Harper's Illustrated Biochemistry, 28th Edition [NOOK Book]

Overview

The biochemistry text that every medical student must own--now in full color!



Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease.



The Twenty-Eighth Edition has undergone sweeping changes -- ...

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Harper's Illustrated Biochemistry, 28th Edition

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Overview

The biochemistry text that every medical student must own--now in full color!



Comprehensive, concise, and up-to-date, Harper's is unrivaled in its ability to clarify the link between biochemistry and the molecular basis of health and disease.



The Twenty-Eighth Edition has undergone sweeping changes -- including a conversion to full-color artwork and the substantial revision and updating of every chapter -- all to reflect the latest advances in knowledge and technology and to make the text as up-to-date and clinically relevant as possible. Combining outstanding full-color illustrations with integrated coverage of biochemical diseases and clinical information, Harper's Illustrated Biochemistry offers an organization and clarity not found in any other text on the subject.



Striking just the right balance between detail and brevity, Harpers Illustrated Biochemistry is essential for USMLE review and is the single best reference for learning the clinical relevance of a biochemistry topic.



NEW to this edition:



  • Full-color presentation, including 600+ illustrations

  • Every chapter opens with a Summary of the Biomedical Importance and concludes with a Summary reviewing the topics covered

  • Two all-new chapters: "Free Radicals and Antioxidant Nutrients" and "Biochemical Case Histories" which offers an extensive presentation of 16 clinical conditions

  • A new appendix containing basic clinical laboratory results and an updated one with a list of important websites and online journals

  • NEW or updated coverage of important topics including the Human Genome Project and computer-aided drug delivery

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Editorial Reviews

From The Critics
Reviewer: Eugene A Davidson, PhD (Georgetown University School of Medicine)
Description: This book provides an overview of biochemistry with an emphasis on topics thought to be relevant to medical students. The last edition was published in 2000.
Purpose: The goal of this long-running series is to provide detailed coverage of all aspects of biochemistry as applied to medicine. For many students, this is a convenient (and relatively inexpensive) review book. Overall, the coverage is reasonable and users seeking specific information are likely to find it. Integration with clinical problems is lacking as is an organization that would make better sense given the stated objectives.
Audience: This book is intended primarily for medical students either as an auxiliary text or as a convenient review source when preparing for the USMLE part I examination..
Features: This 26th edition provides a thorough presentation of all aspects of biochemistry relevant to medical students. Changes from the 25th edition include some condensation of material, a limited amount of revision and new material, primarily in the area of recombinant DNA (including a short chapter on the human genome). The terse style allows for considerable detail, especially in metabolic pathway presentation. The coverage of the endocrine system and the role of hormones is effective. Initial chapters discuss general structural principles of proteins, carbohydrates and lipids, and the function and general mechanism of enzymes. All aspects of intermediary metabolism are discussed as well as material dealing with membranes, specialized tissues (muscle, formed elements ofblood etc.), vitamins and general features of nutrition. The teaching of biochemistry in medical school has evolved, however, and the overall organization of this book would not serve effectively for many students. Thus, the section on metabolism gives little sense of integration and control. Regrettably, there are no quick fixes to deal with the increasing amount of material in this field: the student is advised to learn principles rather than memorize reactions. Application in context will be easier under such circumstances. Those needing a compilation that is thorough and concise will find this book of value.
Assessment: This book is somewhat outdated. The coverage is generally thorough, but the multiauthor format leads to revision of individual sections and less attention to how the material should be presented for pedagogic efficacy. There are many attempts to address the information problem and most students welcome study aids in this complex field. Although the presentation is somewhat dated, some students will find merit here.

