HIV: Biochemistry, Molecular Biology, and Drug Discovery / Edition 1 by J. Karn | 9780199634989 | Paperback | Barnes & Noble
HIV: Biochemistry, Molecular Biology, and Drug Discovery / Edition 1

HIV: Biochemistry, Molecular Biology, and Drug Discovery / Edition 1

by J. Karn
     
 

ISBN-10: 019963498X

ISBN-13: 9780199634989

Pub. Date: 02/28/2002

Publisher: Oxford University Press, USA

HIV Volume 2 explores the biochemistry and molecular biology of HIV. Methods for cloning and expressing most of the viral proteins are described as well as assays for studying enzyme function in vitro. It also includes a section on recent approaches to drug discovery.

Contents: The HIV life cycle; Reverse transcriptase; Ribonulease H; Integrase; Protease;

Overview

HIV Volume 2 explores the biochemistry and molecular biology of HIV. Methods for cloning and expressing most of the viral proteins are described as well as assays for studying enzyme function in vitro. It also includes a section on recent approaches to drug discovery.

Contents: The HIV life cycle; Reverse transcriptase; Ribonulease H; Integrase; Protease; Expression of gag, envelope and other HIV antigens using Bacculovirus; Envelope expression and purification; HIV envelope glyocoprotein/CD4 interactions - studies using recombinant vaccinia virus vectors; RNA binding assays for the regulatory proteins tat and rev; Cellular and cell-free assays for tat; Cellular assays for rev; DNA binding proteins interacting with the viral LTR; Nef; Vpu; Vif; Cellular assays for antiviral drugs; Inhibition of HIV by ribozymes and antisense oligonucleotides; Gene therapy approaches to the inhibition of HIV

Product Details

ISBN-13:
9780199634989
Publisher:
Oxford University Press, USA
Publication date:
02/28/2002
Series:
Practical Approach Series, #157
Edition description:
1st ed
Pages:
360
Product dimensions:
6.13(w) x 9.25(h) x 0.75(d)

Table of Contents

Section 1: Biochemistry and molecular biology of viral proteins
1. The HIV life cycle
2. Reverse transcriptase
3. Ribonuclease H
4. Integrase
5. Protease
6. Expression of gag, envelope and other HIV antigens using Bacculovirus
7. Envelope expression and purification
8. HIV envelope expression and purification
9. RNA binding assays for the regulatory proteins tat and rev
10. Cellular and cell-free assays for tat
11. Cellular assays for rev
12. DNA binding proteins interacting with the viral LTR
13. Nef
14. Vpu
15. Vif
Section 2: Drug discovery
16. Cellular assays for antiviral drugs
17. Inhibition of HIV by ribozymes and antisense oligonucleotides
18. Gene therapy approaches to the inhibition of HIV

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >