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High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies

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High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques.

The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates.

Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff.

· Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies
· Thorough literature review and summary of published information
· Detailed discussion and examples of the method development process

Audience: Researchers in pharmaceutical drug development, drug analysis and related clinical chemistry disciplines for therapeutic drug monitoring, and forensic scientists who perform bioanalytical sample preparation.

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Editorial Reviews

From the Publisher
"Wells uses his experience as an educator in the field to great effect: the introductory chapter on solid-phase ectraction is one of the most useful overall introductions to this technique available to date... for a book on a topic as complex as this one, High-Throughput Bioanalytical Sample Preparation: Methods and Automaton Strategies" is surprisingly enjoyable to read... this book represents a valuable point of reference, both for types of hardware and accessories available and their vendors, and for further literature on the subject, which is suggested for each chapter in extensive and thorough reviews of the current literature."

Dr. Mark Jairaj, LCGC Europe, February 2004

" High Throughout Bioanalytical Sample Preparation is a well written and convenient monograph for anyone involved in sample preparation method development, and gives the reader information that will be useful in daily laboratory work. This book is helpful in the first steps of planning sample throughput for bioanalysis in the field of pharmaceutical drug development."

Hiroyuki Kataoka, School of Pharmacy, Shujitsu University, Japan, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2005

"It certainly represents a valuable addition to the literature on sample preparation for bioanalysis and should be read by both experts and beginners in the field."

I.D. Wilson, CHROMATOGRAPHIA, Vol. 61, No. 5/6, 2005

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Product Details

Table of Contents

Chapter 1. Role of Bioanalysis in Pharmaceutical Drug Development
Chapter 2. Fundamental Strategies for Bioanalytical Sample Preparation
Chapter 3. High Throughput Tools for Bioanalysis: Microplates
Chapter 4. High Throughput Tools for Bioanalysis: Accessory Products
Chapter 5. Automation Tools and Strategies for Bioanalysis
Chapter 6. Protein Precipitation: High Throughput Techniques and Strategies for Method Development
Chapter 7. Protein Precipitation: Automation Strategies
Chapter 8. Liquid-Liquid Extraction: High Throughput Techniques
Chapter 9. Liquid-Liquid Extraction: Strategies for Method Development and Optimization
Chapter 10. Liquid-Liquid Extraction: Automation Strategies
Chapter 11. Solid-Phase Extraction: High Throughput Techniques
Chapter 12. Solid-Phase Extraction: Strategies for Method Development and Optimization
Chapter 13. Solid-Phase Extraction: Automation Strategies
Chapter 14. On-Line Sample Preparation: High Throughput Techniques and Strategies for Method Development
Chapter 15. Advances in Sample Preparation for Bioanalysis

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