High-Yield Immunology / Edition 2

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This book extracts the most important information on immunology and presents it in a concise, uncluttered fashion to prepare students for USMLE. High-Yield™ means exactly that!

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Product Details

  • ISBN-13: 9780781774697
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 8/28/2005
  • Series: High-Yield Series
  • Edition description: Second
  • Edition number: 2
  • Pages: 112
  • Sales rank: 1,005,365
  • Product dimensions: 7.10 (w) x 9.98 (h) x 0.31 (d)

Table of Contents

Preface vii
Acknowledgments viii
1 Overview 1
I Synopsis 1
II Concerns in Medicine 1
III Host-Parasite Equilibrium 1
IV Development of the Acquired Immune System 2
V Clonal Selection Theory 4
2 Antigens 5
I Definitions 5
II Factors Determining Antigenicity 5
III Examples of Antigens 5
3 Innate Immunity 7
I Fundamental Characteristics 7
II Defensive Mechanisms 7
III Acute Phase Response (APR) 10
IV Pathogen Recognition Systems 10
4 Antibodies 13
I General Properties 13
II IgG 15
III IgM 17
IV IgA 17
V IgE 19
VI IgD 19
5 Immunogenetics 20
I Genetic Control of Immunoglobulin Chain Synthesis 20
II Genetic Control of Human Leukocyte Antigens (HLAs) 20
III Genetic Control of the T-Cell Antigenic Receptor (TCR) 24
6 Immunologic Assays 26
I Overview 26
II Protection Tests 26
III Agglutination Tests 26
IV Precipitation Reactions 27
V Complement Fixation 29
VI Fluorescent Antibody 31
VII Western Blot 31
VIII Cell Counting and Flow Cytometry 31
IX Reverse Transcription Polymerase Chain Reaction (RT-PCR) 34
X DNA Microarrays 34
7 The Immune Response 35
I Humoral Immunity 35
II Cell-Mediated Immunity (CMI) 39
8 Signal Transduction in Immune Cells 43
I Effective Immune Responses Require Communication Between a Wide Range of Cell Types 43
II Receptor Architecture and Fundamental Characteristics 44
III Signaling Molecules 48
IV Pathways 49
9 Inflammation 53
I Introduction 53
II Inflammation Process 53
III Kinetics 55
IV Mediators of Inflammation 55
10 Hypersensitivity Diseases 59
I Overview 59
II Anaphylaxis (Type I) Reactions 59
III Cell Surface Antigen-Antibody (Ag-Ab) Cytotoxicity (Type II) Reactions 62
IV Antigen-Antibody (Ag-Ab) Complex (Type III) Reactions 63
V Delayed-Type Hypersensitivity (Type IV) Reactions 65
11 Immunodeficiency Diseases 66
I Overview 66
II Developmental Immunodeficiency Disorders 66
III Acquired Immunodeficiency Syndrome (AIDS) 68
IV Cytokine and Chemokine Deficiencies 70
V Senescence (Aging) of the Immune Response 70
12 Autoimmune Disorders 71
I Overview 71
II Immunoregulation Breakdown 71
III Systemic Autoimmune Disorders 72
IV Organ-Specific Autoimmune Disorders 73
13 Immunologic Aspects of Transplantation 76
I Histocompatibility 76
II Complications of Organ Transplantation 77
III Immunosuppression 78
14 Cancer Immunology 80
I Definition 80
II Oncogenes 80
III Cancer and the Immune System 80
IV Cancer Immunotherapy 81
15 Immunization 83
I Overview 83
II Specific Vaccines 84
III Adjuvants 88
Study Questions and Answers 89
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