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Doody's Review ServiceReviewer: Jane N. Winter, MD (Northwestern University Feinberg School of Medicine)
Description: This is the second edition of this volume on high-dose chemotherapy for the treatment of cancer. The first edition was published only three years ago, in 1992.
Purpose: This book is intended as an overview of high-dose cancer therapy (which in most cases entails stem cell rescue with cytokine support) rather than bone marrow transplantation per se. Hence, it successfully complements rather than duplicates other textbooks on stem cell transplantation.
Audience: This book is intended for "hematologists and medical oncologists from fellowship to faculty or practice levels." The editors and chosen authors are leaders in their fields.
Features: Some chapters in this book are underillustrated. Some chapters have only a single table. One chapter has no tables or figures. References are appropriate in number and as up-to-date as possible for such a collection. The book is attractive and well-indexed.
Assessment: This volume is rather unique in that it focuses on the use of high-dose therapy with stem cell rescue for the treatment of malignant disease rather than on the concept and applications of bone marrow transplantation. Although it includes both autologous and allogenic transplantation, some important issues such as graft-versus-host disease are not discussed individually but in the context of other topics such as dermatology. On the other hand, high-dose treatment without stem cell rescue, which ordinarily would not be included in a text on bone marrow transplantation, is discussed, as are the various growth factors. Hence, this volume does an excellent job of complementing other existing transplant texts. The new edition is worthy of purchase.