Heart Function in Health and Disease: Proceedings of the Cardiovascular Program sponsored by the Council of Cardiac Metabolism of the International Society and Federation of Cardiology during the Regional Meeting of the International Union of Physiologica / Edition 1

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As the majority of cardiovascular deaths are related to myocardial ischemia, it is necessary to understand the various aspects of ischemic heart disease. In this regard, it is noteworthy that ischemic heart disease is commonly associated with atherosclerosis, coronary spasm, as well as thrombosis leading to the development of arrhythmias, cardiovascular cell damage, myocardial infarction, cardiac hypertrophy and congestive heart failure. Furthermore, it is also important to appreciate various physiological, electrophysiological and biochemical processes in the normal heart if we are to understand their significance under pathological situations.
Heart Function in Health and Disease has been organized in five sections to provide an outline of a complex problem in a convenient manner. One section of this book is devoted to shedding light on the restructuring and ontogenic changes in the developing heart whereas in the next section some hypertrophic alterations due to chronic hypoxia are described. The third and fourth sections of this book are concerned with the regulation of cardiac channels as well as signal transduction mechanisms and cardiac electric field. The fifth section contains some pathophysiological events during the development of cardiac hypertrophy and heart failure. All of these areas encompass a significant body of new information that will be invaluable to those who work in the field of cardiovascular sciences, as well as those who treat people with heart disease.
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Product Details

  • ISBN-13: 9780792320524
  • Publisher: Springer US
  • Publication date: 9/5/2007
  • Series: Developments in Cardiovascular Medicine Series, #140
  • Edition description: 1993
  • Edition number: 1
  • Pages: 335
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.81 (d)

Table of Contents

1 Heart story: A view to the past 3
2 Postnatal growth and restructuring of mammalian hearts 23
3 Ontogenetic development of cardiac inotropic responsiveness 31
4 Activation mechanisms of cardiac muscarinic K channels 47
5 Multiple cyclic GMP binding proteins involved in the regulation of cardiac calcium channels 61
6 Participation of the Na[superscript +]-H[superscript +] exchange pathway in cardiac pathology 71
7 Phospholipase D: A new avenue to the phospholipid signalling pathways in the myocardium 79
8 Cardiac pacemaker activity: From single cells to modelling the heart 93
9 Physiology of the cardiac electric field 111
10 Modelling of the cardiac electrical field 127
11 The temporal behaviour of the cardiac electric field 143
12 Computer modelling of cardiac arrhythmias 157
13 Relationship between heart mass and hemoglobin/hematocrit at high altitude - Function or fallacy? 185
14 Functional assessment of the hypertrophic right ventricle in the rat heart 193
15 Chronic hypoxia-induced right ventricular enlargement: Age-dependent changes of collagenous and non-collagenous cardiac protein fractions 209
16 Sarcolemmal cation transport systems in rat hearts acclimatized to high altitude hypoxia, influence of 7-oxo-prostacyclin
17 Effects on the heart of two forms of chronic hypoxia 229
18 Thyroid hormones and cardiac hypertrophy 239
19 Diastolic dysfunction of the heart. Pharmacological strategies for modulating calcium sequestration of the sarcoplasmic reticulum 251
20 Conduit coronary artery structure and function 273
21 Heart failure: A disease of adaptation 287
22 Involvement of sarcolemmal Na[superscript +]-K[superscript +] ATPase in the pathogenesis of heart disease 295
23 Neuroendocrine response to heart failure 307
24 Alterations of extracellular matrix in cardiac atrophy 321
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