Homocysteine Metabolism: From Basic Science to Clinical Medicine / Edition 1by Ian Graham
Pub. Date: 12/31/1997
Publisher: Springer US
This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described. To date, evidence strongly supports the hypotheses that
This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described. To date, evidence strongly supports the hypotheses that Hyperhomocysteinemia is a strong independent determinant of vascular disease and Many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins.£/LIST£ The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions. Against this background of growing recognition of the importance of homocysteine as a factor in coronary artery disease, cerebrovascular disease, stroke, and peripheral vascular disease, the editors conceived of a state-of-the-art monograph on homocysteine and its relationships to disease. The contributors would be those scientists who, in fact, had written the history of this field of study over the past third of a century. The editors invited the leading investigators in the world to contribute chapters in their own areas of expertise to this monograph and to deliver those papers at the first International Meeting on Homocysteine in Ireland, which has emerged as an important study center and where the first cases of homocystinuria were reported more than three decades ago.
Table of Contents
Preface; I. Graham, et al. Biochemistry and Genetic Studies. The Regulation of Homocysteine Metabolism; J.D. Finkelstein. Methionine Kinetics and Balance; V.R.Young, et al. On the Formation and Fate of Total Plasma Homocysteine; H. Refsum, et al. Methylenetetrahydrofolate Reductase: Comparison of the Enzyme from Mammalian and Bacterial Sources; R.G. Matthews, et al. Genetics of Mammalian 5,10-Methylenetetrahydrofolate Reductase; R. Rozen. Thermolabile Methylenetetrahydrofolate Reductase; Soo-sang Kang, et al. The Long-Term Outcome in Homocystinuria; D.E.L. Wilcken, B. Wilcken. Characterization of the Human and Porcine Methionine Synthases and their Redox Partners; R. Banerjee, Zhiqiang Chen. Inherited Disorders of Folate and Cobalamin; D.S. Rosenblatt. Molecular Genetics of Cystathionine beta-Synthase in Homocystinuria and Vascular Disease; J.P. Kraus. Cystathionine beta-Synthase Deficiency: Metabolic Aspects; S.H. Mudd. Vitamins, Pathology, and Drug Therapy. Homocysteine and Other Metabolites in the Diagnosis and Follow-Up of Cobalamin and Folate Deficiencies; R.H. Allen, et al. Vitamin Status and Hyperhomocysteinemia in a Healthy Population; J.B. Ubbink. Association Between Plasma Homocysteine, Vitamin Status, and Extracranial Carotid-Artery Stenosis in the Framingham Study Population; J. Selhub, et al. Treatment of Mild Hyperhomocysteinemia; G.H.J. Boers, et al. Folate, Vitamin B12, and Neuropsychiatric Disorders; T. Bottiglieri. Vitamins, Homocysteine, and Neural Tube Defects; T.K.A.B. Eskes. The Etiology of Neural Tube Defects; J.M. Scott, et al. Plasma Homocysteine in Renal Failure, Diabetes Mellitus, and Alcoholism; B. Hultberg, et al. Homocysteine and Drug Therapy; P.M. Ueland, et al. Homocysteine, Cancer, and Cardiovascular Disease. Is Methionine Useful for the Prevention of Hyperhomocysteinemia-Associated Cardiovascular Disease? R.M. Hoffman, Yuying Tam. Synthesis of Homocysteine Thiolactone in Normal and Malignant Cells; H. Jakubowski. Folate Status: Modulation of Colorectal Carcinogenesis; J.B. Mason. The Hordaland Homocysteine Study: Lifestyle and Total Plasma Homocysteine in Western Norway; S.E. Vollset, et al. Blood Homocysteine Levels in the National Health and Nutrition Examination Survey (NHANES III) in the United States: Preliminary Findings by Age and Sex; I.H. Rosenberg, et al. Heritability of Plasma Homocysteine Concentration; M.R. Malinow, et al. Plasma Homocysteine and Coronary Artery Disease; M.R. Malinow. Homocysteine and Cerebral and Peripheral Vascular Disease; L. Brattström. Plasma Homocysteine and its Relationship to Cardiovascular Risk Factors in a Japanese Population; A. Araki, et al. Biological Chemistry of Thiols in the Vasculature and in Vascular-Related Disease; J.S. Stamler, A. Slivka. Intervention Studies and Concepts for the Future. Homocysteine and Vascular Disease: The European Concerted Action Project; I. Graham, et al. Prospective Studies of Homocysteine and Vascular Disease; M.J. Stampfer, P. Verhoef. A Meta-Analysis of Plasma Homocysteine as a Risk Factor for Arteriosclerotic Vascular Disease and the Potential Preventive Role of Folic Acid; C.J. Boushey, et al. Pathology of Homocystinuria; K.S. McCully. Lipoprotein(a), Homocysteine, and Atherogenesis; P.C. Harpel, W. Barth. Endothelial and Leukocyte-Mediated Mechanisms in Homocysteine-Associated Occlusive Vascular Disease; N.P.B. Dudman, S.E.T. Hale. Index.
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