Hematopoiesis: Long-term Effects of Chemotherapy and Radiation

Overview

Cytotoxic injury to the bone marrow from drugs, chemicals, and radiation is an important problem. This reference critically assesses the implications of bone marrow damage by analyzing mechanisms of myelosuppression, possible mutagenic action, capacity to induce chromosome abnormalities, and effects on the immune system and other tissues. Hematopoiesis places clinical and experimental observations in the context of cell biology ... evaluates the effects of treatment, disease evolution, and the induced ...
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Overview

Cytotoxic injury to the bone marrow from drugs, chemicals, and radiation is an important problem. This reference critically assesses the implications of bone marrow damage by analyzing mechanisms of myelosuppression, possible mutagenic action, capacity to induce chromosome abnormalities, and effects on the immune system and other tissues. Hematopoiesis places clinical and experimental observations in the context of cell biology ... evaluates the effects of treatment, disease evolution, and the induced proliferative stress on the hemopoietic system ... concentrates on hemopoiesis within a clinical framework relating to immunology, cytogenetics, and leukemogenesis ... presents the subject in a logical sequence from fundamentals to future directions for research ... and looks at new research approaches to the therapy of malignancies. Including some 1,200 citations of pertinent literature plus many drawings, tables, and photographs, Hematopoiesis serves as an indispensable resource for hematologists, oncologists, cell and molecular biologists, immunologists, internists, radiation therapists, and bone marrow transplantation specialists.
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Product Details

  • ISBN-13: 9780824779382
  • Publisher: Taylor & Francis
  • Publication date: 4/28/1988
  • Series: Hematology Series , #8
  • Pages: 440
  • Product dimensions: 6.25 (w) x 9.25 (h) x 1.00 (d)

