The Human Genome: A User's Guide / Edition 1

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1999 Trade Paperback New with no dust jacket 0123334608. Trade Paperback. New copy. "Using the theme of sexuality, the authors discuss basic genetics information and analytical ... techniques and the genetic basis of cancer, AIDS, and mental illness. A very complex subject is broken into understandable pieces and then put back together to form a complicated but comprehensible whole. "; 0.79 x 8.9 x 5.98 Inches; 415 pages. Read more Show Less

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Overview

The Human Genome: A User's Guide conveys both the essence and the excitement of modern human genetics. Incorporating all of researchers' latest discoveries, the authors ground their work in the discussion of a major function of the human gene: that of sex determination and development. This focus opens the discussion to the interactions between science and society. Hawley and Mori take care to examine the process of genetic analysis and to explore relevant topics such as the genetics of cancer, behavior and personality, AIDS, mental illness, cloning, and gene therapy. The reader gains sophisticated insight into human heredity beyond the misconceptions of folklore.
R. Scott Hawley is a Professor of Genetics at the University of California at Davis. Before moving to UC Davis in 1991, he was on the faculty at Albert Einstein College of Medicine for nine years. His research interests include the etiology of birth defects and the genetics of cancer. He has published more than 50 articles in scientific journals. He has taught human genetics to undergraduates (both non-biology majors and biology majors), graduate students, and medical students.
Catherine Mori is an accomplished health education writer. Her previous writing has concentrated on drug- and alcohol-related risks to health and on the treatment and prevention of drug and alcohol addiction. Her interest in human genetics began when she attended Dr. Hawley's Human Genetics course for non-majors at UC Davis. She has worked extensively as a management consultant in the private sector and is currently working on her Master's degree in Business Administration at the University of California at Davis.

Audience: Lower-division undergraduate students in courses in genetics, human genetics, and molecular biology; medical students; non-majors taking genetics or human genetics courses.

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Editorial Reviews

Michael Cummings
This book on human genetics is an overview of human genetic research and its impact on society. The purpose is to introduce and integrate the principles of human genetics into everyday life. Undergraduate non-science majors and health pre-professional students will benefit from this book. Beginning with a chapter on the mechanics of gene expression, the authors use a conversational tone and personal perspectives to outline the basic concepts of genetics using human disorders, case histories, and boxed examples in six sections each composed of three to five chapters. In just over 350 pages, topics ranging from sex determination/differentiation, nondisjunction, cloning, human gene mapping, cancer, behavior genetics, AIDS, and gene therapy are outlined and illustrated by examples. An appendix contains suggested readings culled from articles in popular magazines such as Scientific American and Discover through general interest journals such as Science and Nature and specialized journals such as theAmerican Journal of Human Genetics. Definitions of about 300 of the terms used in the book are found in the glossary, which is followed by a fairly detailed index. The illustrations are mainly black-and-white diagrams supplemented with a few photographs. The illustrations are carefully chosen, well-executed, and reinforce the concepts discussed. The writing, examples, and pace at which topics are introduced and discussed all indicate that the principal author is undoubtedly an accomplished teacher who lectures with enthusiasm and gets his point across in an informative and perhaps lighthearted manner. The text reflects this approach, and not only are theintroductory concepts presented, but genetics is integrated into the fabric of everyday life. The narrative takes a broad overview, and as a result, this is an accessible book that should appeal to both students and professionals seeking an introduction to recent advances in human genetics and its impact on society. Because of this approach, the details of some topics are disappointingly limited. For example, a section on the mechanism of inactivation of human X chromosomes does not include genetic control of this process, rather only the conversion of the chromosome into a hetarochromatic mass is covered. Readers seeking more details or discussion of mechanisms should consult other more advanced texts. This text is designed to appeal to a wide audience, and there are few if any texts at this level. There are several texts with a more detailed and rigorous approach to introductory human genetics, including Mange's Basic Human Genetics, 2nd Edition (Sinauer Association, Inc., 1998) and Strachan's Human Molecular Genetics (John Wiley & Sons, 1999), but these books are longer and more ambitious in coverage.
Stephanie Sherman
"...a wonderful addition to the human genetics landscape."
From The Critics
Reviewer:Michael Cummings, PhD (University of Illinois at Chicago)
Description:This book on human genetics is an overview of human genetic research and its impact on society.
Purpose:The purpose is to introduce and integrate the principles of human genetics into everyday life.
Audience:Undergraduate non-science majors and health pre-professional students will benefit from this book.
Features:Beginning with a chapter on the mechanics of gene expression, the authors use a conversational tone and personal perspectives to outline the basic concepts of genetics using human disorders, case histories, and boxed examples in six sections each composed of three to five chapters. In just over 350 pages, topics ranging from sex determination/differentiation, nondisjunction, cloning, human gene mapping, cancer, behavior genetics, AIDS, and gene therapy are outlined and illustrated by examples. An appendix contains suggested readings culled from articles in popular magazines such as Scientific American and Discover through general interest journals such as Science and Nature and specialized journals such as theAmerican Journal of Human Genetics. Definitions of about 300 of the terms used in the book are found in the glossary, which is followed by a fairly detailed index. The illustrations are mainly black-and-white diagrams supplemented with a few photographs. The illustrations are carefully chosen, well-executed, and reinforce the concepts discussed. The writing, examples, and pace at which topics are introduced and discussed all indicate that the principal author is undoubtedly an accomplishedteacher who lectures with enthusiasm and gets his point across in an informative and perhaps lighthearted manner. The text reflects this approach, and not only are the introductory concepts presented, but genetics is integrated into the fabric of everyday life. The narrative takes a broad overview, and as a result, this is an accessible book that should appeal to both students and professionals seeking an introduction to recent advances in human genetics and its impact on society. Because of this approach, the details of some topics are disappointingly limited. For example, a section on the mechanism of inactivation of human X chromosomes does not include genetic control of this process, rather only the conversion of the chromosome into a hetarochromatic mass is covered. Readers seeking more details or discussion of mechanisms should consult other more advanced texts.
Assessment:This text is designed to appeal to a wide audience, and there are few if any texts at this level. There are several texts with a more detailed and rigorous approach to introductory human genetics, including Mange's Basic Human Genetics, 2nd Edition (Sinauer Association, Inc., 1998) and Strachan's Human Molecular Genetics (John Wiley & Sons, 1999) , but these books are longer and more ambitious in coverage.
Library Journal
Using the theme of sexuality, the authors discuss basic genetics information and analytical techniques and the genetic basis of cancer, AIDS, and mental illness. A very complex subject is broken into understandable pieces and then put back together to form a complicated but comprehensible whole. Copyright 1999 Cahners Business Information.
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Product Details

