Hematology: Basic Principles and Practice / Edition 4

Hematology: Basic Principles and Practice / Edition 4

by Ronald Hoffman, Leslie E. Silberstein, Sanford J. Shattil, Bruce Furie

ISBN-10: 0443066280

ISBN-13: 9780443066283

Pub. Date: 12/21/2004

Publisher: Elsevier Health Sciences

The fourth edition of this leading text reflects the new direction and growth of the field of hematology as an academic and clinical discipline. Edited and written by practitioners who are the leaders of the field, the book covers both the basic scientific foundations of hematology and its clinical aspects. It provides practitioners with the most comprehensive,

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The fourth edition of this leading text reflects the new direction and growth of the field of hematology as an academic and clinical discipline. Edited and written by practitioners who are the leaders of the field, the book covers both the basic scientific foundations of hematology and its clinical aspects. It provides practitioners with the most comprehensive, authoritative, up-to-date information in hematology. The table of contents has been thoroughly revised with many new chapters added, reflecting the rapidly changing nature of the molecular and cellular areas of the specialty. This definitive resource is the one comprehensive book needed by every practicing hematologist.

• Full color throughout for the first time (color figures in place!)
• E-dition available
• The definitive, complete reference resource for hematologic disorders provides "one-stop shopping" for information; appeals to both practitioners and researchers
• Red "opinion" boxes contain treatment strategies and recommendations by the experts
• Only text to include a section on transplantation
• Clinically oriented focus
• Includes more than 15 new chapters

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Elsevier Health Sciences
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Table of Contents


Chapter 1 Anatomy and Physiology of the Gene
Edward J. Benz, Jr., Andrew Wagner, Nancy Berliner

Chapter 2 Genomic Approaches to the Study of Hematologic Science
Todd Golub and Scott Armstrong

Chapter 3 Protein Synthesis, Processing, and Degradation
Garabet G. Toby and David L. Wiest

Chapter 4 Protein Architecture: Relationship of Form and Function
Alan C. Rigby and Barbara C. Furie

Chapter 5 Regulation of Cellular Response
Benjamin G. Neel and Christopher Carpenter

Chapter 6 Cell Adhesion
Rodger P. McEver

Chapter 7 Control of Cell Division
William M.F. Lee and Chi V. Dang

Chapter 8 Cell Death
David M. Hockenbery and Stanley J. Korsmeyer

Chapter 9 Pharmacogenomics and Hematological Diseases
Loe Kager and William E. Evans


Chapter 10 Overview and Compartmentalization of the Immune System
Leland D. Powell and Linda G. Baum

Chapter 11 B-Cell Development
Kenneth Dorshkind and David J. Rawlings

Chapter 12 T-Cell and NK-Cell Immunity
Carol Clayberger and Alan M. Krensky

Chapter 13 Dendritic Cell Biology
Zbigniew M. Szczepiorkowski and Nina Bhardwhaj

Chapter 14 Regulation of Activation of B and I Lymphocytes
John C. Monroe and Lawrence Turka

Chapter 15 Leukocyte Trafficking
James J. Campbell, Steven Sloan, and Leslie E. Silberstein

Chapter 16 Tolerance and Autoimmunity
Mark J. Shlomchik


Chapter 17 Stem Cell Model of Hematopoiesis
Anskar YH Leung and Catherine M. Verafaillie

Chapter 18 Bone Marrow Microenvironment
Mo Dao and Catherine M. Verfaillie

Chapter 19 The Humeral Regulation of Hematopoiesis
Montaser Shaheen and Hal Broxmeyer

Chapter 20 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
Thalia Papayannopoulou, Alan D’Andrea, Janis Abkowitz, and Anna Rita Migliaccio

Chapter 21 Granulopoiesis and Monocytopoiesis
Arati Khanna-Gupta and Nancy Berliner

Chapter 22 Thrombocytopoiesis
Michael W. Long and Ronald Hoffman

Chapter 23 Thrombocytopenia Due to Decreased Platelet Production
J. B. Opalinska and Alan M. Gewirtz

