Human Fungal Pathogens
Some yeasts and molds that are common in the environment can infect humans and cause a range of diseases, from superficial (e.g., athlete's foot) to severe (e.g., cryptococcal meningitis). These pathogenic fungi pose a particular threat to immunocompromised individuals, such as those living with HIV/AIDS, and are becoming a leading cause of morbidity and mortality worldwide.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology and diseases of fungal pathogens. Contributors examine their life cycles, nutritional and metabolic requirements, and morphological characteristics, as well as their interactions with humans-their modes of dissemination and penetration, the mechanisms they use to evade the immune system, and their effects on target organs. Specific chapters are devoted to the major disease-causing fungi, such as Candida, Aspergillus, and Cryptococcus species. The ecology, evolution, and epidemiology of human fungal pathogens are also explored.

This volume includes discussions about options for diagnosing and treating fungal infections, as well as challenges presented by emerging drug-resistant strains. It is therefore an essential reference for all fungal biologists and medical professionals who wish to understand and manage these difficult pathogens.
1133509084
Human Fungal Pathogens
Some yeasts and molds that are common in the environment can infect humans and cause a range of diseases, from superficial (e.g., athlete's foot) to severe (e.g., cryptococcal meningitis). These pathogenic fungi pose a particular threat to immunocompromised individuals, such as those living with HIV/AIDS, and are becoming a leading cause of morbidity and mortality worldwide.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology and diseases of fungal pathogens. Contributors examine their life cycles, nutritional and metabolic requirements, and morphological characteristics, as well as their interactions with humans-their modes of dissemination and penetration, the mechanisms they use to evade the immune system, and their effects on target organs. Specific chapters are devoted to the major disease-causing fungi, such as Candida, Aspergillus, and Cryptococcus species. The ecology, evolution, and epidemiology of human fungal pathogens are also explored.

This volume includes discussions about options for diagnosing and treating fungal infections, as well as challenges presented by emerging drug-resistant strains. It is therefore an essential reference for all fungal biologists and medical professionals who wish to understand and manage these difficult pathogens.
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Overview

Some yeasts and molds that are common in the environment can infect humans and cause a range of diseases, from superficial (e.g., athlete's foot) to severe (e.g., cryptococcal meningitis). These pathogenic fungi pose a particular threat to immunocompromised individuals, such as those living with HIV/AIDS, and are becoming a leading cause of morbidity and mortality worldwide.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the biology and diseases of fungal pathogens. Contributors examine their life cycles, nutritional and metabolic requirements, and morphological characteristics, as well as their interactions with humans-their modes of dissemination and penetration, the mechanisms they use to evade the immune system, and their effects on target organs. Specific chapters are devoted to the major disease-causing fungi, such as Candida, Aspergillus, and Cryptococcus species. The ecology, evolution, and epidemiology of human fungal pathogens are also explored.

This volume includes discussions about options for diagnosing and treating fungal infections, as well as challenges presented by emerging drug-resistant strains. It is therefore an essential reference for all fungal biologists and medical professionals who wish to understand and manage these difficult pathogens.

Product Details

ISBN-13: 9781621820758
Publisher: Cold Spring Harbor Laboratory Press
Publication date: 12/31/2014
Pages: 577
Product dimensions: 7.20(w) x 10.20(h) x 1.30(d)

Table of Contents

Preface

Introduction and General Principles and Evolution of Fungal Pathogens

1. The Spectrum of Fungi that Infect Humans
Julia R. Köhler, Arturo Casadevall, and John Perfect

2. Evolutionary Perspectives on Human Fungal Pathogens
John W. Taylor

3. Sexual Reproduction and Human Fungal Pathogens
Joseph Heitman, Dee A. Carter, Paul S. Dyer, and David R. Soll

4. Functional Profiling of Human Fungal Pathogen Genomes
Alexi I. Goranov and Hiten D. Madhani

5. Rapid Mechanisms for Generating Genome Diversity: Whole Ploidy Shifts, Aneuploidy, and Loss of Heterozygosity
Richard J. Bennett, Anja Forche, and Judith Berman

