Hereditary Cancer: Second International Research Conference on Familial Cancer / Edition 1

Hereditary Cancer: Second International Research Conference on Familial Cancer / Edition 1

by Hj Muller, R. J. (Ed.) Scott, W. (Ed.) Weber
     
 

ISBN-10: 3805563299

ISBN-13: 9783805563291

Pub. Date: 01/01/1996

Publisher: Karger, S. Inc.

This book provides an update of the latest advances by international experts in the field of hereditary cancer, with special emphasis on the needs of medical practice. The first part is devoted to a discussion of the mechanisms by which predispositions lead to breast and ovarian cancer, intestinal cancer, neoplasia of endocrine glands, and tumors in rare cancer…  See more details below

Overview

This book provides an update of the latest advances by international experts in the field of hereditary cancer, with special emphasis on the needs of medical practice. The first part is devoted to a discussion of the mechanisms by which predispositions lead to breast and ovarian cancer, intestinal cancer, neoplasia of endocrine glands, and tumors in rare cancer syndromes. Attention is also given to epidemiological aspects of familial cancer occurrence. The second part covers genetic counseling and testing of members of high-risk families, as well as the prevention and treatment of hereditary cancer. Clearly written and well-organized, this book provides essential information not only for molecular geneticists and epidemiologists, but also for genetic counselors and oncologists.

Product Details

ISBN-13:
9783805563291
Publisher:
Karger, S. Inc.
Publication date:
01/01/1996
Pages:
225

Table of Contents

Preface
Acknowledgements
Sponsors of the Conference and the Proceedings
Identification of BRCA1 Gene Carriers by Genetic Linkage Analysis2
A Protein Truncation Test for BRCA16
Histoprognostic Grade in Hereditary Breast Cancer: Is Inheritance Linked to BRCA1 a Bad Prognostic Factor?11
Indication for a Possible Third Breast Cancer Predisposing Gene, BRCA3, in the Chromosome 8p12-p22 Region19
The Potential Role of Common Polymorphisms in Predisposition to Breast and Ovarian Cancer27
Genotype-Phenotype Correlations in Intestinal Carcinogenesis: Lessons from Mouse Models35
Familial Gastric Cancer in Hawaii Japanese: Environmental and Genetic Interactions46
Mutations in the APC Gene and the Related Phenotypes of Swiss Patients with Familial Adenomatous Polyposis52
APC Mutations in German Families with Polyposis coli: Phenotype-Genotype Relationships59
Molecular Studies in Hereditary Nonpolyposis Colorectal Cancer: Microsatellite Instability and Germline Mutations67
Genetic Testing Redefines Hereditary Nonpolyposis Colon Cancer74
Epidemiology of Colorectal Cancer: Questions Answered and Questions Remaining84
[actual symbol not reproducible] Mice Develop Ulcerative Colitis and Adenocarcinoma of the Colon93
Genetic Changes Associated with Multiple Endocrine Neoplasia Type 2A99
Additional Endocrinopathies in a Large Family with Familial Medullary Thyroid Carcinoma: Implications for Treatment and Follow-Up102
Analysis of RET Proto-Oncogene Mutations in Swiss Families with Multiple Endocrine Neoplasia Type 2108
Mutations in the RET Proto-Oncogene in German Families with Multiple Endocrine Neoplasia Type 2119
Germline Mutations in the VHL Tumor Suppressor Gene in Patient with von Hippel-Lindau Disease: Correlation with Phenotypes and Presymptomatic Diagnosis122
VHL Disease with Pheochromocytoma in the Black Forest Is Caused by a [actual symbol not reproducible] Change at Nucleotide 505 (Tyr98His) of the VHL Gene which Was Introduced by a Common Ancestor126
Additional Involvements of Nucleotide Excision Repair Enzymes: Key to Understanding the Symptoms of Inherited Repair Deficiency?129
Crosslinker-Induced p53-Independent Apoptosis in Fanconi Anaemia Lymphoblastoid Cell Lines136
Fanconi Anaemia in Europe141
The Involvement of Programmed Cell Death in the Phenotypic Expression of Ataxia telangiectasia146
DNA Methylation and Inactivation of Tumor Suppressor Genes152
Genetic Counselling of Cancer Patients and Their Relatives162
Clinical Applications of Genetic Studies in Hereditary Colorectal Cancer173
Presymptomatic DNA Testing in Families with Multiple Endocrine Neoplasia Type 2A: Practical Counseling Issues191
Psychological Intervention and Consultation Process in Predictive Genetics in Oncology: Research and Clinical Issues196
Chemoprevention of Breast Cancer200
Chemoprevention in Familial Colorectal Cancer206
Familial Cancer - Radiotherapeutic Aspects211
Hepatitis B Virus Infection: Molecular Therapy and Prevention216
Subject Index229

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