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In a climate where many unsubstantiated claims are made, it is essential to have access to the best evidence-based knowledge on how to extend healthy life expectancy. Researchers, healthcare practitioners, and policy makers come together annually at the International Research Center for Healthy Ageing and Longevity to discuss, debate, and exchange ideas, and the proceedings of the most recent conference is contained in the chapters of this volume.
Now, more than ever, a critical need exists for the development of appropriate policies so that aging is seen as a resource and not as an isolating and segregating experience. Solid research elucidating the processes of aging must be translated into strategies for clinical practice in order to respond to the needs of an aging population.
The full spectrum of proven and potential aging interventions including pharmaceutical, nutritional, clinical, educational, policy, complementary, preventive, and restorative means were explored at this international meeting. The topics covered in this volume include the following:
(1) Nutritional interventions in aging and age-associated disease, both diet and supplements;
(2) dementia in an aging population;
(3) the new caring — financial and asset management and substitute decision-making by and for older people;
(4) how we improve the quality of research into healthy aging;
(5) promoting balance and preventing falls in an aging population;
(6) population aging in developing countries;
(7) promoting health and well-being of the older community;
(8) hormone and metabolic interventions in aging;
(9) community attitudes and approaches towards human life extension;
(10) respecting the elders in our care;
(11) the biology of healthy aging and longevity;
(12) basic science and mechanisms of aging and longevity;
(13) sustaining optimal aging — inner strength and mutual support;
(14) wellbeing, retirement planning and expectations of the baby-boomer generation;
(15) natural and complementary approaches to age-associated disorders;
(16) psychosocial predictors of healthy aging and longevity — lessons from longitudinal studies;
(17) healthy longevity — lessons learned from the world's longest-lived people;
(18) the aging brain;
(19) baby-boomer work force participation;
(20) quality of care and quality of life for the elderly;
(21) frontiers of knowledge in biogerontology;
(22) behavioural and social interventions for healthy aging and longevity.
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Preface: Noah J. Weller, John D. Weller, and Christian J. Weller.
Part I: Biogerontology:.
1. The Science of Healthy Aging: Genes, Milieu and Chance: Suresh I. S. Rattan.
2. Pursuing the Longevity Dividend: Scientific Goals for an Aging World: S. Jay Olshansky, Daniel Perry, Richard A. Miller, and Robert N. Butler.
3. Senescence Viewed Through the Lens of Comparative Biology: Bruce A. Carnes.
4. Cytomegalovirus Infection: A Driving Force in Human T cell Immunosenescence: Sven Koch, Anis Larbi, Dennis Özcelik, Rafael Solana, Cécile Gouttefangeas, Sebastian Attig, Anders Wikby, Jan Strindhall, Claudio Franceschi, Graham Pawelec.
5. Transcriptional Regulation of Telomerase Activity: Roles of the Ets Transcription Factor Family: Julie Dwyer, He Li, Dakang Xu, and Jun-Ping Liu.
6. Potential Roles for Estrogen Regulation of Telomerase Activity in Aging: Sharyn Bayne, Margaret E. E. Jones, He Li and Jun-Ping Liu.
7. Mechanisms of Action of TGFb in Cancer: Evidence for Smad3 as a Repressor of the hTERT Gene: He Li and Jun-Ping Liu.
8. Evidence That Autophagy Is Involved in Aging and Is an Essential Part in the Anti-aging Mechanism of Caloric Restriction: Ettore Bergamini, Gabriella Cavallini, Alessio Donati and Zina Gori.
9. Age-related Changes in the Liver Sinusoidal Endothelium Are a Mechanism for Dyslipidemia: David G. Le Couteur, Victoria C. Cogger, Robert S. McCuskey, Rafael de Cabo, Bård Smedsrød, Karen K Sorensen, Alessandra Warren, Robin Fraser.
10. Effects of Old Age on Hepatocyte Oxygenation: Rajkumar Cheluvappa, Sarah N Hilmer, Sun Young Kwun, Victoria C Cogger, David G Le Couteur.
11. Comparative Analysis of Mitochondrial Genotype and Aging: J. William O. Ballard, Subhash D. Katewa, Richard G. Melvin, and Grace Chan.
Part II: Clinical Perspective:.
12. Fit and Well at 80: Defying the Stereotypes of Age and Illness: Julie Byles.
13. Delaying Dementia and Nursing Home Placement: The Dubbo Study of Elderly Australians over 14 Years: John McCallum, Leon A. Simons, Judith Simons, and Yechiel Friedlander.
14. Patients with Dementia and Their Carers: Charles Bridges-Webb, Belinda Giles, Catherine Speechly, Yvonne Zurynski, Navaz Hiramanek.
15. Healthy Aging: Can Clinical Trials Deliver?: Erica Bell.
16. Debating the Influence of Self-reports by People Living with Chronic Disease on Healthy Aging and Longevity: Kay Price.