Chapter 24 Inherited Forms of Bone Marrow Failure
Melvin H. Freedman

Chapter 25 Aplastic Anemia
Neal S. Young and Jaroslaw P. Maciejewski

Chapter 26 Paroxysmal Nocturnal Hemoglobinuria
Rob A. Brodsky

Chapter 27 Pure Red Cell Aplasia
Emmanuel N. Dessypris


Chapter 28 Pathobiology of the Human Erythrocyte and Its Hemoglobins
Martin H. Steinberg, Edward J. Benz, Jr., Henry Adewoye, and Ben Ebert

Chapter 29 Approach to Anemia in the Adult and Child
Peter Marks and Bertil Glader

Chapter 30 Anemia of Chronic Diseases
Lawrence B. Gardner and Edward J. Benz, Jr.

Chapter 31 Pathology of Iron Metabolism
Nancy C. Andrews

Chapter 32 Disorders of Iron Metabolism : Iron Deficiency and Overload
Gary M. Brittenham

Chapter 33 Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
James S. Wiley and Michael R. Moore

Chapter 34 Megablastic Anemias
Aœok C. Anthony

Chapter 35 Thalassemia Syndromes
Bernard G. Forget and Alan R. Cohen

Chapter 36 Pathology of Sickle Cell Disease
Robert P. Hebbel

Chapter 37 Sickle Cell Disease
Stephen H. Embury, Elliot Vichinsky, and Yogen Saunthararajah

Chapter 38 Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
Edward J. Benz, Jr.

Chapter 39 Red Cell Enzymopathies
Xylina T. Gregg and Josef T. Prchal

Chapter 40 Red Cell Membrane Disorders
Patrick G. Gallagher and Petr Jarolim

Chapter 41 Autoimmune Hemolytic Anemias
Melody J. Cunningham and Leslie E. Silberstein

Chapter 42 Extrinsic Nonimmune Hemolytic Anemias
Stanley L. Schrier and Erin Gourley Reid


Chapter 43 Complement Biology and Immunoglobulin
Gregory Kline, Robert Barrington, and Michael C. Carroll

Chapter 44 Normal Phagocyte Structure and Function
Robert L. Baehner

Chapter 45 Eosinophilia, Eosinophil-Associated Diseases, Chronic Eosinophil Leukemia, and the Hypereosinophilic Syndromes
Steven J. Ackerman and Joseph H. Butterfield

Chapter 46 Disorders of Phagocyte Function and Number
Mary C. Dinauer and Thomas D. Coates

Chapter 47 Disorders of Lymphocyte Function
Aileen M. Cleary, Richard A. Insel, and David B. Lewis

Chapter 48 Histiocytic Disorders
Jeffrey M. Lipton and Robert J. Arceci

Chapter 49 Lysosomal Storage Diseases: Perspective and Principles
Gregory A. Grabowski and Nancy Leslie

Chapter 50 Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop

Chapter 51 The Spleen and Its Disorders
Susan B. Shurin

Chapter 52 Basophils, Mast Cells, and Systemic Mastocytosis
Robert I. Parker and Dean D. Metcalfe


Chapter 53 Conventional Cytogenetics and Molecular Cytogenetics in Hematological Malignancies
Gordon Dewald and Rhett P. Ketterling

Chapter 54 The Molecular Basis of Neoplasia
Carol Westbrook

Chapter 55 Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
Stanton Gerson, Kapil N. Bhalla, Steven Grant, Richard Creeger, Nizar Bahlis

Chapter 56 Radiation Therapy in the Treatment of Hematologic Malignancies
Andrea K. Ng and Peter M. Mauch

Chapter 57 Clinical Use of Hematopoietic Growth Factors
Jacob M. Rowe and Irit Avivi

Chapter 58 Radioimmunotherapy for B-Cell and Non-Hodgkin Lymphoma
Thomas E. Witzig

Chapter 59 Pathobiology of Acute Myeloid Leukemia
Brian Huntly and D. Gary Gilliland

Chapter 60 Clinical Manifestations of Acute Myeloid Leukemia
Kenneth B. Miller and Philip R. Daoust

Chapter 61 Therapy for Acute Myeloid Leukemia
Elihu H. Estey and Hagop Kantarijan

Chapter 62 Acute Myeloid Leukemia in Children
Gary V. Dahl and Howard J. Weinstein

