Harper's Illustrated Biochemistry, 28th Edition / Edition 28

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2009 Trade paperback 28th ed. New. Trade paperback (US). Sewn binding. 693 p. Contains: Illustrations. Harper's Illustrated Biochemistry. Audience: General/trade. *****PLEASE ... NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Overview

The biochemistry text that every medical student must own—now in full color!

A Doody's Core Title ESSENTIAL PURCHASE for 2011!

Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease.

The Twenty-Eighth Edition has undergone sweeping changes — including a conversion to full-color artwork and the substantial revision and updating of every chapter — all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject.

Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic.

NEW to this edition:

  • Full-color presentation, including 600+ illustrations
  • Every chapter opens with a Summary of the Biomedical Importance and concludes with a Summary reviewing the topics covered
  • Two all-new chapters: "Free Radicals and Antioxidant Nutrients" and "Biochemical Case Histories" which offers an extensive presentation of 16 clinical conditions
  • A new appendix containing basic clinical laboratory results and an updated one with a list of important websites and online journals
  • NEW or updated coverage of important topics including the Human Genome Project and computer-aided drug delivery
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Editorial Reviews

From The Critics
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This book provides an overview of biochemistry with an emphasis on topics thought to be relevant to medical students. The last edition was published in 2000.
Purpose: The goal of this long-running series is to provide detailed coverage of all aspects of biochemistry as applied to medicine. For many students, this is a convenient (and relatively inexpensive) review book. Overall, the coverage is reasonable and users seeking specific information are likely to find it. Integration with clinical problems is lacking as is an organization that would make better sense given the stated objectives.
Audience: This book is intended primarily for medical students either as an auxiliary text or as a convenient review source when preparing for the USMLE part I examination..
Features: This 26th edition provides a thorough presentation of all aspects of biochemistry relevant to medical students. Changes from the 25th edition include some condensation of material, a limited amount of revision and new material, primarily in the area of recombinant DNA (including a short chapter on the human genome). The terse style allows for considerable detail, especially in metabolic pathway presentation. The coverage of the endocrine system and the role of hormones is effective. Initial chapters discuss general structural principles of proteins, carbohydrates and lipids, and the function and general mechanism of enzymes. All aspects of intermediary metabolism are discussed as well as material dealing with membranes, specialized tissues (muscle, formed elements ofblood etc.), vitamins and general features of nutrition. The teaching of biochemistry in medical school has evolved, however, and the overall organization of this book would not serve effectively for many students. Thus, the section on metabolism gives little sense of integration and control. Regrettably, there are no quick fixes to deal with the increasing amount of material in this field: the student is advised to learn principles rather than memorize reactions. Application in context will be easier under such circumstances. Those needing a compilation that is thorough and concise will find this book of value.
Assessment: This book is somewhat outdated. The coverage is generally thorough, but the multiauthor format leads to revision of individual sections and less attention to how the material should be presented for pedagogic efficacy. There are many attempts to address the information problem and most students welcome study aids in this complex field. Although the presentation is somewhat dated, some students will find merit here.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780071625913
  • Publisher: McGraw-Hill Medical Publishing Division
  • Publication date: 6/2/2009
  • Series: LANGE Basic Science Series
  • Edition description: Older Edition
  • Edition number: 28
  • Pages: 704
  • Product dimensions: 8.50 (w) x 10.90 (h) x 1.10 (d)

Meet the Author

Robert K. Murray, MD, PhD,

Professor (Emeritus) of Biochemistry,

University of Toronto

David A. Bender, PhD,

Sub-Dean, University College Medical School,

Senior Lecturer in Biochemistry,

Department of Structural and Molecular Biology and

Division of Medical Education,

University College London

Kathleen M. Botham, PhD, DSc,

Professor of Biochemistry, Royal Veterinary

College, University of London

Peter J. Kennelly, PhD,

Professor and Head, Department of Biochemistry,

Virginia Polytechnic Institute and State University,

Blacksburg, Virginia

Victor W. Rodwell, PhD,

Emeritus Professor of Biochemistry, Purdue University, West Lafayette,

Indiana

P. Anthony Weil, PhD,

Professor of Molecular Physiology and Biophysics,

Vanderbilt University School of Medicine,

Nashville, Tennessee

Co-Authors:

