Hereditary Cancer: Second International Research Conference on Familial Cancer / Edition 1

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Overview

This book provides an update of the latest advances by international experts in the field of hereditary cancer, with special emphasis on the needs of medical practice. The first part is devoted to a discussion of the mechanisms by which predispositions lead to breast and ovarian cancer, intestinal cancer, neoplasia of endocrine glands, and tumors in rare cancer syndromes. Attention is also given to epidemiological aspects of familial cancer occurrence. The second part covers genetic counseling and testing of members of high-risk families, as well as the prevention and treatment of hereditary cancer. Clearly written and well-organized, this book provides essential information not only for molecular geneticists and epidemiologists, but also for genetic counselors and oncologists.
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Product Details

  • ISBN-13: 9783805563291
  • Publisher: Karger, S. Inc.
  • Publication date: 1/1/1996
  • Edition number: 1
  • Pages: 225

Table of Contents

Preface
Acknowledgements
Sponsors of the Conference and the Proceedings
Identification of BRCA1 Gene Carriers by Genetic Linkage Analysis 2
A Protein Truncation Test for BRCA1 6
Histoprognostic Grade in Hereditary Breast Cancer: Is Inheritance Linked to BRCA1 a Bad Prognostic Factor? 11
Indication for a Possible Third Breast Cancer Predisposing Gene, BRCA3, in the Chromosome 8p12-p22 Region 19
The Potential Role of Common Polymorphisms in Predisposition to Breast and Ovarian Cancer 27
Genotype-Phenotype Correlations in Intestinal Carcinogenesis: Lessons from Mouse Models 35
Familial Gastric Cancer in Hawaii Japanese: Environmental and Genetic Interactions 46
Mutations in the APC Gene and the Related Phenotypes of Swiss Patients with Familial Adenomatous Polyposis 52
APC Mutations in German Families with Polyposis coli: Phenotype-Genotype Relationships 59
Molecular Studies in Hereditary Nonpolyposis Colorectal Cancer: Microsatellite Instability and Germline Mutations 67
Genetic Testing Redefines Hereditary Nonpolyposis Colon Cancer 74
Epidemiology of Colorectal Cancer: Questions Answered and Questions Remaining 84
[actual symbol not reproducible] Mice Develop Ulcerative Colitis and Adenocarcinoma of the Colon 93
Genetic Changes Associated with Multiple Endocrine Neoplasia Type 2A 99
Additional Endocrinopathies in a Large Family with Familial Medullary Thyroid Carcinoma: Implications for Treatment and Follow-Up 102
Analysis of RET Proto-Oncogene Mutations in Swiss Families with Multiple Endocrine Neoplasia Type 2 108
Mutations in the RET Proto-Oncogene in German Families with Multiple Endocrine Neoplasia Type 2 119
Germline Mutations in the VHL Tumor Suppressor Gene in Patient with von Hippel-Lindau Disease: Correlation with Phenotypes and Presymptomatic Diagnosis 122
VHL Disease with Pheochromocytoma in the Black Forest Is Caused by a [actual symbol not reproducible] Change at Nucleotide 505 (Tyr98His) of the VHL Gene which Was Introduced by a Common Ancestor 126
Additional Involvements of Nucleotide Excision Repair Enzymes: Key to Understanding the Symptoms of Inherited Repair Deficiency? 129
Crosslinker-Induced p53-Independent Apoptosis in Fanconi Anaemia Lymphoblastoid Cell Lines 136
Fanconi Anaemia in Europe 141
The Involvement of Programmed Cell Death in the Phenotypic Expression of Ataxia telangiectasia 146
DNA Methylation and Inactivation of Tumor Suppressor Genes 152
Genetic Counselling of Cancer Patients and Their Relatives 162
Clinical Applications of Genetic Studies in Hereditary Colorectal Cancer 173
Presymptomatic DNA Testing in Families with Multiple Endocrine Neoplasia Type 2A: Practical Counseling Issues 191
Psychological Intervention and Consultation Process in Predictive Genetics in Oncology: Research and Clinical Issues 196
Chemoprevention of Breast Cancer 200
Chemoprevention in Familial Colorectal Cancer 206
Familial Cancer - Radiotherapeutic Aspects 211
Hepatitis B Virus Infection: Molecular Therapy and Prevention 216
Subject Index 229
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