Chapter 63 Pathobiology of Acute Lymphoblastic Leukemia
A. Thomas Look and Adolpho Ferrando

Chapter 64 Clinical Manifestations of Acute Lymphoblastic Leukemia
Stacey L. Berg, C. Philip Steuber, and David G. Poplack

Chapter 65 Treatment of Childhood Acute Lymphoblastic Leukemia
Lewis B. Silverman, Stephen E. Sallan, and Harvey J. Cohen

Chapter 66 Acute Lymphoblastic Leukemia in Adults
Dieter Hoelzer and Nicola Gokbudget

Chapter 67 Myelodysplastic Syndrome: Biology and Treatment
Richard Stone and Daniel DeAngelo

Chapter 68 Polycythemia Vera
Ronald Hoffman, Kelty R. Baker and Joe Prchal

Chapter 69 Chronic Myeloid Leukemia
Charles Sawyers and Neil P. Shah

Chapter 70 Myelofibrosis with Myeloid Metaplasia
Ronald Hoffman and Farhad Ravandi-Kashani

Chapter 71 Essential Thrombocythemia
Steven Fruchtman and Ronald Hoffman

Chapter 72 Myelodysplastic Syndromes and Myeloproliferative Syndromes in Children
David M. Loeb, Robert P. Castleberry, and Cindy L. Schwartz

Chapter 73 Pathobiology of Non-Hodgkin Lymphomas
Gianluca Gaidano and Riccardo Dalla-Favera

Chapter 74 Patho-Biology of Hodgkin’s Lymphoma
Stefano A. Pileri, Brunangelo Falini and Harold Stein

Chapter 75 Hodgkin’s Disease: Clinical Manifestations, Staging, and Therapy
Volker Diehl, Daniel Re, and Andreas Josting

Chapter 76 The Pathologic Basis for the Classification of Non-Hodgkin Lymphomas
Elaine Jaffe and Stefania Piltaluga

Chapter 77 Clinical Manifestations, Staging, and Treatment of Non-Hodgkin Lymphoma John G. Gribben and Ann S. La Casce

Chapter 78 Malignant Lymphomas in Childhood
John T. Sandlund, Jr.Michael P. Link

Chapter 79 Chronic Lymphocytic Leukemia
Dilip V. Patel and Kanti R. Rai

Chapter 80 Hairy Cell Leukemia
Annaadriana Zakanja, LoAnne C. Petersen, and Martin S. Tallman

Chapter 81 Cutaneous T-Cell Lymphomas
Timothy M. Kuzel, Joan Guitart, and Steven T. Rosen

Chapter 82 AIDS-Related Lymphomas
David T. Scadden

Chapter 83 Multiple Myeloma and Other Plasma Cell Disorders
Guido Tricot

Chapter 84 Immunoglobulin Light Chain Amyloidosis (Primary Amyloidosis, AL)
Morrie A. Gertz, Martha Q. Lacy, Angela Dispenzien

Chapter 85 Atypical Immune Lymphoproliferations
Timothy C. Greiner and Thomas G. Gross

Chapter 86 Clinical Approaches to Infections in the Compromised Host
Jo-Anne H. van Burik

Chapter 87 Nutritional Support of Patients with Hematologic Malignancies
Polly Lenssen and Saundra N. Aker

Chapter 88 Psychosocial Aspects of Hematologic Disorders
Ruth McCorkle, Siew Tzuh Tang, Jeannie Pasacreta

Chapter 89 Pain Management and Antiemetic Therapy in Hematologic Disorders
Janet L. Abrahm, Lauren Dias, and Bridget Fowler

Chapter 90 Palliative Care Janet L. Abrahm and Barbara Sourkes

Chapter 91 Indwelling Access Devices
Janet L. Abrahm and Linda M. Pellerin

Chapter 92 Late Complications of Hematologic Diseases and Their Therapies
Wendy Landier and Smita Bhatia


Chapter 93 Hematopoietic Stem Cell Transplantation for Acquired Nonmalignant Diseases and Myelodysplastic Syndrome
William Tse and H. Joachim Deeg

Chapter 94 Hematopoietic Cell Transplant for Immune Deficiences and Genetic Diseases
Stella M. Davies