17. Health and Aged Care Enabled by Information Technology: Jeffrey Soar and Youngjoon Seo.
18. Healthy Aging as an Intervention to Minimize Falls Injury among Older People: Nancye May Peel, Helen Patricia Bartlett, Roderick John McClure.
19. Building an Infrastructure to Prevent Falls in Older Californians: The Fall Prevention Center of Excellence: Debra J. Rose, Gretchen E. Alkema, In Hee Choi, Christy M. Nishita, & Jon Pynoos.
20. Age-related Changes in Strength and Somato-sensation during Mid-life Support Rationale for Targeted Preventive Intervention Programs: Nancy L Low Choy, Sandra G Brauer, Jennifer C Nitz.
21. Living Well until You Die: Quality of Care and Quality of Life in Palliative and Dementia Care: Neil Small.
22. Complementary and Alternative Medicine Use by Older Australians: Anthony L Zhang, Charlie CL Xue, Vivian Lin, David F Story.
23. Anti-Aging Medicine and the Cultural Context of Aging in Australia : Beatriz Cardona.
Part III : Socio-cultural Perspective:.
24. Are We Getting Healthier as We Grow Older? Implications for Baby Boomer Labour Force Participation: Deborah J Schofield, Megan E Passey, Arul Earnest, Ian C Gloor, Rupendra Shrestha.
25. Independence, Wellbeing and Social Participation in an Aging Population: Fiona Alpass, Andy Towers, Christine Stephens, Eljon Fitzgerald, Brendan Stevenson, and Judith Davey.
26. Grey Nomads' in Australia: Are They a Good Model for Successful Aging and Health: Paul F. D. Higgs, Frances Quirk.
27. Affordable Rental Housing for Older People in Australia: What Do Older People Want?: Colleen Maria Cartwright.
28. Retirement Planning and Expectation of Australian Babyboomers: Are They Ready?: Wendy Hunter, Wei Wang and Anthony Worsley.
29. Age Identity, Age Perceptions, and Health: Evidence from the English Longitudinal Study of Aging: Panayotes Demakakos, Edlira Gjonca, and James Nazroo.
30. Community Attitudes to the Regulation of Life Extension: Mair Underwood, Helen Bartlett and Wayne Hall.
31. Тhe Еlderly in a Period of Transition: Health, Personality and Social Aspects of Adaptation: Ignat C. Petrov.
32. The Human Mosaic: Cultural Beliefs and Health Professions Training: Rosellen M. Rosich.
33. Lifestyle of the Elderly in Rural and Urban Malaysia: Doris Padmini Selvaratnam and Poo Bee Tin.
34. Healthy Aging for Caregivers: What Are Their Needs?: Tina Wu and Karen Lo.
35. Well for Life, A Way of Life: Wendi A. Kruger, Catherine E. Thompson, Rosemary A. McKenzie, Lucio Naccarella.
36. A Management Control System for the Development, Contracting and Monitoring of Services for Older People: Stephen Jacobs.
37. The New Caring: Financial Asset Management and Older People: Cheryl Tilse, Jill Wilson, Deborah Setterlund, Linda Rosenman.
38. Involving Service Users and their Carers as Equal Partners on a Project Using Electronic Communication: Susan M Ashby, Sian E Maslin-Prothero, Amelia C Rout.
Part IV: Interventions:.
39. Nutritional Interventions in Aging and Age-associated Diseases : George S. Roth, Donald K. Ingram, James A. Joseph.
40. From Beans to Berries and Beyond: Teamwork between Plant Chemicals for Protection of Optimal Human Health: Mary Ann Lila.
41. Dietary Polyunsaturated Fatty Acids and Age-related Membrane Changes in the Heart: Salvatore Pepe.
42. Dietary Influences on Cognitive Function with Aging: From High Fat Diets to Healthful Eating: Matthew D Parrotta, Carol E Greenwood.
43. Combining an Antioxidant Fortified Diet with Behavioral Enrichment Leads to Cognitive Improvement and Reduced Brain Pathology in Aging Canines: Strategies for Healthy Aging: Elizabeth Head.
44. The Effect of Resveratrol on a Cell Model of Human Aging: Maurizio Stefani, M. Andrea Markus, Ruby C. Y. Lin, Mark Pinese, Ian W. Dawes, and Brian J. Morris.
45. Intermittent Dietary Restriction as a Practical Aging Intervention: Sandeep Sharma and Gurcharan Kaur.
46. Life Extension by Calorie Restriction in Humans: Arthur V Everitt, David G Le Couteur.
47. Caloric Restriction, the Traditional Okinawan Diet and Healthy Aging: The Diet of the World's Longest-Lived People and Its Potential Impact on Morbidity and Lifespan: Bradley J. Willcox, D. Craig Willcox, Hidemi Todoriki, Akira Fujiyoshi, Katsuhiko Yano, Qimei He, J. David Curb, Makoto Suzuki.
48. Evidence-based Practice: Limitations and Successful Implementation: Rhonda Maree Nay and Deirdre Marie Ann Fetherstonhaugh