Henry's Clinical Diagnosis and Management by Laboratory Methods / Edition 21

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Overview

Required reading in clinical pathology since 1908! Comprehensive coverage gives you an in-depth understanding of lab test selection and interpretation of results. A new full-color layout makes reference much easier. What's more, new chapters on laboratory regulations, nutrition, point-of-care testing, bioterrorism, proteomics, microarray analysis, and the human genome project - as well as a completely new section on cancer testing and meticulous updates from cover to cover - put all the latest, most essential knowledge at your fingertips.

  • Describes the scientific foundation, and clinical application of today's complete range of laboratory tests.
  • Delivers quick and easy access to information with a superb organization that lends itself to continuous reading as well as specific, on-the-spot referencing of a particular problem or condition.


  • Presents a new full-color layout, many new color illustrations and visual aids, and a new organ-system organization to make reference easier and faster.
  • Provides new chapters on Proteomics, Microarray Analysis, and Human Genome Project in Laboratory-Based Diagnostics - authored by pioneering experts who helped originate these techniques.
  • Delivers a new chapter on Laboratory Regulations that details stringent new guidelines in the U.S. and abroad (such as CLIA88 and HIPAA), inspection, accreditation, and proficiency testing.
  • Includes a completely new section on Cancer Testing that covers all aspects of molecular cancer testing, oncoproteins and early tumor detection, and tumor markers.
  • Incorporates sweeping updates on instrumentation and clinical laboratory automation ·medicolegal aspects of environmental toxicology, occupational exposures, and workplace/employment drug testing · molecular microbiology testing · bioterrorism · nutritional status testing · point-of-care testing · and many other evolving topics.
  • Offers an increased emphasis on error detection, correction, and prevention as well as cost-effective test selection.


  • With 117 additional contributing experts.
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Editorial Reviews

Doody's Review Service
Reviewer: Valerie L. Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This is the 21st edition of a recognized authoritative resource on all matters related to laboratory medicine. The previous edition was published in 2001.
Purpose: This book remains the recognized authoritative book for laboratory medicine. Its purpose has been to seamlessly integrate laboratory testing with clinical care. These worthy objectives are well met by this edition. Furthermore, this edition has upheld superbly the longstanding tradition of excellence associated with this book.
Audience: This book is useful for anyone involved in medicine. While the obvious loyal audience remains laboratory medicine folks (CLSs, pathologists, doctoral scientists involved in clinical laboratory testing), this book certainly would appeal to anyone who orders and interprets laboratory tests while caring for patients. In other words, this would appeal to a broad audience involved with healthcare. he authors are all recognized authorities in their respective areas.
Features: My first impression with this edition was that Henry's (as we affectionately call it) had undergone a makeover. This book is absolutely beautiful — color galore, color photomicrographs everywhere, and color gradient shaded sections corresponding to topics. The cover itself has gorgeous color pictures — for a minute there I thought I was looking at a hematology or microbiology atlas. Of course, all the excellent features expected of Henry's are here. Not only are there updates of the various sections, there are also two brand new sections, one on hemostasis and thrombosis and one on clinical pathology of cancer. A new appendix, "common chimeric genes identified in human malignancies," ought to help many of us confronted with the ever evolving alphabet soup of what to look for when evaluating which malignancy. I was quite impressed with the high quality and up-to-date content.
Assessment: This is truly a comprehensive resource for all things related to laboratory medicine. My only (minor) gripes: the print is small (8 or 10 point), and the book is heavy. But these are very minor irritations to put up with when faced with the grandeur and wealth of information contained within. Just get it.
From the Publisher
"A wonderful, clear, practical and thorough reference book for a multidisciplinary pathology laboratory. It contains a wealth of practical laboratory experience." BMA Awards 2007

"In my opinion,Clinical Diagnosis continues to be the best reference for clinical pathology. I strongly recommend it to those studying clinical pathology, as well as those interested in various aspects of interpreting laboratory tests as they apply to clinical care. I especially recommend that those owning Clinical Diagnosis older than the 20th edition should purchase this edition, since it is much improved and contains new material. Few textbooks have been published as long as Clinical Diagnosis. This edition ensures that it will continue into a second century of publication." JAMA, April 25, 2007 - Vol 297, No. 16

"This book remains the recognized authoritative book for laboratory medicine. This edition has upheld superbly the longstanding tradition of excellence associated with this book. Just get it." Doody's, March 2007

"Clinical Diagnosis continues to be the best reference for clinical pathology." JAMA, 2008

