Hierarchical Genome and Differentiation Waves: Novel Unification of Development, Genetics and Evolution

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Overview

Richard Gordon is a theoretical biologist and occasional experimentalist with two careers: medical imaging (detection of early breast cancer) and embryology. His avocations are paleontology and the study of diatoms. Because of his interdisciplinary research, he has appointments at the University of Manitoba which include Radiology, Physics, and Electrical & Computer Engineering, with past appointments in Pathology, Botany, and Zoology. With an undergraduate degree in mathematics from the University of Chicago, he then turned to chemical physics for his PhD at the University of Oregon. He won the Rh Institute Award for Outstanding Contrutions to Scholarship and Research in the Interdisciplinary Category in 1981. His eclectic approach to fundamental, outstanding problems in biology and medicine is reflected in his more than 100 published papers and in The Hierarchical Genome.
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What People Are Saying

C. Cristofre Martin
It is rare in science to see an individual challenge the traditional view. Dr Richard Gordon by doing so, shows how the discovery of an unusual wave on the surface of a salamander embryo has radical implications for the unification of the forces of evolution, genetics and development. This book, his magnum opus, is a major achievement in all these disciplines.
C. Cristofre Martin, PhD University of Saskatchewan, Saskatoon, Canada
Gerhard Grossing
Richard Gordon, discover of "differentiation waves" in embryogenesis, has now written an Opus Magnum on the theoretical frontier. The Hierarchical Genome provides a whole new synthesis of development, genetics, and evolution in that it distils the essentials of the logic of evolution in each of the respective domains. Based on the agency of logical, rather than merely physical, differentiation trees on each level, Gordon provides strong support for the idea of a "fractal evolution", which must be seen as a novel and promising alternative to the more constraining options of gradualism or punctuated equilibrium ... The book is strongly recommended for anyone interested in a high-level discussion of the basic principles of evolution.
Gerhard Grössing, PhD Director, Austrian Institute for Nonlinear Studies, Vienna
Graham Dellaire
The Hierarchical Genome cleverly fuses theoretical physics and embryology in a manner that is accessible to the novice physicist and molecular biologist alike. The superb use of historical ancedotes to illustrate the progression of the author's ideas made the book a pleasure to read. As a framework for future experimentation, this work argues convincingly for the use of physical principles in our treatment of developmental genetics.
Graham Dellaire, PhD MRC Human Genetics Unit, Edinburg, UK
Michael A. Goldman
A talented theoretical biologist, Gordon presents a comprehensive, thorough and radically-new look at developmental biology. Even if one does not accept his interpretation of development in terms of cell state splitters and differentiation waves, the book is a fresh, amazing and fascinating summary uniting key fields in biology.
Michael A. Goldman, PhD San Francisco State University
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Product Details

  • ISBN-13: 9789810222680
  • Publisher: Imperial College Press
  • Publication date: 7/28/1999
  • Series: Series in Mathematical Biology and Medicine
  • Edition description: HC_SET
  • Pages: 1980
  • Product dimensions: 6.60 (w) x 8.80 (h) x 4.10 (d)

Table of Contents

Neural Induction and the Organizer
Theory of the Cell State Splitter
Development and Genetics
Development and Evolution
Macroevolution
The Biogenetic Law
The Homeobox
A Cornucopia of Differentiation Waves
Conclusion
Appendices
Bibliography (6943 references)
Glossary
Index
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