2 Stars from Doody
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Product Details

  • ISBN-13: 9780071701976
  • Publisher: McGraw-Hill Education
  • Publication date: 6/12/2009
  • Series: LANGE Basic Science
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 28
  • Pages: 704
  • File size: 36 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Robert K. Murray, MD, PhD,

Professor (Emeritus) of Biochemistry,

University of Toronto




David A. Bender, PhD,

Sub-Dean, University College Medical School,

Senior Lecturer in Biochemistry,

Department of Structural and Molecular Biology and

Division of Medical Education,

University College London




Kathleen M. Botham, PhD, DSc,

Professor of Biochemistry, Royal Veterinary

College, University of London




Peter J. Kennelly, PhD,

Professor and Head, Department of Biochemistry,

Virginia Polytechnic Institute and State University,

Blacksburg, Virginia




Victor W. Rodwell, PhD,

Emeritus Professor of Biochemistry, Purdue University, West Lafayette,

Indiana




P. Anthony Weil, PhD,

Professor of Molecular Physiology and Biophysics,

Vanderbilt University School of Medicine,

Nashville, Tennessee





Co-Authors:




Daryl K. Granner, MD,

Emeritus Professor of Molecular Physiology and Biophysics

and Medicine,

Vanderbilt University, Nashville, Tennessee


Peter L. Gross MD, MSc, FRCP(C),

Associate Professor, Department of Medicine,

McMaster University




Frederick W. Keeley, PhD,

Associate Director and Senior Scientist, Research Institute,

Hospital for Sick Children, Toronto, and Professor,

Department of Biochemistry, University of Toronto




Peter A. Mayes, PhD, DSc,

Emeritus Professor of Veterinary Biochemistry, Royal Veterinary College, University of London




Margaret L. Rand, PhD,

Associate Senior Scientist, Hospital for Sick Children, Toronto,

and Professor, Departments of Laboratory Medicine and Pathobiology

and Department of Biochemistry, University of Toronto

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Table of Contents

1. Biochemistry and Medicine2. Water & PH3. Amino Acids and Peptides4. Proteins: Determination of Primary Structure5. Proteins: Higher Orders of Structure6. Proteins: Myoglobin and Hemoglobin7. Enzymes: Mechanisms of Action8. Enzymes: Kinetics9. Enzymes: Regulation of Activities10. Bioenergetics: The Role of ATP11. Biologic Oxidation12. The Respiratory Chain & Oxidative Phosphorylation13. Carbohydrates of Physiologic Significance14. lipids of Physiologic Significance15. Overview of Metabolism16. The Citric acid Cycle: The Catabolism of Acetyl-CoA17. Glycolysis and Oxidation of Pyruvate18. Metabolism of Glycogen19. Gluconeogenesis and Control of the Blood Glucose20. The Pentose Phosphate Pathway & other Pathways of Hexose Metabolism21. Biosynthesis of Fatty Acids22. Oxidation of Fatty Acids: Ketogenesis23. Metabolism of Unsaturated Fatty Acids & Eicosanoids24. Metabolism of Acyglycerols and Sphingolipids25. Lipid Transport And Storage26. Cholesterol Synthesis, Transport and Excretion27. Integration of Metabolism- the Provision of Metabolic Fuels28. Biosynthesis of Nutritionally Nonessential Amino Acids29. Catabolism of Proteins & of Amino Acid Nitrogen30. Catabolism of the Carbon Skeletons of Amino Acids31. Conversion of Amino Acids32. Porphyrins & Bile Pigments33. Nucleotides34. Metabolism of Purine & Pyrimidine Nucleotides35. Nucleic Acid Structure and Function36. DNA Organization, Replication and Repair37. RNA Synthesis, Processing and Modifications38. Protein Synthesis and Genetic Code39. Regulation of Gene Expression40. Molecular Genetics, Recombinant DNE and Genomic Technology41. Membranes: Structure and Function42. The Diversity of Endocrine System43. Hormone Action and Signal Transduction44. Nutrition, Digestion and Absorption45. Vitamins and Minerals46. Intracellular Traffic and Sorting of Proteins47. Glycoprotein48. The Extracellular Matrix49. Muscle and the Cytoskeleton50. Plasma Proteins and Immunoglobulins51. Homeostasis and Thrombosis52. The Red and White Blood Cells53. Metabolism of Xenobiotics54. The Human Genome Project
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