Human Embryology and Developmental Biology: With STUDENT CONSULT Online Access / Edition 5

by Bruce M. Carlson

Overview

Master the concepts you need to know with Human Embryology and Developmental Biology. Dr. Bruce M. Carlson's clear explanations provide an easy-to-follow "road map" through the most up-to-date scientific knowledge, giving you a deeper understanding of the key information you need to know for your courses, exams, and ultimately clinical practice.

• Visualize normal and abnormal development with hundreds of superb clinical photos and embryological drawings.
• Access the fully searchable text online, view animations, answer self-assessment questions, and much more at www.studentconsult.com.

• Grasp the molecular basis of embryology, including the processes of branching and folding - essential knowledge for determining the root of many abnormalities.
• Understand the clinical manifestations of developmental abnormalities with clinical vignettes and Clinical Correlations boxes throughout.

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Product Details

ISBN-13:	2901455727949
Publication date:	03/06/2013
Pages:	520
Product dimensions:	8.50(w) x 10.80(h) x 0.60(d)

About the Author

Table of Contents

	Developmental Tables
	Carnegie Stages of Early Human Embryonic Development (Weeks 1-8)	xiii
	Major Developmental Events During the Fetal Period	xiv
Part I	Early Development and the Fetal-Maternal Relationship
Chapter 1	Getting Ready for Pregnancy	3
	Gametogenesis	3
	Preparation of the Female Reproductive Tract For Pregnancy	16
	Reproductive Target Tissues	20
Chapter 2	Transport of Gametes and Fertilization	27
	Ovulation and Egg and Sperm Transport	27
	Fertilization	32
Chapter 3	Cleavage and Implantation	43
	Cleavage	43
	Embryo Transport and Implantation	53
Chapter 4	Molecular Basis for Embryonic Development	65
	Fundamental Molecular Processes in Development	65
Chapter 5	Formation of Germ Layers and Early Derivatives	83
	Two-Germ-Layer Stage	83
	Gastrulation and the Three Embryonic Germ Layers	85
	Induction of the Nervous System	89
	Cell Adhesion Molecules	97
Chapter 6	Establishment of the Basic Embryonic Body Plan	103
	Development of the Ectodermal Germ Layer	103
	Development of the Mesodermal Germ Layer	108
	Development of the Endodermal Germ Layer	118
	Basic Structure of 4-Week Old Embryo	122
Chapter 7	Placenta and Extraembryonic Membranes	129
	Extraembryonic Tissues	129
	Chorion and Placenta	132
	Placenta After Birth	143
	Placenta and Membranes in Multiple Pregnancies	143
Chapter 8	Developmental Disorders: Causes, Mechanisms, and Patterns	151
	General Principles	152
	Causes of Malformations	155
	Developmental Disturbances Resulting in Malformations	164
Part II	Development of the Body Systems
Chapter 9	Integumentary, Skeletal and Muscular Systems	173
	Integumentary System	173
	Skeleton	183
	Muscular System	193
Chapter 10	Limb Development	209
	Initiation of Limb Development	209
	Regulative Properties and Axial Determination	210
	Outgrowth of Limb Bud	211
	Zone of Polarizing Activity and Morphogenetic Signaling	215
	Development of Limb Tissues	222
Chapter 11	Nervous System	233
	Establishment of Nervous System	233
	Early Shaping of Nervous System	234
	Histogenesis Within the Central Nervous System	234
	Craniocaudal Pattern Formation and Segmentation	240
	Peripheral Nervous System	245
	Autonomic Nervous System	249
	Later Structural Changes in the Central Nervous System	252
	Ventricles, Meninges, and Cerebrospinal Fluid Formation	264
	Cranial Nerves	265
	Development of Neural Function	267
Chapter 12	Neural Crest	277
	Origins of Neural Crest	277
	Migrations of Neural Crest	278
	Differentiation of Neural Crest Cells	278
	Major Divisions of Neural Crest	280
Chapter 13	Sense Organs	291
	Eye	292
	Ear	306
Chapter 14	Head and Neck	317
	Early Development of Head and Neck	317
	Fundamental Organization of Pharyngeal Region	319
	Development of Facial Region	321
	Development of Pharynx and Its Derivatives	335
Chapter 15	Digestive and Respiratory Systems and Body Cavities	353
	Digestive System	353
	Respiratory System	374
	Body Cavities	379
Chapter 16	Urogenital System	393
	Urinary System	393
	Genital System	401
	Sexual Duct System	412
	External Genitalia	419
Chapter 17	Cardiovascular System	429
	Developmental of Vascular System	429
	Developmental and Partitioning of Heart	446
	Initiation of Cardiac Function	455
	Fetal Circulation	456
Chapter 18	Fetal Period and Birth	477
	Growth and Form of Fetus	477
	Fetal Physiology	477
	Parturition	492
	Adaptations to Postnatal Life	494
	Overview	496
	Answers to Clinical Vignettes and Review Questions	499
	Index	507

