Hepatology: A Textbook of Liver Disease / Edition 4

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The thoroughly revised New Edition presents definitive coverage of liver disease from over 100 expert contributors. Streamlined to cover the scientific aspects of liver disease only as they apply to immediate clinical implications, this 2-volume resource presents information on pathology, pathophysiology, and clinical diagnosis and management in a readable, engaging format. From normal liver function and the systemic effects of liver dysfunction, through etiology, clinical features, diagnosis, and treatment, you'll find accurate, up-to-date information page after page.

• The chapter on hepatitis has been divided into three complete chapters devoted to each virus - hepatitis A and E, hepatitis B and hepatitis C

• An entirely new chapter has been added on other hepatitis viruses

• 38 new contributors bring their expertise to this edition

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Willem J de Villiers, MD, PhD, MHCM (University of Kentucky College of Medicine)
Description: This long-awaited 4th edition (the previous edition was published in 1996) of this venerable, authoritative textbook of liver disease edited by Zakim and Boyer, was a pleasure to review. The book, thoroughly updated and current, follows the same general, trusted guidelines as the previous editions.
Purpose: The book is intended as an up-to-date comprehensive textbook of liver disease and is aimed particularly at gastroenterology and hepatology trainees, subspecialists and transplant hepatologists. This edition is evidence of both the editors' and the textbook's durability and reputation. The topics are covered exhaustively with numerous relevant references which are especially helpful because of the ever-quickening pace of medicine.
Audience: The authors and their extensive panel of contributors (predominantly from the United States) are outstanding authorities in their respective fields. The book contains a wealth of information and is correctly targeted more at gastroenterologists and hepatologists as a reference textbook.
Features: This 2-volume book covers the entire spectrum of liver diseases. Volume 1, titled Normal Liver Function and Systemic Effects of Liver Dysfunction and contains sections on cell biology, biochemistry, and physiology of liver function; systemic effects of liver disease; and laboratory methods for evaluation of patients with liver disease. Sections in volume 2 (Etiologies, Clinical Features, Diagnosis, and Treatment of Specific Liver Diseases) covers toxic injury to the liver and associated diseases; diagnosis and management of liver disease due to infectious agents; diagnosis and management of chronic forms of liver disease; tumors of the liver; liver disease primarily of children; special topics; and diseases of the biliary tract. In this new edition hepatitis B and C viruses are treated separately and there are two new chapters on other viral liver diseases. The basic science and clinical aspects of alcoholic liver disease are also now extensively discussed in separate chapters. Diagrams and photographs (both black-and-white and color) are extensively used throughout.
Assessment: This welcome new edition represents a heavyweight in the field of hepatology textbooks. It is comprehensive and compares very favorably with the other North American heavyweight, Schiff's Diseases of the Liver, 9th edition, by Schiff et al. (Lippincott Williams & Wilkins, 2003), as well as the British stalwart, Sherlock and Dooley's Diseases of the Liver and Biliary System, 11th edition (Blackwell Publishing, 2002). It should be available in every gastroenterologist's office as well as in reference sections in medical school libraries.
Daniel R. Ganger
This third edition of an encyclopedic textbook of liver diseases appears six years after the last edition, with multiple authors under the guidance of the same editors. The purpose is to present thorough and balanced reviews of the pathophysiology of liver diseases. The book meets these worthy objectives, and this new edition was due. It is intended for students of liver diseases: hepatologists, gastroenterologists, surgeons, and internists. The authors and editors are respected teachers, investigators, and clinicians in the specialty. This two-volume book is divided into 68 chapters in a reasonable format that allows the reader to rapidly find the issue of interest. The illustrations are of excellent quality and very pertinent. The references are current to 1995. This is now the most important textbook of hepatology. It reflects the major advances of the specialty and is an obligatory reference for all students of liver diseases. This third edition was badly needed. With its revised chapters, it is a significant contribution that maintains the excellent quality of previous editions.
From The Critics
Intent on making the burgeoning knowledge in the field manageable to practicing clinicians as well as students, the editors have assembled 61 essays which distill data from numerous primary references and provide current information on every facet of liver disease. The first section covers the anatomy, physiology, and biochemistry of liver function, as well as the porphyrias, hepatic fibrosis and cirrhosis. Subsequent sections cover systemic effects of liver disease, laboratory methods for evaluating liver disease, toxic injury and associated diseases, diagnosis of liver disease due to infectious agents, chronic forms of liver disease, tumors, pediatric liver disease, and diseases of the biliary tract. Zakim is a professor of medicine emeritus at Cornell University Medical College; Boyer is John J. Lee Professor of Medicine and Director of the Liver Research Institute at the University of Arizona. With a few exceptions (Europe, Japan, Hong Kong), contributors are from U.S. medical universities and institutes. Annotation c. Book News, Inc., Portland, OR