Table of Contents

Series Introduction iii
Preface v
Contributors vii
1. The Hemopoietic System: Structure and Regulation 1
I. Introduction 1
II. The Structure of Hemopoiesis 3
III. Structure of the Stem Cell Population 7
IV. Regulation of Stem Cells 7
V. Regulation of Progenitor Cells 12
VI. Microarchitecture of Hemopoietic Tissue 17
VII. Conclusion 20
References 21
2. Hemopoietic Microenvironments 27
I. Introduction 27
II. Exchange of Information Among Neighboring Hemopoietic Cells 28
III. Regulation of Hemopoiesis by Stromal Cells 36
IV. Summary 48
References 49
3. Myelosuppressive Effects of Antineoplastic Chemotherapy 63
I. Introduction 63
II. Mechanisms of Myelosuppression 64
III. Kinetics of Myelosuppression 66
IV. Evaluation of Myelosuppression 68
V. Future Directions 69
VI. Summary 70
References 71
4. Long-Term Bone Marrow Damage After Cytotoxic Treatment: Stem Cells and Microenvironment 75
I. Introduction 75
II. Stem Cell Damage 76
III. Environmental Damage 81
IV. Evaluation of Long-Term Damage 83
V. Summary 88
References 88
5. Long-Term Bone Marrow Damage After Irradiation 93
I. Experimental Delayed Effects of Radiation on Bone Marrow in Animals 93
II. Delayed Effects of Radiation on the Bone Marrow in Humans 111
III. Overview of Delayed Effects of Radiation Injury on Hemopoietic Tissues 119
References 124
6. Drugs and Chemicals as Agents of Bone Marrow Failure 131
I. Clinical Observations 131
II. Three Examples 133
III. Pathogenic Mechanisms 142
IV. Conclusion: Anomalies 147
References 149
7. Induced Chromosome Damage After Irradiation and Cytotoxic Drugs 159
I. Introduction 159
II. Cytogenetic Studies in Peripheral Blood Lymphocytes 159
III. Long-Term Cytogenetic Effects Associated with Cytostatic Therapy-Related Leukemia 180
References 191
8. Mutational Effects of Radiotherapy and Chemotherapy 203
I. Introduction 203
II. Experimental Studies 204
III. Clinical Studies 209
IV. Molecular Changes 211
V. Consequences of Mutagenesis 213
References 213
9. Long-Term Damage to the Immune System After Irradiation 217
I. Introduction 217
II. The Effect of Ionizing Radiation on Tissues 218
III. The Immune System 219
IV. The Response of the Immune System to Irradiation 220
V. Delayed Effects of Irradiation on the Immune Function in Humans 223
References 236
10. Considerations of Long-Term Radiation Injury in Nonhemopoietic Tissues 247
I. Introduction 247
II. Tissue Renewal 248
III. Temporal Expression of Injury 249
IV. Dose-Response Curves 251
V. Dose Fractionation and Dose Rate 253
VI. Lung 256
VII. Testis 262
VIII. Ovary 266
IX. Eye 267
X. Thyroid 268
XI. Growth Retardation 269
XII. Conclusions 272
References 272
11. Long-Term Bone Marrow Damage After Treatment for Acute Lymphoblastic Leukemia 279
I. Introduction 279
II. Studies of Progenitor Cells 280
III. Studies of Stromal Cells 280
IV. Evaluation of Residual Defects 284
References 286
12. Long-Term Bone Marrow Damage After Acute Nonlymphocytic Leukemia 289
I. Current Trends in Therapy 289
II. Effects of Commonly Used Agents on Hemopoietic Cells 290
III. Progenitor Cell Assays in Leukemic Patients 292
IV. Etiology of Residual Defects 297
References 298
13. Long-Term Bone Marrow Damage After Treatment for Lymphomas 301
I. Long-Term Bone Marrow Damage Induced by Radiotherapy 301
II. Long-Term Bone Marrow Damage Induced by Chemotherapy 310
III. Summary 313
References 315
14. Long-Term Hemopoietic Damage After Cytotoxic Drug Therapy for Solid Tumors 325
I. Introduction 325
II. The Stem Cell Compartment 325
III. Effects of Cytotoxic Drugs on Stem Cells 326
IV. Experimental Long-Term Damage 328
V. Persistent Damage in Patients 328
VI. Evaluation of the Persistent Damage 334
References 335
15. Hemopoietic Engraftment and Differentiation After Bone Marrow Transplantation 339
I. Introduction 339
II. In Vitro Analysis of Human Hemopoietic Stem Cell Differentiation 340
III. Experimental Analysis of Engraftment-Stem Cells, Microenvironment, and Genetic Resistance 343
IV. Hemopoiesis Following Bone Marrow Transplantation in Humans 345
V. T Cell Depletion and Graft Failure 347
VI. Future Directions 349
References 350
16. The Origin of Bone Marrow Stroma After Transplantation: Implications for Graft Failure 357
I. Introduction 357
II. Origins of Stromal Cells After Transplantation 358
III. Implications for Graft Failure 361
IV. Conclusion 369
References 370
17. Conditions Affecting the Growth of Hemopoietic Progenitors After Bone Marrow Transplantation 377
I. Introduction 377
II. Characterization of Hemopoiesis After Bone Marrow Transplantation 377
III. Influence of the Bone Marrow Transplant Inoculum 381
IV. Influence of Host Parameters 382
V. Support of Megakaryocyte Growth in Culture 383
VI. Summary 385
References 385
18. Recent Advances in the Knowledge of the Hemopoietic System: Possible Ways of Correcting Long-Term Damage 389
I. Introduction 389
II. Development of Lineage- or Stage-Specific Cytotoxic Agents 390
III. Biological Response Modifiers: Their Role in Treatment 396
References 400
19. Bone Marrow Function: Recent Progress and Future Directions 403
I. Growth Regulators: Factors and Cells 403
II. Immunological Alterations 405
III. Secondary Malignancies 405
IV. New Therapeutic Approaches 405
Index 407
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