Heterocyclic Chemistry / Edition 5

Heterocyclic Chemistry / Edition 5

by John A. Joule, Keith Mills
     
 

This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide.

Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic

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Overview

This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide.

Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry.

The fifth edition ofHeterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry.

Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations:

  • Extensive use of colour to highlight changes in structure and bonding during reactions
  • Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine
  • New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context

Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

PowerPoint slides of all figures from this book, along with the solutions to the exercises, can be found at www.wiley.com/go/joul.

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Product Details

ISBN-13:
9781405193658
Publisher:
Wiley
Publication date:
06/08/2010
Pages:
718
Product dimensions:
7.60(w) x 9.90(h) x 1.60(d)

Table of Contents

Preface
Definitions of abbreviations
1Structures and main physical properties of aromatic heterocycles1
2Reactivity of aromatic heterocycles18
3Synthesis of aromatic heterocycles56
4Typical reactivity of pyridines, quinolines and isoquinolines64
5Pyridines: reactions and synthesis72
6Quinolines and isoquinolines: reactions and synthesis120
7Typical reactivity of pyrylium and benzopyrylium ions, pyrones and benzopyrones146
8Pyryliums, 2- and 4-pyrones: reactions and synthesis148
9Benzopyryliums and benzopyrones: reactions and synthesis166
10Typical reactivity of the diazines: pyridazine, pyrimidine and pyrazine185
11The diazines: pyridazine, pyrimidine and pyrazine: reactions and synthesis189
12Typical reactivity of pyrroles, thiophenes and furans225
13Pyrroles: reactions and synthesis229
14Thiophenes: reactions and synthesis259
15Furans: reactions and synthesis278
16Reactivity of indoles, benzo[b]thiophenes, benzo[b]furans, isoindoles, benzo[c]thiophenes and isobenzofurans301
17Indoles: reactions and synthesis305
18Benzo[b]thiophenes and benzo[b]furans: reactions and synthesis350
19Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions and synthesis360
20Typical reactivity of 1,3- and 1,2-azoles367
211,3-Azoles: imidazoles, thiazoles and oxazoles: reactions and synthesis370
221,2-Azoles: pyrazoles, isothiazoles and isoxazoles: reactions and synthesis394
23Purines: reactions and synthesis409
24Heterocycles containing a ring-junction nitrogen434
25Heterocycles containing more than two hetero atoms447
26Saturated and partially unsaturated heterocyclic compounds: reactions and synthesis463
27Appendix: answers to exercises479
Index485

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