Host immunity and fungal infection

6. Adaptive Immunity to Fungi
Akash Verma, Marcel Wüthrich, George Deepe, and Bruce Klein

7. Innate Defense Against Fungal Pathogens
Rebecca A. Drummond, Sarah L. Gaffen, Amy G. Hise, and Gordon D. Brown

8. Mendelian Genetics of Human Susceptibility to Fungal Infection
Michail S. Lionakis, Mihai G. Netea, and Steven M. Holland

Microbial virulence mechanisms

9. Fungal Biofilms, Drug Resistance, and Recurrent Infection
Jigar V. Desai, Aaron P. Mitchell, and David R. Andes

10. Fungal Pathogens: Survival and Replication Within Macrophages
Andrew S. Gilbert, Robert T. Wheeler, and Robin C. May

11. Fungal Morphogenesis
Xiaorong Lin, J. Andrew Alspaugh, Haoping Liu, and Steven Harris

12. Host Cell Invasion by Medically Important Fungi
Donald C. Sheppard and Scott G. Filler

13. Metabolism in Fungal Pathogenesis
Iuliana V. Ene, Sascha Brunke, Alistair J.P. Brown, and Bernhard Hube

Treatment strategies

14. Fungal diagnostics
Thomas R. Kozel and Brian Wickes

15. Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches
Terry Roemer and Damian J. Krysan

16. Fungal Vaccines and Immunotherapeutics
Evelyn Santos and Stuart M. Levitz

17. Antifungal Pharmacokinetics and Pharmacodynamics
Alexander J. Lepak and David R. Andes

18. Treatment Principles for the Management of Mold Infections
Dimitrios P. Kontonyiannis and Russell E. Lewis

19. Treatment Principles for Candida and Cryptococcus
Laura C. Whitney and Tihana Bicanic

20. Antifungal Clinical Trials and Guidelines: What We Know and Do Not know
Peter G. Pappas

21. Mechanisms of Antifungal Drug Resistance
Leah Cowen, Dominique Sanglard, Susan J. Howard, P. David Rogers, and
David S. Perlin

Fungal pathogens

22. Cryptococcus neoformans and Cryptococcus gattii, the Etiologic Agents of Cryptococcosis
Kyung J. Kwon-Chung, James A. Fraser, Tamara L. Doering, Zhuo Wang,
Guilhem Janbon, Alexander Idnurm, and Young-Sun Bahn

23. The Candida Pathogenic Species Complex
Siobhán A. Turner and Geraldine Butler

24. Aspergillus fumigatus and Related Species
Janyce A. Sugui, Kyung J. Kwon-Chung, Praveen Juvvadi, Jean-Paul Latge, and
William J. Steinbach

25. Thermally Dimorphic Human Fungal Pathogens—Polyphyletic Pathogens With a Convergent Pathogenicity Trait
Anita Sil and Alex Andrianopoulos

26. Fungi on the skin: Dermatophytes and Malassezia
Theodore C. White, Keisha Findley, Thomas L. Dawson Jr., Annika Scheynius, Teun Boekhout, Christina A. Cuomo, Jun Xu, and Charles W. Saunders

27. Human Fungal Pathogens of Mucorales and Entomophthorales
Leonel Mendoza, Raquel Vilela, Kerstin Voelz, Ashraf S. Ibrahim, Kerstin Voigt,
and Soo Chan Lee

28. Black Molds and Melanized Yeasts Pathogenic to Humans
Anuradha Chowdhary, John Perfect, and G. Sybren de Hoog

29. Pneumocystis
Francis Gigliotti, Andrew H. Limper, and Terry Wright

30. The Human Mycobiome
Patrick C. Seed

Index
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