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Doody's Review ServiceReviewer: Roger W. Melvold, PhD (Northwestern University Feinberg School of Medicine)
Description: This is the latest in a series, based on the Genome Data Base (GDB), presenting the status of the human genome map up through 1995. The volume includes a discussion of impending changes in the organization of the GBD, information about electronic access, and contact information for the various commitees responsible for each chromosome, etc.
Purpose: As a measure of the rapid growth in the data resulting from the emphasis on human gene mapping, the edition is 25 percent larger than the 1994 listing. More than 6,200 gene loci/markers are included.
Audience: The volume is directed at geneticists, primarily those involved in human gene mapping.
Features: The data is well organized first in a comprehensive alphabetical listing, then in separate tables for each autosomal chromosome plus the X and Y chromosomes. Additional tables are included for mitochondrial genes, DNA polymorphisms detected by various probes, loci associated with specific human diseases, and chromosomal changes associated with tumor cells. Tables are included to provide information on homology of chromosomal regions between human and mouse, nonhuman primates, and other vertebrates. Each table includes references. There a few black-and-white illustrations.
Assessment: The volume, now being reviewed in late 1996, is already out of date, as is true for all such compendia of rapidly proliferating data, but nevertheless is useful as a reference source for the majority of mapped loci and markers. It should be available in libraries. Individual copies will be useful probably only to those most heavily involved in human gene mapping.