Editorial Reviews

3 Stars from Doody

This new softcover book on embryology is aptly named. It covers normal human development and clinical embryology, with emphasis throughout on relevant molecular and experimental studies. The purpose is to introduce the structural changes in the embryo and fetus in the context of the rapid and revolutionary scientific developments in the field. The stated goal is to do this in a manner that is understandable to the beginning student and streamlined enough for the reduced emphasis on embryology in medical curricula. The book is intended for first-year medical and allied health students. The excellent coverage of clinical topics such as congenital defects, treatment of infertility, prenatal imaging, and the genetic manipulation of embryos will make this appealing to medical students. The detailed coverage of the cellular and molecular basis of development, however, points to a different audience, perhaps graduate students, advanced medical students, or more specialized health professionals. The chapters in the first half of the book emphasize early development, the body plan, mother and fetus, molecular and cellular concepts, and related clinical topics. The second half covers the body systems. The book's unique feature is its focus on the biology of development. No other book in its class has its detail at the molecular and genetic level and its scope. It includes some histology and cell biology, and the descriptive figures on the body systems tend to emphasize more realistic changes in structures instead of schematics. The author does an admirable job on the science of development and the current state of medical embryology, but the detail works against the beginner, at least for a shortembryology course. Although the book may not stand alone for any particular course, it would be an excellent reference for advanced students in a variety of areas in biology and medicine. There is much of value in this unique book.

Larry R. Cochard

Combines an introduction to the molecular and mechanistic basis of human development with classic descriptive embryology. Presents the latest findings in the fields of genetics, cell biology, endocrinology, reproduction, pathology, and anatomy, discussing their effect on human developmental biology. Includes review question with answers. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

Reviewer: Erin Rae Leslie, PhD (Midwestern University)
Description: The fifth edition of this classic human embryology book includes extensive revisions incorporating updates on human embryology and early development, clinical correlations, review questions, and excellent illustrations. The fourth edition was published in 2008.
Purpose: The goal is to provide up-to-date information on the structures and mechanisms of early human development to medical students and medical professionals. This new edition is justified by the proliferation of new information on many aspects of embryonic development and the molecular regulation of these processes.
Audience: It is most appropriate for medical and graduate students learning embryology and for professionals as a reference.
Features: This book covers in depth the structures and mechanisms of early human embryonic development from the prefertilization period through organogenesis and provides access to the Student Consult website, which includes downloadable full-color illustrations and animated videos showing select developmental processes. The book includes numerous boxed clinical correlations, case vignettes, and review questions with answers. The illustrations are excellent and include several new scanning electron micrographs and clinical case photographs. The revision of chapter 12, on the neural crest, is especially valuable as it effectively consolidates the latest information regarding the complex role of this tissue in development. Grouping the integumentary, skeletal, and muscular systems together in chapter 9 may confuse readers, as these tissues primarily arise from different primordia. The extensive passages on molecular processes and signaling pathways may be daunting to readers lacking a foundation in molecular biology or genetics, and the book would benefit from placing these sections under separate subheadings. In addition, it would be helpful to include chapter information in the page headers, as well as a glossary.
Assessment: This offers well-written, in-depth coverage of early human development that is appropriate for medical and graduate students. A comparable book, Langman's Medical Embryology, 12th edition, Sadler (Lippincott Williams & Wilkins, 2012), covers a similar scope of topics, but is more concise, includes a glossary, and restricts its coverage of molecular-level processes.

Doody's Review Service

"This book covers in depth the structures and mechanisms of early human embryonic development from the prefertilization period through organogenesis and provides access to the Student Consult website, which includes downloadable full-color illustrations and animated videos showing select developmental processes. The book includes numerous boxed clinical correlations, case vignettes, and review questions with answers. The illustrations are excellent and include several new scanning electron micrographs and clinical case photographs. The revision of chapter 12, on the neural crest, is especially valuable as it effectively consolidates the latest information regarding the complex role of this tissue in development. Grouping the integumentary, skeletal, and muscular systems together in chapter 9 may confuse readers, as these tissues primarily arise from different primordia. The extensive passages on molecular processes and signaling pathways may be daunting to readers lacking a foundation in molecular biology or genetics, and the book would benefit from placing these sections under separate subheadings. In addition, it would be helpful to include chapter information in the page headers, as well as a glossary."-Erin Leslie, PhD(Midwestern University) Doody Review: 4 stars

From the Publisher