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Doody's Review ServiceReviewer: Scott J Weir, PharmD, PhD (University of Kansas Medical Center)
Description: This book describes the evolution and current state of high content screening (HCS).
Purpose: The purpose is to describe the history of HCS; the instrumentation, software applications and sample preparation involved in HCS; markers employed (they refer to reagents); bioinformatics practices and requirements; and examples of applications in cell biology and drug discovery. This book is applicable to current cell biology and drug discovery research. With the availability of siRNA libraries for commercial purchase by universities and industry, this book is very timely.
Audience: It is intended for researchers currently working in HCS or considering HCS as a research tool, whether in academia or industry. The authors, as a rule, are very credible. It is clear that care was taken to select authors who were, or are currently, very active in the field of HCS.
Features: The chapter by Dr Taylor on the history of HCS is very helpful. I particularly liked the sections addressing bioinformatics needs and the application examples. It would be wise, in my opinion, to plan on a second edition perhaps in three years, due to the rapidly changing HCS field.
Assessment: This is one of the better books I have reviewed. As someone who works in drug discovery and early drug development, I found the book very useful.