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Hematopoietic Stem Cell Therapy

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This book will be the only current practical guide to a widely used procedure for treating leukemias and disseminated cancers. The contents are organized chronologically, to serve as a step-by-step guide throughout the transplant process. Comprehensive yet concise, it emphasizes the latest techniques, such as peripheral blood stem cell grafts.

The book contains black-and-white illustrations.

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2000-09-08 Hardcover New This book will be the only current practical guide to a widely used procedure for treating leukemias and disseminated cancers. The contents are ... organized chronologically, to serve as a step-by-step guide throughout the transplant process. Comprehensive yet concise, it emphasizes the latest techniques, such as peripheral blood stem cell grafts. Read more Show Less

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Overview

This book will be the only current practical guide to a widely used procedure for treating leukemias and disseminated cancers. The contents are organized chronologically, to serve as a step-by-step guide throughout the transplant process. Comprehensive yet concise, it emphasizes the latest techniques, such as peripheral blood stem cell grafts.

The book contains black-and-white illustrations.

Read More Show Less

Editorial Reviews

New England Journal Of Medicine
The strength of this book lies in its practical and readable approach to hematopoietic stem-cell transplantation. All the authors are close to their subject matter, and many are well-established experts. Chapters on stem-cell biology, the history of transplantation, and the excitement and future of hematopoietic stem-cell therapy would have further embellished this otherwise highly informative textbook, which I recommend for the libraries of specialists in this technique, their trainees, and referring physicians.
Booknews
This text summarizes the current state of knowledge of the management of the transplant patient. A series of presentations mirror the progress of a patient from diagnosis, through HSCT, to post-transplant complication situations commonly encountered in the real world of the practitioner. The 65 chapters begin by outlining the approach to the patient with a variety of diseases treated by high-dose chemotherapy and HSCT, as well as the specific issues of transplantation. They then focus on the specifics of the preparation of the patient and donor for the procedure itself; the process, the conditioning regimen, and the expected post-transplant and longer term problems; and possible therapies for relapse and/or additional treatments. Finally, they address important issues such as psychosocial evaluation, HSCT nursing, data management, statistical methods and analyses, economics, and the regulatory environment. Edited by Ball and Ping Law (both of the blood and marrow transplantation division, U. of California, San Diego), and John Lister (Western Pennsylvania Cancer Institute). Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780443076220
  • Publisher: Elsevier Health Sciences
  • Publication date: 8/28/2000
  • Edition number: 1
  • Pages: 757
  • Product dimensions: 8.80 (w) x 11.20 (h) x 1.50 (d)

Table of Contents

SECTION I: ISSUES RELEVANT TO THE PRE-TRANSPLANT PERIOD
Clinical Indications
Aplastic Anemia
Acute Myelogenous Leukemia
Acute Lymphoblastic Leukemia
Chronic Myelogenous Leukemia
Myelodysplasia
Hodgkin Disease
Lymphoma
Multiple Myeloma
Chronic Lymphocytic Leukemia
Breast Cancer
Ovarian Cancer
Childhood Solid Tumors
Germ Cell Tumors
Hematopoietic Stem Cell Transplantation for Treatment of Congenital Immunodeficiencies
Metabolic Diseases
Hemoglobinopathies
Gaucher Disease
Hematopoietic Stem Cell Transplantation for Severe Autoimmune Diseases: Know Thyself
In Utero Transplantation
Evaluation of the Transplant Candidate
Evaluation of Patients before Hematopoietic Stem Cell Transplantation
Donor Selection and Evaluation
Histocompatibility
Choice of Donor: Immunogenetic and Functional Considerations
Vascular Access
Long-Term Venous Access During Hematopoietic Stem Cell Transplant
Graft Procurement
Bone Marrow Harvesting
Peripheral Blood Progenitor Cell Mobilization and Collection
Cord Blood Stem Cells
Stem Cell Quantification
Stem Cell Quantification: The ISHAGE Guidelines for CD34+ DeterminationApplications in Autologous and Allogeneic Blood and Marrow Transplantation
Graft Engineering Mechanics
Graft Processing, Storage and Infusion
Purging of Contaminating and Tumor Cells
T-Cell Depletion and Allograft Engineering
Immunomodulation After Transplantation
Ex Vivo Stem Cell Expansion
Hematopoietic Stem Cells as Targets for Gene Therapy
SECTION II: ISSUES RELEVANT TO THE IMMEDIATE TRANSPLANT PERIOD
Treatment Regimens
High Dose Chemotherapy Regimens for Use with Autologous or Allogeneic Hematopoietic Stem Cell Support
Choice of Conditioning Regimens
Infection Prophylaxis
Viral Infections
Bacteria
Fungi and Other Organisms
Graft-Versus-Host Disease Prophylaxis
Graft-Versus-Host Disease Prophylaxis
Use of Hematopoietic Growth Factors
Use of Hematopoietic Growth Factors
Coagulation Issues
Coagulation Issues
Nutritional Support
Nutritional Support
Section III: Complications
The Immediate Post-Transplantation Period
Infection
Failure of Engraftment
Therapy of Acute Graft-Versus-Host Disease
Liver Disease in Hematopoietic Stem Cell Transplantation Recipients
Mucositis and other Gastrointestinal Complications
Respiratory Complications
Neurological Complications
Transfusion Support in Hematopoietic Stem Cell Transplantation
Surgical Emergencies
Later Onset
Late Graft Failure
Infection and Immunization
Chronic Graft-Versus-Host Disease
Endocrine and Metabolic Complications
Relapse After Hematopoietic Stem Cell Transplantation: Mechanisms and Treatment
Myelodysplasia and Second Malignancies
Section IV: Post-Transplant Therapy
Conventional Biologic Therapy
Biologic Therapy After Stem Cell Transplantation
Cytotoxic Therapy
Post-transplant Cytotoxic Therapy
Section V: Associated Issues
Psychological Considerations
Psychosocial Considerations: A Family Approach to Patient Care
Specialized Nursing
Specialized Nursing
Coordination and Data Collection
Coordination and Data Collection
Biostatistics
Biostatistics
The Economics of Bone Marrow Transplantation
Economics
Section VI: Regulatory Issues
Regulation of Hematopoietic Stem Cell Therapy
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