A History of Molecular Biology / Edition 1

A History of Molecular Biology / Edition 1

by Michel Morange
     
 

ISBN-10: 0674001699

ISBN-13: 9780674001695

Pub. Date: 03/28/2000

Publisher: Harvard University Press

Every day it seems the media focus on yet another new development in biology—gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology.

A History of Molecular Biology is a complete but compact account for a general readership of

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Overview

Every day it seems the media focus on yet another new development in biology—gene therapy, the human genome project, the creation of new varieties of animals and plants through genetic engineering. These possibilities have all emanated from molecular biology.

A History of Molecular Biology is a complete but compact account for a general readership of the history of this revolution. Michel Morange, himself a molecular biologist, takes us from the turn-of-the-century convergence of molecular biology's two progenitors, genetics and biochemistry, to the perfection of gene splicing and cloning techniques in the 1980s. Drawing on the important work of American, English, and French historians of science, Morange describes the major discoveries—the double helix, messenger RNA, oncogenes, DNA polymerase—but also explains how and why these breakthroughs took place. The book is enlivened by mini-biographies of the founders of molecular biology: Delbrück, Watson and Crick, Monod and Jacob, Nirenberg.

This ambitious history covers the story of the transformation of biology over the last one hundred years; the transformation of disciplines: biochemistry, genetics, embryology, and evolutionary biology; and, finally, the emergence of the biotechnology industry.

An important contribution to the history of science, A History of Molecular Biology will also be valued by general readers for its clear explanations of the theory and practice of molecular biology today. Molecular biologists themselves will find Morange's historical perspective critical to an understanding of what is at stake in current biological research.

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Product Details

ISBN-13:
9780674001695
Publisher:
Harvard University Press
Publication date:
03/28/2000
Edition description:
New Edition
Pages:
348
Product dimensions:
5.98(w) x 9.17(h) x 0.83(d)

Table of Contents

Introduction1
1The Roots of the New Science11
2The One Gene-One Enzyme Hypothesis21
3The Chemical Nature of the Gene30
4The "Phage Group"40
5The Birth of Bacterial Genetics51
6The Crystallization of the Tobacco Mosaic Virus62
7The Role of the Physicists67
8The Influence of the Rockefeller Foundation79
9A New World View88
10The Role of Physics99
11The Discovery of the Double Helix105
12Deciphering the Genetic Code120
13The Discovery of Messenger RNA139
14The French School150
15Normal Science167
16Genetic Engineering184
17Split Genes and Splicing204
18A New Molecular Biology215
19The Discovery of Oncogenes219
20From DNA Polymerase to the Amplification of DNA231
21Molecular Biology in the Life Sciences243
Appendix: Definition of Terms255
Notes259
Acknowledgments323
Index325

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