Chapter 95 Results of Allogeneic Hematopoietic Cell Transplant for Hematologic Malignancies
Andrea Bacigalupo

Chapter 96 Autologous Transplant for Hematologic malignancies and Solio Tumors
Stephen J. Forman and Jeffery R. Schriber

Chapter 97 Unrelated Donor Stem Cell Transplantation Therapy
Effie W. Petersdorf and Claudio Anasetti

Chapter 98 Umbilical Cord Blood Transplantation
Juliet N. Barker and John E. Wagner

Chapter 99 Preparative Regimens for Hematopoietic Cell Transplantation
Marcos de Lima and Sergio Giralt

Chapter 100 Graft-versus-Host Disease and Graft-versus-Leukemia
Pavan Reddy and James L.M. Ferrara

Chapter 101 Graft Engineering to Enhance Engraftment, Reduce Graft-versus-Host Disease and Provide a Graft-versus-Tumor Effect
Catherine M. Bollard and Adrian P. Gee

Chapter 102 Gene Transfer for Hematologic Disorders
Katherine A. High and Malcolm K. Brenner

Chapter 103 Experimental Cell Therapy
Robert S. Negrin

Chapter 104 Complications After Hematopoietic Cell Transplantation
Daniel J. Weisdorf


Chapter 105 Megakaryocyte and Platelet Structure
Joseph E. Italiano and John Hartwig

Chapter 106 The Molecular Basis for Platelet Function
Edward F. Plow and Charles S. Abrams

Chapter 107 The Molecular Basis for Platelet Activation
Lawrence F. Brass

Chapter 108 The Blood Vessel Wall
Aly Karsan and John M. Harlan

Chapter 109 Molecular Basis of Blood Coagulation
Bruce Furie and Barbara C. Furie

Chapter 110 Molecular and Cellular Basis of Fibrinolysis
H. Roger Lijnen and Désiré Collen

Chapter 111 Regulatory Mechanisms in Hemostasis: Natural Anticoagulants
Charles T. Esmon

Chapter 112 Clinical Evaluation of Hemorrhagic Disorders: Bleeding History and Differential Diagnosis of Pupura
Barry S. Coller and Paul I. Schniederman

Chapter 113 Laboratory Evaluation of Hemostatic Disorders
Jacob H. Rand and Lisa Senzel

Chapter 114 Structure, Biology, and Genetics of Factor VIII
Randal J. Kaufman and Stylianos E. Antonarakis

Chapter 115 Biochemistry of Factor IX and Molecular Biology of Hemophilia B
S. Jamie Freedman and Bruce Furie

Chapter 116 Clinical Aspects and Therapy of Hemophilia
Jay Nelson Lozier and Craig M. Kessler

Chapter 117 Inhibitors in Hemophilia
Donald I. Feinstein

Chapter 118 Other Clotting Factor Deficiencies
Harold R. Roberts and Miguel A. Escobar

Chapter 119 Disorders of Fibrinogen
José Martinez and Andres Ferber

Chapter 120 Structure, Biology, and Genetics of von Willebrand Factor
David Ginsburg and Denisa D. Wagner

Chapter 121 von Willebrand Disease: Clinical Aspects and Therapy
Gilbert C. White, II, and J. Evan Sadler

Chapter 122 Vitamin K: Metabolism and Disorders
Barbara C. Furie and Bruce Furie

Chapter 123 Inhibitors of Blood Coagulation
Donald I. Feinstein

Chapter 124 Disseminated Intrvascular Coagulation
Howard A. Liebman and Ilene C. Weitz

Chapter 125 Hemostatic Defects Associated with Dysproteinemias
Howard A. Liebman

Chapter 126 Disorders of Coagulation in the Neonate
Leonardo R. Brandao and Donna DiMichele

Chapter 127 Hypercoagulable States
Kenneth A. Bauer

Chapter 128 Venous Thromboembolism
Mark A. Crowther and Jeffrey S. Ginsberg

Chapter 129 Arterial Thromboembolism
Mark A. Crowther and Jeffrey S. Ginsberg

Chapter 130 Anticoagulation and Thrombolytic Therapy
Jeffrey I. Weitz

Chapter 131 Immune Thrombocytopenic Purpura, Neonatal Alloimmune Thrombocytopenia, and Posttransfusion Purpura
James Bussel and Douglas Cines

