Healthy Aging for Functional Longevity: Molecular and Cellular Interactions in Senescence

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Overview

This volume discusses the latest significant research on the molecular and cellular basis of aging, including the role of oxidative stress in the aging process, and age-related degenerative disorders. It concludes with a section on practical approaches for functional longevity.

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Overview

This volume discusses the latest significant research on the molecular and cellular basis of aging, including the role of oxidative stress in the aging process, and age-related degenerative disorders. It concludes with a section on practical approaches for functional longevity.

Editorial Reviews

Booknews
Papers and the text of poster presentations from the eighth Congress of the International Association of Biomedical Gerontology, held in February 2000 in Kyungju, Korea. Papers from international contributors discuss four main areas of research: basic biomedical changes associated with aging, including topics of protein modification such as oxidation, glycation, and cross-linking; genomic instability, including the problems of DNA repair and the differences in genomic stability between aging and cancer; cellular maintenance and the stress response of senescent cells; and practical approaches for functional longevity, such as nutritional intervention. Indexed by author only. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

Meet the Author

Sang Chul Park is with the Seoul National University of Medicine, South Korea. Eun Seong Hwang is with the University of Seoul, Seoul, South Korea. Hyun-Sook Kim is with the Sookmyung Women's University, Seoul, South Korea. Woong-Yang Park is with the Seoul National University College of Medicine, Seoul, South Korea.

