The Heart in Diabetes / Edition 1

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Overview

Diabetes is a major public health problem which is expected to affect 160 million people worldwide by the year 2000. Clearly an understanding of the effects of diabetes on the heart is an important step in the development of strategies to reduce the incidence of heart disease for diabetic patients, thus increasing their overall life-expectancy and quality of life.
In this book, the editors bring together the different lines of evidence supportive of the idea of a diabetic cardiomyopathy. The first chapter provides an overview of the impact of cardiac dysfunction on the mortality and morbidity of the diabetic population in general, as well as a presentation of clinical aspects of heart disease in diabetes. This is followed by chapters concerned with the pathological and functional changes that occur in the heart as a result of diabetes and a description of the various therapeutic interventions that are available to reverse the effects of diabetes on the heart. Subsequent chapters focus on changes in protein synthesis, membrane function and intermediary metabolism that take place following the onset of diabetes. Since these alterations precede many of the functional and pathological changes, it may be that the processes responsible for the functional decline and tissue injury are initiated by diabetes-induced changes at the cellular and/or biochemical level.

Clinical manifestations of diabetic cardiomyopathy/ketone body metabolism in the diabetic heart/fatty acid metabolism.

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Editorial Reviews

Booknews
Assembles several different lines of evidence supporting the idea of a diabetic cardiomyopathy and approaches to managing it, to help researchers develop strategies for reducing the incidence of heart disease in diabetic patients. The topics include the pathological alterations of the heart in diabetes mellitus, therapeutic interventions, the effect of diabetes on protein synthesis in the myocardium, cardiac glycogen metabolism, and remodelling subcellular organelles during the development of diabetic cardiomyopathy. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780792340522
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 4/30/1996
  • Series: Developments in Cardiovascular Medicine Series , #185
  • Edition description: 1996
  • Edition number: 1
  • Pages: 278
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.69 (d)

Table of Contents

1. Clinical Manifestations of Diabetic Cardiomyopathy; F.S. Fein. 2. Pathological Alterations of the Heart in Diabetes Mellitus; A. Borczuk, S.M. Factor. 3. Alterations of Cardiac Function, Composition and Rhythm as a Consequence of Diabetes; M. Shanmugam, et al. 4. Therapeutic Interventions in the Diabetic Heart; J.H. McNeill, B. Rodrigues. 5. Effect of Diabetes on Protein Synthesis in the Myocardium; D. Geenen, A. Malhotra. 6. Remodelling of Subcellular Organelles During the Development of Diabetic Cardiomyopathy; N.S. Dhalla, et al. 7. Ketone Body Metabolism in the Diabetic Heart; J.R. Forder. 8. Cardiac Glycogen Metabolism in Diabetes; M. Laughlin. 9. The Effect of Diabetes on Myocardial Glucose Metabolism; J.C. Chatham. 10. Fatty Acid Metabolism in the Heart Following Diabetes; G.D. Lopaschuk. 11. Conclusion; J.C. Chatham, et al. Index.

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