Heart Failure: Molecules, Mechanisms and Therapeutic Targets / Edition 1

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Over the past five years, there has been dramatic progress in unravelling the cellular circuitry involved in cardiac failure, as well as in normal cardiac growth, development and apoptosis. These studies have revealed new and unanticipated therapeutic targets in the heart. In addition, recent advances in understanding the role of stem cells in cardiac repair have suggested strategies for cardiac repair and regeneration once thought impossible. This book brings together investigators working on basic mechanisms of cardiac growth, function and dysfunction, along with those searching for novel therapeutic strategies for cardiac disease. The discussions in this book always return to the same basic problem: how to use new data from the biological studies to design novel therapies for the treatment of cardiac dysfunction following myocardial infarction, cardiac hypertrophy, hypertension and other stresses.

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Editorial Reviews

From the Publisher
"…most up-to-date analysis on ways that science might look to reduce the harsh impact of heart disease." (Electric Review, February/March 2007)

"This book offers an update in the basic mechanism of heart failure from the premier investigators in the field." (Doody's Health Services)

Doody's Review Service
Reviewer: Adriana Maria Rosario, MD (Ochsner Clinic Foundation)
Description: This compilation of presentations at a heart failure research symposium reviews molecular mechanisms involved in the development and pathophysiology of heart failure.
Purpose: The book describes the complex molecular mechanisms that lead to heart failure. Topics include signaling molecules from the cell membrane to the nucleus that initiate a complex mechanism of cardiac remodeling, including fetal gene activation, calcium cycling, energy metabolism, fibrosis, and apoptosis.
Audience: The audience is primarily cardiologists and researchers with an interest in heart failure research.
Features: Authors review the molecular changes that occur after a stress or cardiac insult, including how these cardiac injuries promote fetal gene expression and cause abnormal myocardial contractility. Gene therapy is detailed as a therapeutic option in heart failure for the future, including the potential modulation of the apoptotic process. Each chapter ends with the question and answer sessions that took place after each presentation.
Assessment: This book offers an update in the basic mechanisms of heart failure from the premier investigators in the field. Given the current heart failure epidemic, and knowing that despite all the therapeutic advances, mortality is still high, it seems imperative to search further in the pathophysiology of the disease in order to offer better solutions to heart failure patients. The book meets this objective.
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Product Details

  • ISBN-13: 9780470015971
  • Publisher: Wiley
  • Publication date: 9/25/2006
  • Series: Novartis Foundation Symposia Series, #153
  • Edition number: 1
  • Pages: 302
  • Product dimensions: 6.00 (w) x 9.00 (h) x 0.80 (d)

Meet the Author

The Novartis Foundation is an international scientific and educational charity which promotes the study and general knowledge of science and in particular encourages international co-operation in scientific research.

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Table of Contents

Introduction (Eric N. Olson).

Control of cardiac hypertrophy and heart failure by histone acetylation/deacetylation (Eric N. Olson, Johannes Backs and Timothy A. McKinsey) .


A novel mechanism of mechanical stress-induced hypertrophy (Hiroshi Akazawa, Yunzeng Zou and Issei Komuro) .


Controlling cardiomyocyte survival (N. de Jonge, M. J. Goumans, Daan Lips, Rutger Hassink, Eva J. Vlug, Roy van der Meel, Christopher Donald Emmerson, Joppe Nijman, Leon de Windt and Pieter A. Doevendans) .


Mechanisms of angiotensin II-dependent progression to heart failure (Mona Nemer, Nassim Dali-Youcef, Hao Wang, Anne Aries and Pierre Paradis) .


Alterations in myocardial gene expression as a basis for cardiomyopathies and heart failure (Matthew R. Taylor and Michael R. Bristow) .


Role of the insulin-like growth factor 1 (IGF1)/phosphoinositide-3-kinase (PI3K) pathway mediating physiological cardiac hypertrophy (Julie R. McMullen and Seigo Izumo).


Role of Akt in cardiac growth and metabolism(Anthony J. Muslin and Brian DeBosch).


Novel therapy for heart failure and exercise-induced ventricular tachycardia based on ‘fixing’ the leak in ryanodine receptors (Andrew R. Marks).


General discussion I.

Phospholamban as a therapeutic modality in heart failure (Guoxiang Chu and Evangelia G. Kranias).


Sarcomere protein gene mutations and inherited heart disease: a b-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure (Mitsuhiro Kamisago, Joachim P. Schmitt, Dennis McNamara, Christine Seidman and Jonathan G. Seidman).


The cardiomyocyte cell cycle (Pascal J. E. Lafontant and Loren J. Field).


Restoration of cardiac function with progenitor cells (Carmen Urbich, Lothar Rössig and Stefanie Dimmeler).


Signalling pathways in cardiac regeneration (Maria Paola Santini, Nadine Winn and Nadia Rosenthal).


Beyond small molecule drugs for heart failure: prospects for gene therapy (Kenneth R. Chien).


Dual roles of telomerase in cardiac protection and repair (Michael D. Schneider).


Final general discussion.

Closing remarks: historical perspective (Arnold M. Katz).

Index of contributors.

Subject index.

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