Daryl K. Granner, MD,

Emeritus Professor of Molecular Physiology and Biophysics

and Medicine,

Vanderbilt University, Nashville, Tennessee

Peter L. Gross MD, MSc, FRCP(C),

Associate Professor, Department of Medicine,

McMaster University

Frederick W. Keeley, PhD,

Associate Director and Senior Scientist, Research Institute,

Hospital for Sick Children, Toronto, and Professor,

Department of Biochemistry, University of Toronto

Peter A. Mayes, PhD, DSc,

Emeritus Professor of Veterinary Biochemistry, Royal Veterinary College, University of London

Margaret L. Rand, PhD,

Associate Senior Scientist, Hospital for Sick Children, Toronto,

and Professor, Departments of Laboratory Medicine and Pathobiology

and Department of Biochemistry, University of Toronto

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Table of Contents

Authors
Preface
1 Biochemistry & Medicine 1
2 Water & pH 5
3 Amino Acids & Peptides 14
4 Proteins: Determination of Primary Structure 21
5 Proteins: Higher Orders of Structure 30
6 Proteins: Myoglobin & Hemoglobin 40
7 Enzymes: Mechanism of Action 49
8 Enzymes: Kinetics 60
9 Enzymes: Regulation of Activities 72
10 Bioenergetics: The Role of ATP 80
11 Biologic Oxidation 86
12 The Respiratory Chain & Oxidative Phosphorylation 92
13 Carbohydrates of Physiologic Significance 102
14 Lipids of Physiologic Significance 111
15 Overview of Metabolism 122
16 The Citric Acid Cycle: The Catabolism of Acetyl-CoA 130
17 Glycolysis & the Oxidation of Pyruvate 136
18 Metabolism of Glycogen 145
19 Gluconeogenesis & Control of the Blood Glucose 153
20 The Pentose Phosphate Pathway & Other Pathways of Hexose Metabolism 163
21 Biosynthesis of Fatty Acids 173
22 Oxidation of Fatty Acids: Ketogenesis 180
23 Metabolism of Unsaturated Fatty Acids & Eicosanoids 190
24 Metabolism of Acylglycerols & Sphingolipids 197
25 Lipid Transport & Storage 205
26 Cholesterol Synthesis, Transport, & Excretion 219
27 Integration of Metabolism - the Provision of Metabolic Fuels 231
28 Biosynthesis of the Nutritionally Nonessential Amino Acids 237
29 Catabolism of Proteins & of Amino Acid Nitrogen 242
30 Catabolism of the Carbon Skeletons of Amino Acids 249
31 Conversion of Amino Acids to Specialized Products 264
32 Porphyrins & Bile Pigments 270
33 Nucleotides 286
34 Metabolism of Purine & Pyrimidine Nucleotides 293
35 Nucleic Acid Structure & Function 303
36 DNA Organization, Replication, & Repair 314
37 RNA Synthesis, Processing, & Modification 341
38 Protein Synthesis & the Genetic Code 358
39 Regulation of Gene Expression 374
40 Molecular Genetics, Recombinant DNA, & Genomic Technology 396
41 Membranes: Structure & Function 415
42 The Diversity of the Endocrine System 434
43 Hormone Action & Signal Transduction 456
44 Nutrition, Digestion, & Absorption 474
45 Vitamins & Minerals 481
46 Intracellular Traffic & Sorting of Proteins 498
47 Glycoproteins 514
48 The Extracellular Matrix 535
49 Muscle & the Cytoskeleton 556
50 Plasma Proteins & Immunoglobulins 580
51 Hemostasis & Thrombosis 598
52 Red & White Blood Cells 609
53 Metabolism of Xenobiotics 626
54 The Human Genome Project 633
Appendix 639
Index 643
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