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From The CriticsReviewer: Adriana Maria Rosario, MD (Ochsner Clinic Foundation)
Description: This compilation of presentations at a heart failure research symposium reviews molecular mechanisms involved in the development and pathophysiology of heart failure.
Purpose: The book describes the complex molecular mechanisms that lead to heart failure. Topics include signaling molecules from the cell membrane to the nucleus that initiate a complex mechanism of cardiac remodeling, including fetal gene activation, calcium cycling, energy metabolism, fibrosis, and apoptosis.
Audience: The audience is primarily cardiologists and researchers with an interest in heart failure research.
Features: Authors review the molecular changes that occur after a stress or cardiac insult, including how these cardiac injuries promote fetal gene expression and cause abnormal myocardial contractility. Gene therapy is detailed as a therapeutic option in heart failure for the future, including the potential modulation of the apoptotic process. Each chapter ends with the question and answer sessions that took place after each presentation.
Assessment: This book offers an update in the basic mechanisms of heart failure from the premier investigators in the field. Given the current heart failure epidemic, and knowing that despite all the therapeutic advances, mortality is still high, it seems imperative to search further in the pathophysiology of the disease in order to offer better solutions to heart failure patients. The book meets this objective.