Hormonally Active Agents in the Environment / Edition 1

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Overview

Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife.

This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decisionmakers.

This authoritative volume:

  • Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans.
  • Examines whether and how exposure to hormonally active agents occurs--in diet, in pharmaceuticals, from industrial releases into the environment--and why the debate centers on estrogens.
  • Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature.
The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Based upon a series of mandated NRC meetings; presents final draft sent to U.S. Congress, USEPA, CDC, Dept. of Interior.

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Editorial Reviews

Booknews
Various agencies of the US government requested the report in 1995 in response to growing public concern over the potential adverse effects on human health of what some call endocrine disruptors. It discusses mechanisms, sources and dynamics, dosimetry, effects on reproduction and development, neurological and immunological effects, carcinogenesis in animals and humans, ecological effects, and screening and monitoring. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780309064194
  • Publisher: National Academies Press
  • Publication date: 12/30/1999
  • Edition number: 1
  • Pages: 452
  • Product dimensions: 6.00 (w) x 9.10 (h) x 1.30 (d)

Table of Contents

Glossary
Executive Summary 1
1 Introduction 10
2 Hormonally Active Agents 27
3 Exposures: Sources and Dynamics of Hormonally Active Agents in the Environment 54
4 Dosimetry 82
5 Effects on Reproduction and Development 119
6 Neurologic Effects 171
7 Immunologic Effects 186
8 HAAs and Carcinogenesis in Animals 210
9 HAAs and Carcinogenesis in Humans 243
10 Ecologic Effects 274
11 Screening and Monitoring 296
References 311
App. A Reproductive Effects Caused by Diethylstilbesterol 399
App. B Biographical Information on the Committee on Hormonally Active Agents in the Environment 407
Addendum Endocrine Disruptor Screening and Testing Advisory Committee 410
Index 415
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