  • ISBN-13: 9780123334602
  • Publisher: Elsevier Science
  • Publication date: 9/1/1998
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 415
  • Product dimensions: 5.92 (w) x 8.93 (h) x 0.73 (d)

Table of Contents

Preface
Sect. I The Basics of Heredity
1 The Answer in a Nut Shell: Genes, Proteins, and the Meaning of Life
2 Mendel and the Concept of the Gene
3 How Genes Work: The Story of How Genes Encode Proteins, or "The Central Dogma of Molecular Biology"
4 How Genes Move: Chromosomes and the Physical Basis of the Laws of Mendel
5 Absent Essentials and Monkey Wrenches: How Mutations Produce a Phenotype
Sect. II How Genes Determine Our Sex
6 Sex and Chromosomes, Sex and Hormones, Sex and...
7 Sex Causes Problems: The Inactivation of the Second X Chromosome
8 Gender, Identification and Sexual Orientation
Sect. III When Meiosis of Mendelian Inheritance Fails
9 Failed Chromosome Segregation and the Etiology of Down Syndrome
10 Extreme Mutation: Triplet Repeat Syndromes
11 Imprinting or Epigenetic Changes in Genes and Chromosomes
Sect. IV Human Genes
12 Introduction to Gene Cloning
13 DNA Polymorphisms as Genetic Markers in Humans (and the Miracle of PCR)
14 Human Gene Mapping: A General Approach
15 Cystic Fibrosis
16 Mammoth Genes: Muscular Dystrophy and Neurofibromatosis
17 Genes and Cancer
Sect. V Interactions of Genes and the Environment
18 Multifactorial Inheritance: Toward Finding the Genes for Manic Depression and Schizophrenia
19 The Monoamine Oxidase A Gene and a Genetic Basis for Criminality?
20 Genetics of the Human AIDS Virus
Sect. VI Prenatal Diagnosis
21 Methods of Prenatal Diagnosis
22 Potential for Gene Therapy
Epilogue: Fears, Faith, and Fantasies
App. Suggested Additional Readings
Glossary
Index
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