Haschek and Rousseaux's Handbook of Toxicologic Pathology


Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics,...

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Haschek and Rousseaux's Handbook of Toxicologic Pathology

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Haschek and Rousseaux's Handbook of Toxicologic Pathology is a key reference on the integration of structure and functional changes in tissues associated with the response to pharmaceuticals, chemicals and biologics. The 3e has been expanded by a full volume, and covers aspects of safety assessment not discussed in the 2e. Completely revised with many new chapters, it remains the most authoritative reference on toxicologic pathology for scientists and researchers studying and making decisions on drugs, biologics, medical devices and other chemicals, including agrochemicals and environmental contaminants. New topics include safety assessment, the drug life cycle, risk assessment, communication and management, carcinogenicity assessment, pharmacology and pharmacokinetics, biomarkers in toxicologic pathology, quality assurance, peer review, agrochemicals, nanotechnology, food and toxicologic pathology, the environment and toxicologic pathology and more.

  • Provides new chapters and in-depth discussion of timely topics in the area of toxicologic pathology and broadens the scope of the audience to include toxicologists and pathologists working in a variety of settings
  • Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology
  • Features hundreds of full color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations

Audience: Researchers in the area of toxicology and pathology, veterinary scientists, veterinary diagnostic and medical forensic laboratories, and pharmaceutical and chemical companies.

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Editorial Reviews

From the Publisher
"This publication should be on the bookshelf of clinical toxicologists, environmental professionals and laboratory investigators..."
—Veterinary and Human Toxicology (October 2002)
"...very readable, well-referenced, and current... an excellent book for research training."
Veterinary Pathology
"Occasionally, a book becomes available that sets a new standard for a subspecialty, and such is the case for the third Edition...This substantially sized...and exceptionally compiled and useful book gathers extensive knowledge from the field of toxicologic pathology as well as tangential and integrative areas...the third edition of this handbook lends itself to being a reference book that reads like an accessible and helpful textbook." (Vol 51(1), 2014)
International Journal of Toxicology
"The 3 volumes are well organized, and the editors have endeavored to provide clearer and more complete content description for chapter titles that will be easier for nonpathologist to recognize. This handbook belongs on the physical- or e-shelf of practitioners of toxicologic pathology and toxicology and needs to be in the communal library of a broad range of individuals in life sciences who interact with toxicologic pathologists." (December 2, 2013)
Paul Baldrick
...gives an excellent overview of the numerous processes associated with toxicologic pathology as used in risk assessment. It stands alone as a classic textbook in toxicology, or would be an excellent supplement to other such books. ...Its readability will allow acceptance to all scientists ranging from undergraduate to experienced industry/regulatory professional.
From The Critics
Volume one in this expanded second edition addresses general pathology and is divided into three parts: basics of toxicologic pathology, the practice of toxicologic pathology, and selected topics, such as principles of risk communication, biotechnology and its products, nutritional toxicological pathology, and heavy metals. Volume two covers organ-specific toxicologic pathology. A number of new chapters address new technological developments such as laser capture dissection and new imaging modalities. Chapters related to the practice of toxicologic pathology discuss topics such as how to avoid pitfalls by paying attention to study design and taking advantage of peer review; issues in laboratory animal science, including regulatory issues, animal health considerations, and the role of diet in toxicological studies; new animal models, including the many strains of genetically engineered rodents available; and the use and misuse of statistics in the design and interpretation of studies. Two of the editors, Wanda Haschek and Matthew Wallig are affiliated with the College of Veterinary Medicine at the U. of Illinois, Urbana-Champaign; Colin Rousseaux is from the University of Ottowa's Department of Cellular and Molecular Medicine. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: David M Pinson, DVM, PhD, ACVP, ACLAM (University of Kansas Medical Center)
Description: This handbook is organized into two broad areas: general toxicologic pathology and organ specific toxicologic pathology. The first edition was published in 1991.
Purpose: The importance of the discipline of toxicologic pathology is far reaching in the application of regulations to products and product liability. The subject has implications for both human and animal health, particularly relative to the safety evaluation of drugs, agrochemicals, and other materials and equipment used in medicine, agriculture, and industry. The book is intended to provide an educational resource in the interface between the disciplines of applied toxicology and toxicologic pathology and this objective is accomplished well.
Audience: Although the book has clear importance for the student of toxicology, this is also a useful reference for teaching faculty, particularly relative to general pathology mechanisms and some foundations in good research study design. The text contains some useful reviews of basic pathology mechanisms, but it is clearly not targeted to clinical education. Many of the contributors are highly recognized for their expertise.
Features: This two-volume set contains 44 chapters that cover basic pathologic mechanisms (such as carcinogenesis, apoptosis, oncotic necrosis, etc.), study design, statistics, report writing, lesion classification, clinical pathology and systems pathology. The major strengths of the book are the summaries of mechanisms, which can then be explored in more depth in primary journal literature, and the scope of coverage.
Assessment: The book is very readable, well-referenced, and current. The quality of the work represents the rigors under which most toxicologic pathologists work. It provides a unique summary of most of the disciplines that any practicing biomedical research scientist would find useful. This is an excellent book for research training.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780124157590
  • Publisher: Elsevier Science
  • Publication date: 7/1/2013
  • Edition number: 3
  • Pages: 3054
  • Product dimensions: 8.70 (w) x 11.00 (h) x 1.40 (d)

Table of Contents

Volume 1: Practice of Toxicologic Pathology includes the principles and methods of toxicologic pathology and their application to practice.

Volume 2: Safety Assessment and Other Issues in Toxicologic Pathology focuses on toxicologic pathology from a drug discovery and regulatory standpoint, including coverage of data interpretation and expanded content on environmental and food toxicology.

Volume 3: Systems Toxicologic Pathology organizes toxicologic pathology by biological systems and addresses the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation.

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