HIV, Perinatal Infections and Therapy: The Role of the Placenta

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Proceedings from the 12th Rochester Trophoblast Conference, held in Autumn 1992 in Rochester, New York. The first part of the book addresses the role of the placenta in the transmission of the HIV infection, the central focus of the Conference. Other pre-natal infections, including CMV, Vaccina, Parvovirus, Syphillis, and Herpes Simplex, are then considered, and their implications for perinatal health investigated. The importance of cell regulation is also discussed, exploring the controlling factors which modulate the placental cell membrane and metabolic functions, such as genetic imprinting; the regulation of arachidonic acid cascade; autocrine role for human chorionic gonadotropin; biochemical screening for Down's Syndrome; the role of growth factors and interferon; the autoregulation of gas exchange; and the role of uterine cytokines. HENRY THIEDE is Professor of Obstetrics and Gynecology at the University of Rochester.RICHARD K. MILLERteaches in the University of Rochester Medical Center.
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Editorial Reviews

From the Publisher
"Follows the precedents established by the previous publications... contributors...are will established in the field of placentology." PLACENTA 16
Derived from the 12th Rochester Trophoblast Conference, held September 30-October 4, 1992, in Rochester, New York. Some 40 contributions (selected from the more than 220 presentations) evaluate all functions of the placenta and its extraembryonic membranes, but the role of the placenta in the vertical transmission of HIV was a central focus of the conference, with the aim of stimulating researchers to include emphasis on HIV in their work. The placenta has been associated with limiting the passage of the virus as well as being a site for concentrating the virus; less than 18% of the children born to HIV- positive mothers are positive themselves. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9781878822451
  • Publisher: Boydell & Brewer, Limited
  • Publication date: 6/15/1995
  • Series: Trophoblast Research, #8
  • Pages: 632

Table of Contents

In Memorium - Elizabeth M. Ramsey
Vertical Transmission of HIV: Possible Mechanisms and Placental Responses
Anti-HIV Monoclonal Antibodies Cross-React with Normal Human Trophoblast 19
In Vitro Infection of Hofbauer Cells with a Monocyte-Tropic Strain of HIV-1
The HIV-Exposed Placenta Morphologic Observations and Interpretation - A Review 47
Maternal-Fetal Transfer and Fetal Toxicity of Anti-HIV Drugs - A Review 67
Characterization of Macaque Placental Trophoblast and Hofbauer Cell Response to Zidovudine 83
Anti-HIV Therapy and the Placenta Workshop - A Workshop Report 97
Hematogenous Infections of the Placenta - An Interdisciplinary and Evolutionary Perspective 107
Human Natural Killer Cells Fail to Kill Herpes Simplex Virus Type1-Infected Term Villus Trophoblast Cells 137
Vaccinia Virus Infection of Cultured Human First Trimester Trophoblast 151
Placenta and Fetal Membrane in Genital Mycoplasmic Infection: Immunofluorescence and Electron Microscopic Study 161
The Value of Chorioamniotic Plate Smears in Predicting Intraamniotic Infection 177
The Eight Most Frequent Blood-Borne Infectious Agents Affecting the Placenta and Fetus - A Synoptic Review 193
Characterization of Placental Cytomegalovirus Infection by Immunocytochemistry 215
Placental Pathology of Congenital Syphilis - Immunohistochemical Aspects 223
Analysis of Human Trophoblast Tissue in Diagnosis of Embryonic Viral Infections 231
Perinatal Infection of Parvovirus B19 in a Pregnant Veterinarian 241
Isolated Trophoblast Cells for Studies of Placental Infection Advantages and Disadvantages 247
New Methodologies for the Pathologic Diagnosis of Placental Infections - Immunohistochemistry, Immunofluorescence, In Situ Nucleic Acid Hybridization, and Polymerase Chain Reaction - A Review 251
Methodological Approaches for Pathological and Experimental Studies of Placental Infections - A Workshop Report 263
Genetic Imprinting in Human Embyrogenesis H19 and 1GF2 Gene Expression 285
Regulation of NM23 Gene Expression in the Normal and Malignant Trophoblast By Growth Factors 303
Human Trophoblast Interferons: Production, Purification, and Biochemical Characterization 315
Human Trophoblast Cell Surface Molecules: HLA-G and Reproduction - A Review 331
Novel Regulation of the Synthesis and Release of Human Placental Lactogen by High Density Lipoproteins - A Review 339
Immunohistochemical Localization of New Placental Proteins (PP20, PP25, PP26) in Normal Pregnancy and Gestational Trophoblastic Disease 355
Maternal Serum Type III Procollagen Peptide (P-III-P) and 7S Domain of Type IV Collagen (7S) as Indicators of Placental Damage Caused by Severe Toxemia of Pregnancy 367
Platelet-Aggregation Inhibiting Activity of Human Placental Chorioepithelial Brush Border Membrane Vesicles and Basal Plasma Membrane Vesicles 383
Formation of a hCG Varient with Truncated Peptide Moiety as a Biosynthetic Product In Vitro 393
The Effect of In Vitro Methadone Administration on Trophoblast Tissue Opioid Receptors and Mediated Responses 405
Biochemical Screening for Down Syndrome - A Workshop Report 421
Trophoblastic Neoplasia - A Workshop Report 423
Regulation of Human Extravillus Trophoblast (EVT) Cell Differentiation and Proliferation In Vitro - Role of Epidermal Growth Factor (EGF) 427
Isolation of Cell Island Cytotrophoblast From First Trimester Human Placenta, and Comparison of Antigen Expression on Villus and Extravillus Cytotrophoblast 443
Role of Transforming Growth Factor-[alpha] (TGF-[alpha]) and Epidermal Growth Factor (EGF) on Proliferation and Invasion by First Trimester Human Trophoblast 455
Lack of Responsiveness to Transforming Growth Factor-[beta] (TGF-[beta]) - Induced Growth Arrest and Fibronectin Synthesis in BeWo Choriocarcinoma Cells 469
Role of Uterine Cytokines in Pregnancy - A Review 485
Direct Novel Regulation of Cyclooxygenase and Prostacyclin Synthase by Human Chorionic Gonadotropin in the Human Amnion 503
The Role of Gestational Tissue Type II Phospholipase A[subscript 2] in Human Labor and Delivery - A Review 515
Autocrine and Paracrine Control of Placental Blood Flow - A Workshop Report 531
Compliance of the Human Placental Villus Membrane at Term: The Concept of the Fetoplacental Unit as an Autoregulating Gas Exchange System 541
Amino Acid Uptake by the Cultured Human Placental Trophoblast: Exogenous Regulation 559
Ca[superscript 2+] Channels in Human Term Trophoblast Cells In Vitro. A Study Using the Ca[superscript 2+]-Sensitive Dye Fura 2 573
Is There Morphological Evidence of the Existence of Transtrophoblastic Channels in Human Placental Villi? 581
List of Contributors 597
Index 607
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