HIV and the Brain: New Challenges in the Modern Era

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Within the last decade there have been a number of new and important areas of emphasis in HIV care and research, particularly in the context of brain involvement. Without question, clinical and research innovations in the modern era of the HIV pandemic warrant an update on HIV and the brain. Written by a panel of leading experts, HIV and the Brain: New Challenges in the Modern Era offers a clear picture of brain impairment associated with the virus with particular focus on three emerging areas including different genetic strains of the virus throughout the world, interactions between advanced age and HIV, and the impact of HIV on the brain in the context of chronic, long-term treatment with highly active antiretroviral therapy (HAART). HIV and the Brain: New Challenges in the Modern Era provides a comprehensive review of both basic science and clinical implications in these important areas of the disease. The text is of particular relevance to both research scientists and clinicians involved in HIV in the modern era.

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Editorial Reviews

Doody's Review Service
Reviewer: Joseph I Sirven, MD (Mayo Clinic Arizona)
Description: The global picture of HIV infections has changed from a life-threatening disease to a chronic condition requiring long-term medical intervention. With a longer survival rate and advanced age, the possibility of developing brain dysfunction, HIV-associated neurocognitive deficits, and decreased cognitive capacity leading to dementia are major concerns for people infected with HIV. This book describes the impact of the AIDS virus on the brain and its relationship to the introduction of highly active antiretroviral therapy (HAART) in the mid-nineties.
Purpose: The purpose is to evaluate the long-term impact of the AIDS virus on the brain and the effect of aging on the disease process. In addition, current therapies and treatment are outlined as is the need for further research for new treatments for HIV in the aging population. In addition, international studies and research are focusing on the impact of AIDS on quality of life issues around the globe due to the fact that current estimates are that worldwide cases of HIV may be the most common cause of dementia among individuals under the age of 40. The authors successfully provide a broad and insightful literature review of a variety of topics by scientific authorities in the field.
Audience: It is intended for scientists researching AIDS and its impact on the brain, as well as for clinical care providers. This is a great summary and analysis of the changing face of AIDS and HIV-associated cognitive disturbances in the elderly.
Features: The book covers a wide range of issues related to the effect of AIDS on the brain in relation to the aging process and occurrence of decreased cognitive capacity and dementia. The authors provide a broad global view of HIV and the geographic distribution of AIDS worldwide. The chapter on neuroimaging of AIDS patients has colorful and detailed images and graphs that complement the text. A glossary of terms would have been helpful for those readers who do not practice in this discipline.
Assessment: This is a well done literature review of neurological complications associated with HIV in the aging population and current therapies and challenges for those affected with the disease and those who are providing the treatment. The book is useful to those in the field of geriatrics involved with patients with AIDS and accompanying neurological deficits. Clinical care providers and clinical researchers will find the book informative and relevant for treating patients with HIV in the modern era.
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Product Details

  • ISBN-13: 9781603279178
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 2/28/2010

Table of Contents

Chapter 1
Neurocognitive changes in HIV: Evolution of Treatment of HIV Infection.
Erna Milunka Kojic, M.D. Charles Carpenter, M.D.

Chapter 2
Global incidence and epidemiology of the AIDS pandemic, distribution of HIV subtypes and epidemiology of Hepatitis C infection among HIV positive individuals.
Karen T. Tashima, M.D., Aadia Rana, M.D.

Chapter 3
New Insights into HIV Neuropathogenesis.
Tory P. Johnson, M.S., Avindra Nath, M.D.
Chapter 4
Neuropathological findings associated with long term HAART treatment.
Ian. C. Anthony, Ph.D., Jeanne E. Bell, M.D.

Chapter 5
Biomarkers of HIV related Central Nervous System Disease.
Bruce James Brew MBBS MD FRACP, Scott L. Letendre MD

Chapter 6
Neuroimaging Among HIV Infected Patients: Current Knowledge and Future Directions
David F. Tate, Ph.D., Jared Conley, B.S., Dominik Meier, Ph.D., Bradford Navia, M.D., Ph.D., Ronald Cohen, Ph.D., Charles R.G. Guttmann, M.D.

Chapter 7
The assessment of HIV-associated neurocognitive disorders: New challenges in the HAART era
Chronic neuro-AIDS, long-term cognitive assessment, and new risk factors
Lucette A. Cysique, Ph.D., Bruce J. Brew MBBS MD FRACP

Chapter 8
The changing face of HIV-associated cognitive and neuropsychiatric disturbance.
Ron Cohen, Ph.D.

Chapter 9
Youth with HIV/AIDS: Neurobehavioral Consequences
Susannah Allison, Ph.D., Pamela L. Wolters, Ph.D., Pim Brouwers, Ph.D.

Chapter 10
Co-occurrence of HIV, Hepatitis C, and Substance Use Disorders: Effects on Brain Functioning.
Raul Gonzalez, Ph.D., Phillip J. Quartana, Ph.D., Eileen M. Martin, Ph.D.

Chapter 11
The Functional Impact of HIV-associated Neuropsychological Decline
Matthew J. Wright, Ph.D., Ellen Woo, Ph.D., Terry R. Barclay, Ph.D.,
& Charles H. Hinkin, Ph.D.

Chapter 12
Adjunctive therapy for long-term support of cognitive impairment
Joshua T. Dearborn, M.A., Susan E. Maloney, M. A., Nicole Hicklin, M.A.
Elizabeth M. Lane, B.A., Robert Paul, Ph.D.

Chapter 13
HIV-1 Genetic diversity and its biological significance.
Michael M. Thomson, M.D., Ph.D.

Chapter 14
Opportunistic infections in the brain in developing countries
Marcus Tulius T Silva, M.D., M.Sc., Ph.D., Beatriz Grinsztejn, M.D., M.Sc., Ph.D.

Chapter 15
Impact of clade diversity on neuropsychological outcomes
Robert Paul, Ph.D., Ned Sacktor, M.D., Lucette Cysique, Ph.D., Bruce Brew, M.D., Victor Valcour, M.D.

Chapter 16
The effects of aging on HIV disease
Robert C. Kalayjian, M.D., Lena Al-Harthi, Ph.D.

Chapter 17
Neuropsychology of Healthy Aging
Molly E. Zimmerman, Ph.D., Adam M. Brickman, Ph.D.

Chapter 18
Interactions between Advanced Age and HIV Cognitive Impairment
Victor Valcour, M.D., Aaron McMurtray , M.D.

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