitary and Hypothalamic Hormones 550
46 Thyroid Hormones 561
47 Hormones That Regulate Calcium Metabolism 567
48 Hormones of the Adrenal Cortex 575
49 Hormones of the Adrenal Medulla 588
50 Hormones of the Gonads 594
51 Hormones of the Pancreas and Gastrointestinal Tract 610
Sect. VI Special Topics 627
52 Structure and Function of the Water-Soluble Vitamins 627
53 Structure and Function of the Lipid-Soluble Vitamins 642
54 Nutrition 653
55 Digestion and Absorption 662
56 Glycoproteins 675
57 The Extracellular Matrix 695
58 Muscle and the Cytoskeleton 715
59 Plasma Proteins, Immunoglobulins, and Blood Coagulation 737
60 Red and White Blood Cells 763
61 Metabolism of Xenobiotics 780
62 Cancer, Cancer Genes, and Growth Factors 787
63 Biochemical and Genetic Bases of Disease 812
64 The Biochemical Basis of Some Neuropsychiatric Disorders 829
65 Biochemical Case Histories 850
Appendix 867
Abbreviations 873
Index 877
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