- Shopping Bag ( 0 items )
Doody's Review ServiceReviewer: Leah H Rubin, PhD (University of Illinois at Chicago College of Medicine)
Description: This book reassesses whether sex hormones are promising candidates for the treatment of dementia and age-related cognitive declines. To discuss this issue, it brings together basic science and clinical research studies that use a variety of experimental and observational methodologies to address inconsistencies between the negative effects of estrogen found in the Women's Health Initiative Memory Study (WHIMS) and data showing that estrogen may have a protective effect on age-related cognitive declines and dementia.
Purpose: The purpose is "to re-examine some of the basic and clinical underpinnings of our current knowledge in areas related to sex steroid hormones, cognitive aging, and dementia." This is important, given that a large percent of our population is elderly, the population is aging, and no known treatment completely reverses the effects of brain aging and dementia. World-renowned experts in basic and clinical research cover this topic comprehensively.
Audience: The intended audience includes gynecologists, endocrinologists, neurologists, psychologists, and behavioral neuroscientists. The book also would be useful to graduate students in psychology and behavioral neuroscience. Having some background in statistics will help.
Features: Part 1 of the book's six parts summarizes the most recent data from WHIMS and discusses alternative explanations for the negative results reported in WHIMS, including the critical window theory and the healthy cell bias. Possible alternative hormone treatments are discussed in part 2. Part 3 describes possible modifiers of the effect of estrogen on the brain including the role of progesterone regulation on estrogen, and estrogen's effect on mood and the hypothalamic-pituitary-adrenal axis. Part 4 covers possible genetic factors related to sex hormone metabolism, Alzheimer's disease, and apolipoprotein E. Parts 5 and 6 conclude with reviews of the relevance of testosterone and gonadotropins to the brain, cognition, and Alzheimer's disease in both women and men. The editor's introductions at the beginning of each chapter are the best part of the book. They help to weave together the individual chapters into a cohesive whole. Each chapter is well referenced.
Assessment: This is an excellent book for understanding where the field stands today regarding sex hormones for the treatment of brain aging and dementia.