High Dose Cancer Therapy: Pharmacology, Hematopoietins, Stem Cells / Edition 3

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1999 Hard cover 3rd ed. Illustrated. New. No dust jacket. Sewn binding. Cloth over boards. 976 p. Contains: Illustrations. Periodicals. Audience: General/trade. *****PLEASE ... NOTE: This item is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Editorial Reviews

Doody's Review Service
Reviewer: Jane N. Winter, MD (Northwestern University Feinberg School of Medicine)
Description: This is the third edition of this book on high-dose cancer therapy. A full five years have elapsed since the prior edition, and many advances well-described in this volume have occurred.
Purpose: The focus in this volume is on "high-dose cancer therapy" rather than on "just bone marrow transplantation." This is a difference in orientation. Much of the content expected in a text on "BMT" is in fact included. This is a worthy objective, and the editors are successful in providing a text that complements others that emphasize "transplantation" or attempt to cover all aspects of high-dose treatment including allo- and autotransplantation and multi-cycle intensive therapy.
Audience: The authors state that they target specialists in hematology/oncology from the fellowship to "faculty or practice levels." Certain of the chapters are sufficiently general so as to be accessible to physicians, students and trainees outside the specialty. The editors and contributors are internationally acclaimed experts in their field
Features: The scientific basis, rationale, technical aspects, and clinical applications for high-dose chemotherapy are the subject of this text. Although the orientation is that of the "autotransplanter," allogeneic transplantation (including matched unrelated donor and umbilical cord blood transplants) and immunologically based therapies (such as nonmyeloablative or minitransplants and donor leukocyte infusions for the treatment of relapsed disease) are discussed to some degree. Individual chapters are outstanding whereas others express only a very limited viewpoint, where contributors fail to summarize the work of others in the field. Additional attention to multicycle therapy and a comparison to double and single transplants in the context of a discussion on dose-intensity would seem to be warranted. There are some redundancies that are difficult to avoid in a book such as this. In the supportive care chapters, it would be valuable to distinguish those complications that may be associated with autotransplantation from those that are most commonly associated with allogeneic transplantation; it would be valuable to address the relative frequencies of certain complications in auto- vs. allo- patients. Additional illustrations would improve the attractiveness of the volume.
Assessment: This is a valuable book that will serve both as a reference and as a readable, accessible text for anyone interested in cancer therapy. It complements other texts in the field such as Forman's Bone Marrow Transplantation (Blackwell Publications, 1994) and Atkinson's Clinical Bone Marrow Transplantation: A Reference Textbook (Cambridge University Press, 1994.)
Jane N. Winter
This is the second edition of this volume on high-dose chemotherapy for the treatment of cancer. The first edition was published only three years ago, in 1992. This book is intended as an overview of high-dose cancer therapy (which in most cases entails stem cell rescue with cytokine support) rather than bone marrow transplantation per se. Hence, it successfully complements rather than duplicates other textbooks on stem cell transplantation. This book is intended for hematologists and medical oncologists from fellowship to faculty or practice levels. The editors and chosen authors are leaders in their fields. Some chapters in this book are underillustrated. Some chapters have only a single table. One chapter has no tables or figures. References are appropriate in number and as up-to-date as possible for such a collection. The book is attractive and well-indexed. This volume is rather unique in that it focuses on the use of high-dose therapy with stem cell rescue for the treatment of malignant disease rather than on the concept and applications of bone marrow transplantation. Although it includes both autologous and allogenic transplantation, some important issues such as graft-versus-host disease are not discussed individually but in the context of other topics such as dermatology. On the other hand, high-dose treatment without stem cell rescue, which ordinarily would not be included in a text on bone marrow transplantation, is discussed, as are the various growth factors. Hence, this volume does an excellent job of complementing other existing transplant texts. The new edition is worthy of purchase.
Oncologists, hematologists, surgeons, and other specialists present 52 contributions addressing basic and clinical aspects of high-dose therapy of malignancy. The first section deals with the pharmacologic and biologic principles of high-dose cancer therapy and strategies used. Next is a series of current reviews of the various methods used to reestablish hematopoiesis after high-dose cancer therapy, including allogeneic marrow, autologous marrow, or blood-derived stem cell transplantation, and very high-dose therapy using hematopoietic stem cell transplantation. Data from each of the hematopoietic growth factors now in use are reviewed. The laboratory and clinical support necessary for effective high-dose therapy is then detailed, including the controversial issues of tumor cell detection and marrow purging, followed by a review of the malignancies currently treated with high-dose therapy regimens. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780683306545
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 1/28/2000
  • Edition description: REV
  • Edition number: 3
  • Pages: 951

