- Shopping Bag ( 0 items )
From The CriticsReviewer: Zhaoming Xu, BSc, MSc, PhD (University of British Columbia)
Description: This book provides comprehensive coverage of topics related to homocysteine, including chemistry, biochemistry, and physiology of homocysteine, possible causes of hyperhomocysteinemia, and clinical consequences associated with hyperhomocysteinemia.
Purpose: The purpose is to provide a comprehensive compilation of our present knowledge in homocysteine, clinical implications of high levels of homocysteine, and their possible amelioration by therapy.
Audience: This book is written for clinicians and scientists in a wide range of disciplines including biochemistry, epidemiology, genetics, and nutrition.
Features: A historical overview and a discussion of recent perspectives begin the book followed by two parts. Part one presents the chemistry, biochemistry, metabolism, and physiology of homocysteine. It also presents a detailed examination of the methionine cycle, biochemistry of S-adenosylmethionine, metabolic cycles of folic acid, vitamin B12 and B6 metabolism, and their interaction with homocysteine metabolism. Part two concentrates on the clinical disorders that lead to altered homocysteine status and the clinical dysfunctions associated with hyperhomocysteinemia.
Assessment: This book provides a reasonably in-depth discussion of the basic knowledge of homocysteine, but readers would be better served if it provided more in-depth discussion of the biochemical and molecular bases of some of the clinical dysfunctions discussed. Overall, the comprehensive inclusion of topics relevant to homocysteine and the extensive illustrations, including pathways, figures, tables, and flowcharts, render this a very good reference for research scientists, clinical practitioners, and nutritionists.