Histiocytic Disorders of Children and Adults: Basic Science, Clinical Features and Therapy

by Sheila Weitzman (Editor), R. Maarten Egeler (Editor)

Overview

This comprehensive reference on histiocytic disorders considers the genetics, pathophysiology, and clinical management of this wide range of diseases. It covers all aspects of hystiocytic disorders—from Langerhans cell histiocytosis and hemophagocytic lymphohistiocytosis, to the uncommon cutaneous and extracutaneous histiocytic disorders. Current views on the function of normal histiocytes in the immune system, the pathogenesis, underlying genetic defects, clinical presentation, treatment, controversies in therapy, salvage therapies and the late consequences are also presented.

Product Details

ISBN-13:	9780521184168
Publisher:	Cambridge University Press
Publication date:	02/17/2011
Edition description:	Reissue
Pages:	456
Product dimensions:	6.70(w) x 9.50(h) x 1.00(d)

About the Author

D.O.B 17 April 1945.

D.O.B 6 September 1955.

Table of Contents

Part I. Langerhans Cell Histiocytosis: 1. Introduction to the problem: overview, history, epidemiology and classification Sheila Weitzman and R. Maarten Egeler; 2. The histopathology of Langerhans Cell Histiocytosis Ronald Jaffe; 3. Histiocyte function and the normal immune system Tatjana Nikolic and Pieter Leenen; 4. The immunologic basis of Langerhans Cell Histiocytosis Cristiana Costa, Nicola Annels and R Maarten Egeler; 5. The genetics of Langerhans Cell Histiocytosis Maurizio Arico, S. Scappaticci and Cesare Danesino; 6. Clinical aspects of Langerhans Cell Histiocytosis Jean Donadieu, Jon Pritchard and R. Maarten Egeler; 7. Dermatologic aspects of the Histiocytic disorders Bernice Krafchik, Elena Pope and Scott Walsh; 8. Langerhans Cell Histiocytosis of bone Sheila Weitzman and R. Maarten Egeler; 9. Special aspects of Langerhans Cell Histiocytosis in the adult Maurizio Ariço, Emanuela De Juli, Thierry Genereau and Alan Saven; 10. Adult lung Histiocytosis Tazi Abdellatif, Jeroen Hiltermann and Roberto Vassallo; 11. Central nervous system involvement in Langerhans Cell Histiocytosis Nicole Grois, Helmut Prosch, Daniela Prayer and Hans Lassmann; 12. The treatment of Langerhans Cell Histiocytosis Helmut Gadner and Stephan Ladisch; 13. Novel and salvage therapies in Langerhans Cell Histiocytosis Sheila Weitzman, Kenneth McClain and Robert Arceci; 14. Late effects of Langerhans Cell Histiocytosis and malignancy and LCH Riccardo Haupt, Vasanta Nanduri and R. Maarten Egeler; 15. Uncommon Histiocytic disorders Sheila Weitzman and James Whitlock; Part II. Histiocytic Disorders Involving the Monocyte/Macrophage Pathway: 16. The histopathology of haemophagocytic lymphohistiocytosis Ronald Jaffe; 17. Genetics and pathogenesis of hemophagocytic lymphohistiocytosis Kim Ericson, Bengt Fadeel and Jan-Inge Henter; 18. Clinical aspects and therapy of hemophagocytic lymphohistiocytosis Gritta Janka, Jan-Inge Henter and Shinsaku Imashuku; 19. Macrophage activation syndrome Ronald Laxer, Athimalaipet Ramanan and Rayfel Schneider; 20. Malignant diseases of the mononuclear phagocytic system David Webb and Penelope Brock; 21. Psychosocial aspects of the Histiocytic disorders Steven Simms, Elizabeth Kuh and Giulio D'Angio.

Editorial Reviews

"This is the only current comprehensive text on histiocytic disorders...an essential addition to the libraries of those who are interested in these fascinating diseases."—Doody's Review Service

From the Publisher