REVIEW OF PREVIOUS EDITION (20e)
"The definitive reference in the field of clinical pathology...Required for both beginners and experts alike." JAMA

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Product Details

  • ISBN-13: 9781416002871
  • Publisher: Elsevier Health Sciences
  • Publication date: 7/28/2006
  • Edition description: Older Edition
  • Edition number: 21
  • Pages: 1472
  • Product dimensions: 8.90 (w) x 10.90 (h) x 2.30 (d)

Table of Contents

PART I: The Clinical Laboratory

1. The Clinical Laboratory: Organization, Purpose and Practice

2. Laboratory Regulations

3. Principles of Instrumentation

4. Clinical Laboratory Automation

5. Interpreting Laboratory Results

6. Informatics, Imaging and Interoperability

7. Laboratory Statistics

8. Clinical Laboratory Quality Assurance

PART II: Clinical Chemistry

9. Evaluation of Renal Function, Water, Electrolytes, Acid-Base Balance and Blood Gases

10. Metabolic Intermediates, Inorganic Ions and Biochemical Markers of Bone Metabolism

11. Carbohydrates

12. Lipids and Dyslipoproteinemia

13. Specific Proteins

14. Evaluation of Liver Function and Injury

15. Protein Markers of Disease

16. Evaluation of Endocrine Function

17. Toxicology and Therapeutic Drug Monitoring

18. Nutrition

PART III: Urine and Other Body Fluids

19. Basic Examination of Urine

20. Cerebrospinal, Synovial, and Serious Body Fluids

21. Andrology Laboratory and Fertility Assessment

22. Laboratory Management of Assisted Reproductive Technology

23. Laboratory Aspects of Gestation Management

24. Laboratory Diagnosis of Gastrointestinal Tract and Pancreatic Disorders

PART IV: Hematology, Coagulation and Transfusion Medicine

25. Basic Examination of Blood

26. Hematopoiesis

27. Erythrocytic Disorders

28. Leukocytic Disorders

29. Blood Platelets

30. Coagulation, Fibrinolysis and Hypercoagulation

31. Immunohematology

32. Transfusion Medicine

33. Hemapheresis

34. Tissue Banking and Progenitor Cell

35. Point-of-Care Testing (POCT)

PART V: Immunology and Immunopathy

36. Overview of the Immune System and Immunologic Disorders

37. Immunoassays and Immunochemistry

38. Laboratory Evaluation of the Cellular Immune System

39. Laboratory Evaluation of Immunoglobin Function and Humoral Immunity

40. Complement and Kinins: Mediators of Inflammation

41. Cytokines and Adhesion Molecules

42. HLA: The Major Histocompatibility Complex of Man

43. The Major Histocompatibility Complex and Disease

44. Immunodeficiency Disorders

45. Clinical and Laboratory Evaluation of Systemic Rheumatic Diseases

46. Vasculitis

47. Organ-Specific Autoimmune Diseases

48. Allergic Diseases

PART VI: Medical Microbiology

49. Viral Infections

50. Chlamydial, Rickettsial, and Mycoplasmal Infections

51. Medical Microbiology

52. In Vitro Testing of Antimicrobial Agents

53. Spirochete Infections

54. Mycobacteria

55. Mycotic Diseases

56. Medical Parasitology

57. Molecular Pathology of Infectious Diseases

58. Specimen Collection and Handling for Diagnosis of Infectious Diseases

59. Bioterrorism

PART VII: Molecular Pathology

60. An Introduction to Molecular Pathology

61. Molecular Diagnostics: Basic Principles and Techniques

62. Polymerase Chain Reaction (PCR) and Other Amplification Technology

63. Hybridization Array Technology

64. Applications for Cytogenetics in Modern Pathology

65. Establishing a Molecular Diagnostics Laboratory

66. Molecular Techniques in the Hematopoietic Neoplasms

67. Molecular Diagnosis of Genetic Diseases

68. Forensic Identity Testing by DNA Analysis

69. Proteomics

70. Microarray Analysis

71. Human Genome Project in Laboratory-Based Diagnostics

PART VIII: Cancer Testing

72. Molecular Testing

73. Oncoproteins and Early Tumor Detection

74. Diagnosis and Management of Cancer Using Serologic Tumor Markers

75. Use of DNA Polymorphism and Other Genetic Markers

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Sort by: Showing all of 3 Customer Reviews
  • Posted November 11, 2008

    Highly recommended

    An excellent addition to your reference library, this text offers a bounty of useful information regarding testing and disease processes. If I can't find answers in Robbins, I turn to Henry.

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    Posted January 16, 2009

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    Posted January 26, 2009

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