Table of Contents

Sect. I Strategies for the Use of Agents at High Dose
1 Pharmacologic Strategies for High-Dose Chemotherapy 3
2 Preclinical Models for High-Dose Therapy 14
3 Pharmacokinetics 43
4 Strategies for the Use of Total Body Irradiation as Systemic Therapy in Leukemia and Lymphoma 61
5 Radioimmunoglobulin Therapy 84
6 What Is the Best Strategy for Bone Marrow Transplantation Cancer? 124
7 Analysis of Economic Issues 127
Sect. II Reestablishing Hematopoiesis after Dose-Intensive Therapy
8 The Hematopoietic Microenvironment 143
9 Reconstitution of Hematopoiesis Following Allogeneic Bone Marrow Transplantation 151
10 Autologous Bone Marrow Transplantation 162
11 Reestablishing Hematopoiesis After Dose-Intensive Therapy with Peripheral Stem Cells 182
12 High-Dose Cancer Therapy Without Stem Cell Support - Human Solid Tumors 195
13 Immunologic Reconstitution After High-Dose Chemoradiotherapy and Allogeneic or Autologous Bone Marrow or Peripheral Blood Hematopoietic Stem Cell Transplantation 211
Marrow Contamination
14 Marrow Contamination: Detection and Significance 226
15 Bone Marrow Purging 249
16 Marrow Contamination: Positive Selection 276
Growth Factors
17 Hematopoietic Growth Factors 289
18 Granulocyte-Monocyte Colony-Stimulating Factor 314
19 Delivery of High-Dose Chemotherapy with Recombinant Human Granulocyte Colony-Stimulating Factor Support 333
20 Macrophage Colony-Stimulating Factor: Biology and Clinical Applications 344
21 Interleukin 3: General Biology, Preclinical and Clinical Studies 362
22 Erythropoietin in High-Dose Chemotherapy 385
Sect. III Laboratory and Clinical Support for Dose-Intensive Therapy
23 Nursing for Patients Receiving High-Dose Chemotherapy with Hematopoietic Rescue 405
24 Hickman Line Management 419
25 Blood Bank Support in Patients Undergoing High-Dose Cancer Therapy 437
26 Infectious Diseases 456
27 Pulmonary Complications of Bone Marrow Transplantation 473
28 Hepatic Complications of Bone Marrow Transplantation 487
29 The Cardiovascular System and Anticancer Therapy 505
30 Dermatology 518
31 Genitourinary, Gastrointestinal, and Other Complications 547
32 Gonadal Complications 555
Sect. IV Clinical Applications of High-Dose Therapy
33 High-Dose Therapy for Acute Myelocytic Leukemia 569
34 High-Dose Therapy in Acute Lymphoblastic Leukemia 607
35 Intensive Therapy of Chronic Myelogenous Leukemia 619
36 High-Dose Therapy and Allogeneic Bone Marrow Transplantation in Chronic Lymphocytic Leukemia 626
37 High-Dose Therapy, Autologous Stem Cells, and Hematopoietic Growth Factors for the Management of Multiple Myeloma 638
38 Autologous Bone Marrow Transplantation for Hodgkin's Disease 651
39 High-Dose Therapy for the Treatment of Non-Hodgkin's Lymphoma 662
40 High-Dose Therapy in Burkitt's Lymphoma 677
41 High-Dose Chemotherapy in the Management of Malignant Germ Cell Tumors 690
42 Dose-Intensive Therapy in Breast Cancer 701
43 High-Dose Chemotherapy with Autologous Bone Marrow Support for Lung Cancer 719
44 High-Dose Chemotherapy and Autologous Marrow Transplantation for Common Epithelial Ovarian Cancer 729
45 Myeloablative Treatment Supported by Marrow Infusions for Children with Neuroblastoma 735
46 Dose-Intensive Therapy for Advanced Melanoma 750
47 High-Dose Therapy for Brain Tumors: Rationale, Results, and Revelations 755
48 Autologous Bone Marrow Transplantation for Miscellaneous Tumors 763
Index 773
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