Homocysteine Metabolism: From Basic Science to Clinical Medicine

Overview

This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described.
To date, evidence strongly supports the hypotheses that
• Hyperhomocysteinemia is a strong independent determinant...

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Paperback (Softcover reprint of the original 1st ed. 1997)
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Overview

This volume is the first comprehensive treatise on homocysteine to treat the topic from the basic biochemical, metabolic, genetic, and dietary determinants to disease relationships, including concepts of pathogenesis. In addition, the public health implications of these associations are described.
To date, evidence strongly supports the hypotheses that
• Hyperhomocysteinemia is a strong independent determinant of vascular disease and
• Many cases of hyperhomocysteinemia are amenable to homocysteine-lowering treatment with B-vitamins.£/LIST£ The strength of this evidence is prompting discussion of large-scale homocysteine-lowering interventions.
Against this background of growing recognition of the importance of homocysteine as a factor in coronary artery disease, cerebrovascular disease, stroke, and peripheral vascular disease, the editors conceived of a state-of-the-art monograph on homocysteine and its relationships to disease. The contributors would be those scientists who, in fact, had written the history of this field of study over the past third of a century. The editors invited the leading investigators in the world to contribute chapters in their own areas of expertise to this monograph and to deliver those papers at the first International Meeting on Homocysteine in Ireland, which has emerged as an important study center and where the first cases of homocystinuria were reported more than three decades ago.

The book contains black-and-white illustrations.

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Editorial Reviews

Kevin Cochran
This is a compilation of works on the basic science of homocysteine to clinical associations with disease. The book consists of material initially presented at the First International Meeting on Homocysteine held in July, 1995 in Ireland. The purpose is to establish an understanding of the metabolism and regulation of homocysteine and how it relates to clinical practice. This multiauthored text (112 international authors) is directed towards physicians in research and clinical practice. The book starts out with a review of the biochemistry and genetic studies of homocysteine. The contributors then progress through discussions of regulation of metabolism, enzymatic characteristics, vitamins and drug therapy, clinical expression of disease (neural tube defects, cancer, cardiovascular disease), and, finally, interventional studies and concepts for the future. Each chapter has an introduction and summary that are very helpful in facilitating discussion and emphasizing key points. The chapters are short and concise, but still incorporate a large volume of information. The authors had to limit references due to space. Some of the early chapters on the basic science of homocysteine become a little complex, particularly for someone unfamiliar with the subject. This book is a good resource for information on homocysteine. It is well organized with short and concise chapters that have lots of diagrams, figures, and tables. It reviews the past history of work on the subject, then recent research, and ends with a discussion of further research needed. It is well suited for professionals in the field of cardiology and for those who are basic science researchers wishing a connection withclinical application.
From The Critics
Reviewer: Kevin Cochran, MD (Loyola University Stritch School of Medicine)
Description: This is a compilation of works on the basic science of homocysteine to clinical associations with disease. The book consists of material initially presented at the First International Meeting on Homocysteine held in July, 1995 in Ireland.
Purpose: The purpose is to establish an understanding of the metabolism and regulation of homocysteine and how it relates to clinical practice.
Audience: This multiauthored text (112 international authors) is directed towards physicians in research and clinical practice.
Features: The book starts out with a review of the biochemistry and genetic studies of homocysteine. The contributors then progress through discussions of regulation of metabolism, enzymatic characteristics, vitamins and drug therapy, clinical expression of disease (neural tube defects, cancer, cardiovascular disease), and, finally, interventional studies and concepts for the future. Each chapter has an introduction and summary that are very helpful in facilitating discussion and emphasizing key points. The chapters are short and concise, but still incorporate a large volume of information. The authors had to limit references due to space. Some of the early chapters on the basic science of homocysteine become a little complex, particularly for someone unfamiliar with the subject.
Assessment: This book is a good resource for information on homocysteine. It is well organized with short and concise chapters that have lots of diagrams, figures, and tables. It reviews the past history of work on the subject, then recent research, and ends with a discussion of further research needed. It is well suited for professionals in the field of cardiology and for those who are basic science researchers wishing a connection with clinical application.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781461376453
  • Publisher: Springer US
  • Publication date: 4/30/2013
  • Series: Developments in Cardiovascular Medicine Series , #196
  • Edition description: Softcover reprint of the original 1st ed. 1997
  • Edition number: 1
  • Pages: 279
  • Product dimensions: 7.00 (w) x 10.00 (h) x 0.62 (d)

