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Doody's Review ServiceReviewer: Richa Gupta, MD (University of Kentucky College of Medicine)
Description: This book on the rheumatologic diseases is divided into two broad sections - immune-mediated disorders and disorders of the joints. Every chapter details the basic science, pathophysiology, and clinical description of the disease. The previous edition was published in 2006.
Purpose: Derived from the rheumatology chapters in Harrison's Principles of Internal Medicine, 17th edition, the book moves from basic science research and an understanding of disease processes and pathophysiology to the bedside to benefit overall patient care. Understanding the disease process at a cellular and molecular level makes clinicians better physicians overall, particularly when there have been such significant advances in the understanding of the basic science of several rheumatologic diseases over the past few years.
Audience: The book is written for medical students and rheumatologists and immunologists in training, as well as for those in clinical practice.
Features: The book covers innate and adaptive immunity, cytokines, autoimmunity, mechanisms, major histocompatibility complex, lupus, RA, acute rheumatic fever, systemic sclerosis, Sjogrens syndrome, spondyloarthropathies, vasculitis syndromes, Behcets, relapsing polychondritis, sarcoidosis, polymyositis and dermatomyositis, amyloidosis, familial Mediterranean fever, osteoarthritis, crystalline arthritis, infectious arthritis, and fibromyalgia. It includes a detailed laboratory values section, and questions and answers for review and self assessment. The best parts of the book are the systematic approach to the basics of immunity and the pictorial, colorful cartoon diagrams illustrating mechanisms of autoimmunity, MHC, and various disease pathologies and mechanisms. The detailed laboratory value section is useful, especially because it brings all this information together in one book.
Assessment: This is a high quality book, written in simple and easy to understand language, with very good illustrations of the basic science and immunology of rheumatologic diseases, expanding the knowledge and understanding of the immune-mediated pathophysiology of rheumatologic diseases. It brings bench research to the bedside, improving the overall care of patients. The updated chapters with the latest evidence justify replacing the previous edition.