Chapter 132 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome
Keith R. McCrae, J Evan Sadler, and Douglas Cines

Chapter 133 Thrombocytopenia Due to Platelet Destruction and Hypersplenism
Theodore E. Warkentin and John G. Kelton

Chapter 134 Hereditary Disorders of Platelet Function
Joel S. Bennett

Chapter 135 Acquired Disorders of Platelet Function
Jose Lopez and Perumal Thiagarajan


Chapter 136 Human Blood Group Anitgens and Antibodies Part 1: Carbohydrate Determinants Part 2: Protein Determinants
Marion E. Reid and Martin L. Olsson

Chapter 137 Human Platelet Antigens
Thomas J. Kunicki and Diane J. Nugent

Chapter 138 Human Leukocyte Antigen (HLA) and Human Neutrophil Antigen (HNA) Systems Ena Wang, Francesco M. Marincola, and David Stroncek

Chapter 139 Principles of Red Blood Cell Transfusion
Paul M. Ness and Margot S. Kruskall

Chapter 140 Principles of Platelet Transfusion Therapy
Thomas S. Kickler

Chapter 141 Principles of Neutrophil (Granulocyte) Transfusions
Ronald G. Strauss

Chapter 142 Transfusion of Plasma Derivatives: Fresh-Frozen Plasma,
Cryoprecipitate, Albumin, and Immunoglobulins
Cassandra D. Josephson and Christopher D. Hillyer

Chapter 143 Preparation of Plasma-Derived and Recombinant Human Plasma Proteins
William N. Drohan and David B. Clark

Chapter 144 Transfusion Therapy for Coagulation factor Deficiencies
Catherine S. Manno and Peter Larson

Chapter 145 Hemapheresis and Cellular Therapy
Ellen F. Lazarus and Harvey G. Klein

Chapter 146 Practical Aspects of Stem Cell Collection
Scott D. Rowley, Stuart L. Goldberg, and Jack Hsu

Chapter 147 Transfusion Reactions
Edward L. Snyder and YanYun Wu

Chapter 148 Transfusion-Transmitted Diseases
Eberhard W. Fiebig, Michael P. Busch and Jay E. Menitove

Chapter 149 Transfusion Medicine in Hematopoietic Stem Cell and Solid Organ Transplantation Richard M. Kaufman, Jerome Ritz and Walter H. Dzik

Chapter 150 Red Blood Cell Substitutes
Robert M. Winslow


Chapter 151 Hematologic Manifestations of Systemic Disease: Liver and Renal Disease
Rachel Rosovsky and Peter W. Marks

Chapter 152 Hematologic Manifestations of Systemic Disease: Infection, Chronic Inflammation, and Cancer
Peter W. Marks and David S. Rosenthal

Chapter 153 Hematologic Manifestations of AIDS
David H. Henry and James A. Hoxie

Chapter 154 Hematologic Problems in the Surgical Patient: Bleeding and Thrombosis
Mark T. Reding and Nigel S. Key

Chapter 155 Hematologic Aspects of Pregnancy
Edward J. Benz, Jr.

Chapter 156 Hematologic Manifestations of Childhood Illness
A. Kim Ritchey and Frank G. Keller


Chapter 157 Bone Marrow Examination
Daniel H. Ryan and Harvey J. Cohen

Chapter 158 Automated Analysis of Blood Cells
Raymond E. Felgar and Daniel H. Ryan

Chapter 159 Laboratory Detection of Hemoglobinopathies and Thalassemias
Martin H. Steinberg and David Chui

Chapter 160 Antenatal Diagnosis of Hematologic Disorders
Kim Kramer and Harvey J. Cohen

Chapter 161 Use of Molecular Techniques in the Analysis of Hematologic Diseases
Michele Paessler and Adam Bagg

Chapter 162 Molecular Imaging in Hematology
Francis G. Blankenberg

Appendix Normal Blood Values: Selected Reference Values for Neonatal, Pediatric, and Adult Populations
Sharon M. Geaghan

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