Meet the Author

Ian Graham
Ian Graham is an experienced author of illustrated nonfiction books on a wide range of topics, including aviation and spaceflight. In 25 years, he has written more than 200 books and numerous magazine articles.
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Table of Contents

Preface; I. Graham, et al. Biochemistry and Genetic Studies. The Regulation of Homocysteine Metabolism; J.D. Finkelstein. Methionine Kinetics and Balance; V.R.Young, et al. On the Formation and Fate of Total Plasma Homocysteine; H. Refsum, et al. Methylenetetrahydrofolate Reductase: Comparison of the Enzyme from Mammalian and Bacterial Sources; R.G. Matthews, et al. Genetics of Mammalian 5,10-Methylenetetrahydrofolate Reductase; R. Rozen. Thermolabile Methylenetetrahydrofolate Reductase; Soo-sang Kang, et al. The Long-Term Outcome in Homocystinuria; D.E.L. Wilcken, B. Wilcken. Characterization of the Human and Porcine Methionine Synthases and their Redox Partners; R. Banerjee, Zhiqiang Chen. Inherited Disorders of Folate and Cobalamin; D.S. Rosenblatt. Molecular Genetics of Cystathionine beta-Synthase in Homocystinuria and Vascular Disease; J.P. Kraus. Cystathionine beta-Synthase Deficiency: Metabolic Aspects; S.H. Mudd. Vitamins, Pathology, and Drug Therapy. Homocysteine and Other Metabolites in the Diagnosis and Follow-Up of Cobalamin and Folate Deficiencies; R.H. Allen, et al. Vitamin Status and Hyperhomocysteinemia in a Healthy Population; J.B. Ubbink. Association Between Plasma Homocysteine, Vitamin Status, and Extracranial Carotid-Artery Stenosis in the Framingham Study Population; J. Selhub, et al. Treatment of Mild Hyperhomocysteinemia; G.H.J. Boers, et al. Folate, Vitamin B12, and Neuropsychiatric Disorders; T. Bottiglieri. Vitamins, Homocysteine, and Neural Tube Defects; T.K.A.B. Eskes. The Etiology of Neural Tube Defects; J.M. Scott, et al. Plasma Homocysteine in Renal Failure, Diabetes Mellitus, and Alcoholism; B. Hultberg, et al. Homocysteine and Drug Therapy; P.M. Ueland, et al. Homocysteine, Cancer, and Cardiovascular Disease. Is Methionine Useful for the Prevention of Hyperhomocysteinemia-Associated Cardiovascular Disease? R.M. Hoffman, Yuying Tam. Synthesis of Homocysteine Thiolactone in Normal and Malignant Cells; H. Jakubowski. Folate Status: Modulation of Colorectal Carcinogenesis; J.B. Mason. The Hordaland Homocysteine Study: Lifestyle and Total Plasma Homocysteine in Western Norway; S.E. Vollset, et al. Blood Homocysteine Levels in the National Health and Nutrition Examination Survey (NHANES III) in the United States: Preliminary Findings by Age and Sex; I.H. Rosenberg, et al. Heritability of Plasma Homocysteine Concentration; M.R. Malinow, et al. Plasma Homocysteine and Coronary Artery Disease; M.R. Malinow. Homocysteine and Cerebral and Peripheral Vascular Disease; L. Brattström. Plasma Homocysteine and its Relationship to Cardiovascular Risk Factors in a Japanese Population; A. Araki, et al. Biological Chemistry of Thiols in the Vasculature and in Vascular-Related Disease; J.S. Stamler, A. Slivka. Intervention Studies and Concepts for the Future. Homocysteine and Vascular Disease: The European Concerted Action Project; I. Graham, et al. Prospective Studies of Homocysteine and Vascular Disease; M.J. Stampfer, P. Verhoef. A Meta-Analysis of Plasma Homocysteine as a Risk Factor for Arteriosclerotic Vascular Disease and the Potential Preventive Role of Folic Acid; C.J. Boushey, et al. Pathology of Homocystinuria; K.S. McCully. Lipoprotein(a), Homocysteine, and Atherogenesis; P.C. Harpel, W. Barth. Endothelial and Leukocyte-Mediated Mechanisms in Homocysteine-Associated Occlusive Vascular Disease; N.P.B. Dudman, S.E.T. Hale. Index.

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