Table of Contents

Preface xi
Part I. Main Theme of Current Aging Research
Aging: Overview 1
Protein Oxidation in Aging and Age-Related Diseases 22
Stress Resistance by Caloric Restriction for Longevity 39
Part II. Biomedical Changes Associated with Aging
Protein Glycation: Creation of Catalytic Sites for Free Radical Generation 48
Implications of Protein Degradation in Aging 54
Transglutaminase-Mediated Crosslinking of Specific Core Histone Subunits and Cellular Senescence 65
Proteome and Proteomics for the Research on Protein Alterations in Aging 71
Attenuation of EGF Signaling in Senescent Cells by Caveolin 79
Part III. Genomic Instability in Aging
BRCA1 Gene Sequence Variation in Centenarians 85
Increases of Mitochondrial Mass and Mitochondrial Genome in Association with Enhanced Oxidative Stress in Human Cells Harboring 4,977 BP-Deleted Mitochondrial DNA 97
DNA Polymerase-[beta] May Be the Main Player for Defective DNA Repair in Aging Rat Neurons 113
Premature Aging and Predisposition to Cancers Caused by Mutations in RecQ Family Helicases 121
Health Span and Life Span in Transgenic Mice with Modulated DNA Repair 132
Part IV. Cellular Maintenance and Stress Response
Inhibition Mechanisms of Bioflavonoids Extracted from the Bark of Pinus maritima on the Expression of Proinflammatory Cytokines 141
Gene Expression and Regulation in the Extended Longevity Phenotypes of Drosophila 157
Impairment of Learning and Memory in Rats Caused by Oxidative Stress and Aging, and Changes in Antioxidative Defense Systems 168
Translocational Inefficiency of Intracellular Proteins in Senescence of Human Diploid Fibroblasts 176
Oxidative Stress and Neurodegeneration in Prion Diseases 182
On the True Role of Oxygen Free Radicals in the Living State, Aging, and Degenerative Disorders 187
Cellular and Molecular Pathogenic Mechanisms of Insulin-Dependent Diabetes Mellitus 200
Part V. Practical Approach for Functional Longevity
Capacity for Recovery and Possible Mechanisms in Immobilization Atrophy of Young and Old Animals 212
Nutrition Interventions in Aging and Age-Associated Disease 226
Exercise at Old Age: Does It Increase or Alleviate Oxidative Stress? 236
Do Antioxidant Strategies Work against Aging and Age-associated Disorders? Propargylamines: A Possible Antioxidant Strategy 248
Antioxidant and Immunostimulating Activities of the Fruiting Bodies of Paecilomyces japonica, a New Type of Cordyceps sp 261
A New Function of Green Tea: Prevention of Lifestyle-related Diseases 274
Anti-aging and Health-promoting Constituents Derived from Traditional Oriental Herbal Remedies: Information Retrieval Using the TradiMed 2000 DB 281
Part VI. Calorie Restriction and Longevity
Caloric Restriction in Primates 287
Calorie Restriction Enhances the Expression of Key Metabolic Enzymes Associated with Protein Renewal during Aging 296
Caloric Restriction in Primates and Relevance to Humans 305
Aging and Caloric Restriction in Nonhuman Primates: Behavioral and in Vivo Brain Imaging Studies 316
The Inflammation Hypothesis of Aging: Molecular Modulation by Calorie Restriction 327
Panel Discussion: Perspectives in Aging Research in the New Millennium 336
Part VII. Poster Papers
A Thermolabile Variant of Methylenetetrahydrofolate Reductase Is a Determinant of Hyperhomocyst(e)inemia in the Elderly 344
Age-related Increase in the Expression of Heat-Shock Protein Genes in the Tissues of Unstressed Rats 345
Amyloid-[beta]-Peptide 25-35 Fragment Modulates the Expression of the Mitochondrial Cytochrome Oxidase Gene 346
Analysis of the Cell Distribution of Endogenous Murine Leukemia Virus in the Brains of SAMR1 and SAMP8 Mice 347
Analysis of Traditional Korean Food Patterns According to the Healthy Longevity Diet Based on the Database of Favorite Korean Foods 348
Analysis of Proteins in Aged Rat Kidney: The Effect of Calorie Restriction 349
Analysis of Redox Status in Serum during Aging 350
Animal Model for Alzheimer's Disease by PS2 Gene Transfer 351
Changes in Growth Factor-induced Signal Transduction during the Aging Process of Human Primary Fibroblasts 352
Contribution of Cyclooxygenase to Age-related Oxidative Stress 353
Control of Mitochondrial Redox Balance by the Mitochondrial NADP[superscript +]-dependent Isocitrate Dehydrogenase 354
The Pro- and Antioxidant Role of Glutathione in Selenite-induced Oxidative Stress and Apoptosis 355
Effects of Aging on Aldosterone Secretion in Rat Zona Glomerulosa Cells 356
Evidence for Differential Structure and Function of Hsp70 Family Members, Mot-1 and Mot-2, in Control of Cellular Senescence 357
Expression of Growth-Related Genes in the Tissues of Aged Rat Brain 358
Expression of Peroxiredoxin in the Skin and Change of Peroxiredoxin by Ultraviolet B Irradiation: A Possible Antioxidant Role against Oxidative Stress in the Skin 359
Genetic Polymorphism of Presenilin-1 Gene and Apolipoprotein E in Korean Elderly with Dementia 361
Impact of Growth Hormone Suppression in the Aging Process and Preliminary Longevity Analysis 362
Increased Expression of Calsenilin in the Brains of Scrapie-infected Mice 363
Induction of Cellular Senescence in Cervical Cancer Cells by Inhibition of HPV Oncogene Expression 364
Induction of Senescence-like Phenotype by an Alkylating Agent, Methyl Methanesulfonante, in Human Diploid Fibroblast 365
Investigation on Natural Peroxynitrite Scavengers 366
Involvement of Caspases in Cell Death Induced by Selenium Compounds in HL-60 Cells 367
Lowered 8-Hydroxyguanine Glycosylase Activity in Senescence-accelerated Mice due to a Single-base Mutation 368
Melatonin-related Compounds Have High Free Radical Scavenging Activity 369
Metabolic Modulation of Cellular Redox Potential Can Improve Cardiac Recovery from Ischemia-Reperfusion Injury 370
New Directions in Communicating Better Nutrition to Older Adults 371
Nitric Oxide Is Implicated in Apoptotic Cell Death Induced by H[subscript 2]O[subscript 2] in C6 Cells 372
Overexpression of Calsenilin in Sporadic Alzheimer's Disease Brain 373
Oxidative Stress Associated Antioxidant Enzyme and Neuroendocrine Markers in Dementia 374
p38 Mitogen-activated Protein Kinase Is Involved in H[subscript 2]O[subscript 2]-induced Phospholipase D Activation in Vascular Smooth Muscle Cells 376
Photoaging in Asian Skin: New Grading System and the Influence of Environmental Factors 377
Plasma Concentrations of an Endogenous Nitric Oxide Synthase Inhibitor, N[superscript G],N[superscript G]-Dimethylarginine: A Novel Risk Factor for Cerebral Infarction in the Elderly 378
Protection of Mitochondria Permeability Transition by Dihydroxybenzaldehyde against Hydroxyl Radicals 379
Risk Factors for Total Mortality in Centenarians in Aichi Prefecture, Japan 380
The Activation Mechanisms of NF-[kappa]B and Inflammatory Enzymes during Aging 381
Vitamin and Mineral Supplement Use among Independent-living Korean and American Older Adults 382
Vitamin D and Estrogen Receptor Gene Polymorphism and Their Interaction Associated with Bone Mineral Density in Korean Postmenopausal Women 384
Vitamin-E Dose-Associated Alterations in Mouse Immune Function 385
Index of Contributors 387

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