HIV, Perinatal Infections and Therapy: The Role of the Placenta

HIV, Perinatal Infections and Therapy: The Role of the Placenta

by Richard K. Miller, Henry A. Thiede
     
 

ISBN-10: 1878822454

ISBN-13: 9781878822451

Pub. Date: 06/15/1995

Publisher: Boydell & Brewer, Limited

Proceedings from the 12th Rochester Trophoblast Conference, held in Autumn 1992 in Rochester, New York. The first part of the book addresses the role of the placenta in the transmission of the HIV infection, the central focus of the Conference. Other pre-natal infections, including CMV, Vaccina, Parvovirus, Syphillis, and Herpes Simplex, are then considered, and their…  See more details below

Overview

Proceedings from the 12th Rochester Trophoblast Conference, held in Autumn 1992 in Rochester, New York. The first part of the book addresses the role of the placenta in the transmission of the HIV infection, the central focus of the Conference. Other pre-natal infections, including CMV, Vaccina, Parvovirus, Syphillis, and Herpes Simplex, are then considered, and their implications for perinatal health investigated. The importance of cell regulation is also discussed, exploring the controlling factors which modulate the placental cell membrane and metabolic functions, such as genetic imprinting; the regulation of arachidonic acid cascade; autocrine role for human chorionic gonadotropin; biochemical screening for Down's Syndrome; the role of growth factors and interferon; the autoregulation of gas exchange; and the role of uterine cytokines. HENRY THIEDE is Professor of Obstetrics and Gynecology at the University of Rochester.RICHARD K. MILLERteaches in the University of Rochester Medical Center.

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Product Details

ISBN-13:
9781878822451
Publisher:
Boydell & Brewer, Limited
Publication date:
06/15/1995
Series:
Trophoblast Research, #8
Pages:
632
Product dimensions:
6.69(w) x 10.24(h) x (d)

Table of Contents

Preface
In Memorium - Elizabeth M. Ramsey
Vertical Transmission of HIV: Possible Mechanisms and Placental Responses
Anti-HIV Monoclonal Antibodies Cross-React with Normal Human Trophoblast19
In Vitro Infection of Hofbauer Cells with a Monocyte-Tropic Strain of HIV-1
The HIV-Exposed Placenta Morphologic Observations and Interpretation - A Review47
Maternal-Fetal Transfer and Fetal Toxicity of Anti-HIV Drugs - A Review67
Characterization of Macaque Placental Trophoblast and Hofbauer Cell Response to Zidovudine83
Anti-HIV Therapy and the Placenta Workshop - A Workshop Report97
Hematogenous Infections of the Placenta - An Interdisciplinary and Evolutionary Perspective107
Human Natural Killer Cells Fail to Kill Herpes Simplex Virus Type1-Infected Term Villus Trophoblast Cells137
Vaccinia Virus Infection of Cultured Human First Trimester Trophoblast151
Placenta and Fetal Membrane in Genital Mycoplasmic Infection: Immunofluorescence and Electron Microscopic Study161
The Value of Chorioamniotic Plate Smears in Predicting Intraamniotic Infection177
The Eight Most Frequent Blood-Borne Infectious Agents Affecting the Placenta and Fetus - A Synoptic Review193
Characterization of Placental Cytomegalovirus Infection by Immunocytochemistry215
Placental Pathology of Congenital Syphilis - Immunohistochemical Aspects223
Analysis of Human Trophoblast Tissue in Diagnosis of Embryonic Viral Infections231
Perinatal Infection of Parvovirus B19 in a Pregnant Veterinarian241
Isolated Trophoblast Cells for Studies of Placental Infection Advantages and Disadvantages247
New Methodologies for the Pathologic Diagnosis of Placental Infections - Immunohistochemistry, Immunofluorescence, In Situ Nucleic Acid Hybridization, and Polymerase Chain Reaction - A Review251
Methodological Approaches for Pathological and Experimental Studies of Placental Infections - A Workshop Report263
Genetic Imprinting in Human Embyrogenesis H19 and 1GF2 Gene Expression285
Regulation of NM23 Gene Expression in the Normal and Malignant Trophoblast By Growth Factors303
Human Trophoblast Interferons: Production, Purification, and Biochemical Characterization315
Human Trophoblast Cell Surface Molecules: HLA-G and Reproduction - A Review331
Novel Regulation of the Synthesis and Release of Human Placental Lactogen by High Density Lipoproteins - A Review339
Immunohistochemical Localization of New Placental Proteins (PP20, PP25, PP26) in Normal Pregnancy and Gestational Trophoblastic Disease355
Maternal Serum Type III Procollagen Peptide (P-III-P) and 7S Domain of Type IV Collagen (7S) as Indicators of Placental Damage Caused by Severe Toxemia of Pregnancy367
Platelet-Aggregation Inhibiting Activity of Human Placental Chorioepithelial Brush Border Membrane Vesicles and Basal Plasma Membrane Vesicles383
Formation of a hCG Varient with Truncated Peptide Moiety as a Biosynthetic Product In Vitro393
The Effect of In Vitro Methadone Administration on Trophoblast Tissue Opioid Receptors and Mediated Responses405
Biochemical Screening for Down Syndrome - A Workshop Report421
Trophoblastic Neoplasia - A Workshop Report423
Regulation of Human Extravillus Trophoblast (EVT) Cell Differentiation and Proliferation In Vitro - Role of Epidermal Growth Factor (EGF)427
Isolation of Cell Island Cytotrophoblast From First Trimester Human Placenta, and Comparison of Antigen Expression on Villus and Extravillus Cytotrophoblast443
Role of Transforming Growth Factor-[alpha] (TGF-[alpha]) and Epidermal Growth Factor (EGF) on Proliferation and Invasion by First Trimester Human Trophoblast455
Lack of Responsiveness to Transforming Growth Factor-[beta] (TGF-[beta]) - Induced Growth Arrest and Fibronectin Synthesis in BeWo Choriocarcinoma Cells469
Role of Uterine Cytokines in Pregnancy - A Review485
Direct Novel Regulation of Cyclooxygenase and Prostacyclin Synthase by Human Chorionic Gonadotropin in the Human Amnion503
The Role of Gestational Tissue Type II Phospholipase A[subscript 2] in Human Labor and Delivery - A Review515
Autocrine and Paracrine Control of Placental Blood Flow - A Workshop Report531
Compliance of the Human Placental Villus Membrane at Term: The Concept of the Fetoplacental Unit as an Autoregulating Gas Exchange System541
Amino Acid Uptake by the Cultured Human Placental Trophoblast: Exogenous Regulation559
Ca[superscript 2+] Channels in Human Term Trophoblast Cells In Vitro. A Study Using the Ca[superscript 2+]-Sensitive Dye Fura 2573
Is There Morphological Evidence of the Existence of Transtrophoblastic Channels in Human Placental Villi?581
List of Contributors597
Index607

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