Hereditary Colorectal Cancer / Edition 1

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Early detection of colorectal cancers is a significant and relatively recent achievement. Persons who carry genetic mutations linked to hereditary colorectal cancer make up 20% of the patient population. With the advent of molecular genetics and the description of hereditary colorectal cancer syndromes, clinicians and genetic counselors are able to use genetic predisposition testing as an effective and important way to identify patients and families affected by inherited colorectal cancer syndromes. Hereditary Colorectal Cancer is a comprehensive collection that documents not only Familial Adenomatous Polyposis and the Lynch syndrome, but also less understood syndromes, including the Hamartomatous Polyposis Syndromes and MutYH Associated Polyposis. Internationally recognized clinicians and researchers further delve into the evolution and potential of syndromes, genes and molecular alterations that have yet to be defined. Instrumental experts in this field of discovery were carefully selected by the section editors to create this premier reference work for clinicians, scientists and researchers confronted with the treatment and management of hereditary colorectal cancer.

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Editorial Reviews

Doody's Review Service
Reviewer: Neal W Wilkinson, MD (Kalispell Regional Medical Center)
Description: This comprehensive book details basic scientific knowledge, clinically relevant algorithms, and the historical framework of hereditary colorectal cancer. This is the only book of this depth on this topic, to my knowledge.
Purpose: The authors set out to provide a single source of information on hereditary colorectal cancer. Like any edited book, there is some variability between chapters.
Audience: It is written for colorectal specialists, which may include surgeons, gastroenterologists, oncologists, and geneticists. The abundant chapters on the basic science behind recent developments might be of interest to the research community. The book would be an excellent definitive reference for any medical library. The depth and scope of this book would be beyond the needs of general surgeons or surgical residents.
Features: The book is quite expansive in its coverage of the early history and development of our understanding of genetic colorectal diseases. The scientific section is rather large and the genetics section has very detailed descriptions of a variety of topics. Other, more clinically relevant sections cover familial adenomatous polyposis (FAP) and hereditary non-polyposis colorectal cancer (HNPCC) as well as a variety of other polyp conditions; these sections contain numerous chapters and present a complete and detailed overview. The book also includes a review of genetic counseling around the globe.
Assessment: This is a high quality book that delivers specific and detailed information on hereditary colorectal cancer. There is no comparable book, and the information it provides would be very difficult to obtain from other sources in such a well-balanced and complete presentation.
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Product Details

  • ISBN-13: 9781441966025
  • Publisher: Springer US
  • Publication date: 9/13/2010
  • Series: MD Anderson Solid Tumor Oncology Series, #5
  • Edition description: 2010
  • Edition number: 1
  • Pages: 630
  • Product dimensions: 6.30 (w) x 9.30 (h) x 1.70 (d)

Table of Contents

Part I History

1 History: Familial Adenomatous Polyposis Susan K. Clark Kay F. Neale Robin K.S. Phillips 3

2 Historical Aspects of Lynch Syndrome Henry T. Lynch Megan P. Hitchins Trudy G. Shaw Jane F. Lynch Hemant Roy 15

Part II Basic Sciences and Genetics

3 Molecular Genetics of Familial Adenomatous Polyposis Luis G. Carvajal-Carmona Andrew Silver Ian P. Tomlinson 45

4 DNA Mismatch Repair C. Richard Boland 67

5 Basic Sciences and Genetics: Hamartomatous Polyposis James R. Howe Daniel Calva 87

6 Hyperplastic Polyposis Syndrome: Colorectal Cancer Predisposition Joanne Young 111

7 MUTYH-Associated Polyposis Jeremy P. Cheadle 133

8 Polymorphic Variation and Risk of Colorectal Cancer Richard A. Hubner Richard S. Houlston 147

Part III Pathology

9 The Pathologist and the Phenotype of Hereditary Colorectal Cancer Jeremy R. Jass 175

Part IV Clinical Science: Familial Adenomatous Polyposis

10 Genotype Phenotype Correlation in Familial Adenomatous Polyposis Miguel A. Rodriguez-Bigas 197

11 Surgery for Familial Adenomatous Polyposis James Church 203

12 Duodenal Adenomas in Familial Adenomatous Polyposis Andrew Latchford Brian Saunders 219

13 FAP-Associated Desmoid Tumours Gabriela Moeslein 239

14 Attenuated Familial Adenomatous Polyposis: Diagnosis, Management, and Future Prognosis Thérèse M.F. Tuohy Randall W. Burt 253

Part V Clinical Science: Hereditary Nonpolyposis Colorectal Cancer

15 An Overview of the Lynch Syndrome (Hereditary Non-polyposis Colorectal Cancer) Hans F.A. Vasen J.C.H. Hardwick 271

16 Surgical Management in Lynch Syndrome Raul Cutait Miguel A. Rodriguez-Bigas 301

17 Extracolonic Tumors Benedito Mauro Rossi Fabio de Oliveira Ferreira 311

18 Surveillance Heikki J. Järvinen Jukka-Pekka Mecklin 335

Part VI Clinical Science: MYH Associated Polyposis

19 MUTYH-Associated Polyposis N. Jones M. Nielsen S. Vogt C.M. Tops H.F.A. Vasen F.J. Hes S. Aretz J.R. Sampson 349

Part VII Clinical Science: Hamartomatous Polyposis

20 Peutz-Jeghers Syndrome Francis M. Giardiello 365

21 Clinical Aspects of Juvenile Polyposis Daniel Calva James R. Howe 375

22 Hereditary Mixed Polyposis Syndrome and Multiple Adenoma Patients Huw Thomas 401

Part VIII Clinical Science: Hyperplastics Polyposis

23 Hyperplastic Polyposis Angel Ferrández Randall W. Burt 411

Part IX Genetic Counseling

24 Genetic Counseling Overview Terri Berk 425

25 Across Culture and Health Systems: Europe Marie Luise Bisgaard 431

26 Across Culture and Health Systems: Asia (Hong Kong) Judy Wai-chu Ho Samuel Mun-yin Ho Annie Tsz-wai Chu 445

27 Across Culture and Health Systems: Asia (Japan) Takeo Iwama 461

28 Across Culture and Health Systems: Africa Elize G. Pietersen Brenda Kruger Ursula Algar Raj S. Ramesar 471

29 Across Culture and Health Systems: Argentina Carlos A. Vaccaro 487

30 Genetic Counselling Across Culture and Health Systems: Australia Finlay Macrae Clara Gaff 503

31 Across Culture and Health Systems: Korea Duck-Woo Kim Jae-Gahb Park 535

32 Across Culture and Health Systems: America Thuy M. Vu 545

Part X Psychosocial Aspects of Hereditary Colorectal Cancer

33 Psychological Impact of Genetic Counseling and Testing for Hereditary Colorectal Cancers Susan K. Peterson 559

Part XI Chemoprevention

34 Chemoprevention for Inherited Colorectal Cancer Patrick M. Lynch 577

Part XII Registries

35 Registries Steffen Bülow Inge Bernstein 595

Index 613

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