Heterocyclic Chemistry / Edition 5

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Overview

This book has so closely matched the requirements of its readership over the years that it has become the first choice for chemists worldwide.

Heterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, the vast majority of organic work done in the pharmaceutical and agrochemical industries is heterocyclic chemistry.

The fifth edition of Heterocyclic Chemistry maintains the principal objective of earlier editions – to teach the fundamentals of heterocyclic reactivity and synthesis in a way that is understandable to second- and third-year undergraduate chemistry students. The inclusion of more advanced and current material also makes the book a valuable reference text for postgraduate taught courses, postgraduate researchers, and chemists at all levels working with heterocyclic compounds in industry.

Fully updated and expanded to reflect important 21st century advances, the fifth edition of this classic text includes the following innovations:

  • Extensive use of colour to highlight changes in structure and bonding during reactions
  • Entirely new chapters on organometallic heterocyclic chemistry, heterocyclic natural products, especially in biochemical processes, and heterocycles in medicine
  • New sections focusing on heterocyclic fluorine compounds, isotopically labeled heterocycles, and solid-phase chemistry, microwave heating and flow reactors in the heterocyclic context

Essential teaching material in the early chapters is followed by short chapters throughout the text which capture the essence of heterocyclic reactivity in concise resumés suitable as introductions or summaries, for example for examination preparation. Detailed, systematic discussions cover the reactivity and synthesis of all the important heterocyclic systems. Original references and references to reviews are given throughout the text, vital for postgraduate teaching and for research scientists. Problems, divided into straightforward revision exercises, and more challenging questions (with solutions available online), help the reader to understand and apply the principles of heterocyclic reactivity and synthesis.

"...new coverage of Heterocyclic aspects of combinatorial chemistry, biprocessing & conducting polymers. This 4th edition gives graduat students & professionals up-dated information on this complex subject."

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Editorial Reviews

From the Publisher

“Overall, this book is recommended as a text for undergraduate and more advanced students on this pervasive, important, and underappreciated topic in chemistry.” (Journal of Chemical Education, 1 October 2012)

"The work seems most valuable as a resource for researchers in the area, especially the detailed discussions that classify specific reactions . . . recommended. Chemistry collections serving upper-division undergraduates and above." (Choice, 1 February 2011)

"The fifth edition is a high-quality book, which represents a very valuable and concise source of information about heterocyclic chemistry. In the covered topics the book provides as a textbook a new gold standard... Due to the modern aspects it will be a compulsory reading for synthetically oriented chemists working in the field of heterocyclic chemistry." (Synthesis, February 2011)

"This excellent book is well written, heavily referenced, and thoroughly indexed. Accordingly, it serves as both an instructional heterocyclic chemistry textbook and a portal to the primary synthetic chemistry literature." (Journal of Medicinal Chemistry, 2011)

"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that ‘With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real ‘coup de grace'." (Reviews, December 2010)

“My recommendation is, even if you already have the 4th edition, to buy the latest version. At only £39.95 for the paperback version this is outstanding value for money.” (Organic Process Research & Development Journal, 2010)

"My favourite chapter is the organometallic chemistry that presents an up-to-date treatment of the topic and helps confirms a colleague's observation that ‘With today's techniques one can be convinced that a modern organic chemist can make any small molecule he or she desires.' I particularly like the treatment of the concatenation of five-membered ring systems, an increasingly important area in medicinal chemistry. This chapter proves a real ‘coup de grace'." (Reviews, December 2010)

Booknews
A textbook for a course for students in the second or third year of undergraduate chemistry study, but more advanced material suitable for graduates is also included. Joule (chemistry, U. of Manchester) and Mills, a scientist in the private sector, introduce the fundamentals of hetercyclic reactivity and synthesis. They provide answers to the exercises. The fourth edition incorporates new findings; the earlier ones appeared between 1972 and 1995. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9781405193658
  • Publisher: Wiley
  • Publication date: 6/8/2010
  • Edition number: 5
  • Pages: 718
  • Sales rank: 1,086,649
  • Product dimensions: 7.60 (w) x 9.90 (h) x 1.60 (d)

Meet the Author

John Joule is Emeritus Professor in the School of Chemistry, The University of Manchester, UK

Keith Mills spent 25 years in the Medicinal Chemistry and Development Chemistry departments at GlaxoSmithKline, Stevenage, UK, and is now an independent consultant.

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Table of Contents

Preface

Definitions of abbreviations

1. Heterocyclic nomenclature

2. Structures and spectroscopic properties of aromatic heterocycles

3. Substitutions of aromatic heterocycles

4. Organometallic heterocyclic chemistry

5. Methods in heterocyclic chemistry

6. Ring synthesis of aromatic heterocycles

7. Typical reactivity of pyridines, quinolines and isoquinolines

8. Pyridines: reactions and synthesis

9. Quinolines and isoquinolines: reactions and synthesis

10. Typical reactivity of pyrylium and benzopyrylium ions, pyrones and benzopyrones

11. Pyryliums, 2- and 4-pyrones: reactions and synthesis

12. Benzopyryliums, benzopyrones: reactions and synthesis

13. Typical reactivity of the diazines: pyridazine, pyrimidine and pyrazine

14. The diazines: pyridazine, pyrimidine, and pyrazine: reactions and synthesis

15. Typical reactivity of pyrroles, thiophenes, and furans

16. Pyrroles: reactions and synthesis

17. Thiophenes: reactions and synthesis

18. Furans: reactions and synthesis

19. Typical reactivity of indoles, benzo[b]thiophenes, benzo[b]furans, isoindoles, benzo[c]thiophenes and isobenzofurans

20. Indoles: reactions and synthesis

21. Benzo[b]thiophenes and benzo[b]furans: reactions and synthesis

22. Isoindoles, benzo[c]thiophenes and isobenzofurans: reactions and synthesis

23. Typical reactivity of 1,3- and 1,2-azoles and benzo-1,3- and -1,2-azoles

24. 1,3-Azoles: imidazoles, thiazoles, and oxazoles: reactions and synthesis

25. 1,2-Azoles: pyrazoles, isothiazoles, isoxazoles: reactions and synthesis

26. Benzanellated azoles: reactions and synthesis

27. Purines: reactions and synthesis

28. Heterocycles containing a ring-junction nitrogen (bridgehead compounds)

29. Heterocycles containing more than two heteroatoms

30. Saturated and partially unsaturated heterocyclic compounds: reactions and synthesis

31. Special topics

32. Heterocycles in biochemistry; heterocyclic natural products

33. Heterocycles in medicine

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