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Doody's Review ServiceReviewer: Joseph I Sirven, MD (Mayo Clinic Arizona)
Description: The global picture of HIV infections has changed from a life-threatening disease to a chronic condition requiring long-term medical intervention. With a longer survival rate and advanced age, the possibility of developing brain dysfunction, HIV-associated neurocognitive deficits, and decreased cognitive capacity leading to dementia are major concerns for people infected with HIV. This book describes the impact of the AIDS virus on the brain and its relationship to the introduction of highly active antiretroviral therapy (HAART) in the mid-nineties.
Purpose: The purpose is to evaluate the long-term impact of the AIDS virus on the brain and the effect of aging on the disease process. In addition, current therapies and treatment are outlined as is the need for further research for new treatments for HIV in the aging population. In addition, international studies and research are focusing on the impact of AIDS on quality of life issues around the globe due to the fact that current estimates are that worldwide cases of HIV may be the most common cause of dementia among individuals under the age of 40. The authors successfully provide a broad and insightful literature review of a variety of topics by scientific authorities in the field.
Audience: It is intended for scientists researching AIDS and its impact on the brain, as well as for clinical care providers. This is a great summary and analysis of the changing face of AIDS and HIV-associated cognitive disturbances in the elderly.
Features: The book covers a wide range of issues related to the effect of AIDS on the brain in relation to the aging process and occurrence of decreased cognitive capacity and dementia. The authors provide a broad global view of HIV and the geographic distribution of AIDS worldwide. The chapter on neuroimaging of AIDS patients has colorful and detailed images and graphs that complement the text. A glossary of terms would have been helpful for those readers who do not practice in this discipline.
Assessment: This is a well done literature review of neurological complications associated with HIV in the aging population and current therapies and challenges for those affected with the disease and those who are providing the treatment. The book is useful to those in the field of geriatrics involved with patients with AIDS and accompanying neurological deficits. Clinical care providers and clinical researchers will find the book informative and relevant for treating patients with HIV in the modern era.