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780721690513
  • Publisher: Elsevier Health Sciences
  • Publication date: 8/5/2002
  • Edition description: REV
  • Edition number: 4
  • Pages: 1952
  • Product dimensions: 8.55 (w) x 11.25 (h) x 3.74 (d)

Table of Contents


Section I. Cell Biology, Biochemistry, and Physiology of Liver Function
1. Cell Biology and Anatomy of the Liver
2. Hepatic Regeneration
3. Hepatic Metabolism of Glucose and Fatty Acids
4. Amino Acid Metabolism and Synthesis of Urea
5. Liver Disease, Alcohol, and Lipoprotein Metabolism
6. Hepatic Metabolism of Vitamin A
7. Vitamin D Metabolism and Metabolic Bone Disease
8. Metabolism of Xenobiotics by Human Liver
9. Bilirubin Metabolism and Its Disorders
10. Mechanisms of Secretion of Bile
11. The Porphyrias
12. Fibrosis: Representative Molecular Elements, a Basic Concept, and Emerging Targets for Suppressive Treatment
13. Mechanisms Stimulating Hepatic Fibrosis
14. Iron Metabolism and Transport

Section II. Systemic Effects of Liver Disease Section
15. Clinical Features of Hepatic Encephalopathy
16. Fulminant Hepatic Failure
17. Renal Function in Cirrhosis: Pathophysiology and Clinical Features
18. Cardiovascular and Pulmonary Complications in Patients with Liver Disease
19. The Liver and Hematopoiesis
20. Hemostasis
21. Portal Hypertension and Bleeding Esophageal Varices
22. Diagnosis and Management of Ascites in the Cirrhotic Patient

Section III. Laboratory Methods for Evaluation of Patients with Liver Disease
23. Laboratory Evaluation of the Patient with Liver Disease
24. Laparoscopy in Liver Disease
25. Histopathologic Diagnosis of Liver Disease


Section IVa. Toxic Injury to the Liver and Associated Diseases
26. Mechanisms of Chemically-Induced Liver Disease
27. Drug-Induced Liver Disease and Environmental Toxins
28. Pre- and Post-operative Hepatic Dysfunction
29. Mechanisms of Alcohol-Induced Liver Disease
30. Clinical Features and Management of Alcoholic Liver Disease and Nonalcoholic Steatohepatitis

Section IVb. Diagnosis and Management of Liver Disease Due to Infectious Agents
31. Hepatitis A and E
32. Hepatitis B
33. Hepatitis C
34. Other Hepatitis Viruses
35. Parasitic Diseases of the Liver
36. Bacterial and Miscellaneous Infections of the Liver

Section IVc. Diagnosis and Management of Chronic Forms of Liver Disease
37. Immune Mechanisms in the Production of Liver Disease
38. Autoimmune Liver Disease
39. Primary Biliary Cirrhosis
40. Hepatobiliary Complications of Ulcerative Colitis
41. Wilson's Disease
42. Hemochromatosis
43. Granulomatous Disease of the Liver

Section IVd. Tumors of the Liver
44. Molecular Pathogenesis of Hepatocellular Carcinoma
45. Tumors of the Liver
46. Surgical Therapy of Hepatic Tumors

Section IVe. Liver Disease Primarily of Children
47. Alpha1-Antitrypsin Deficiency
48. Inborn Errors of Metabolism Causing Permanent Hepatic Injury
49. Cystic Diseases of the Liver
50. Cholestatic Syndromes of Infancy and Childhood

Section IVf. Special Topics
51. HIV-Associated Hepatobiliary Disease
52. The Liver in Systemic Illness
53. Budd-Chiari Syndrome
54. The Liver in Pregnancy
55. Liver Transplantation
56. Recurrent Disease Following Liver Transplantation
57. Liver Disease in Patients Receiving Total Parenteral Nutrition
58. Liver Disease Following Bone Marrow Transplantation

Section IVg. Diseases of the Biliary Tract
59. Pathogenesis and Dissolution of Gall Stones
60. The Medical Management of Gall Stones
61. Non-Surgical Management of Biliary Tract Diseases

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