Human Molecular Genetics / Edition 4

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Human Molecular Genetics is an established and class-proven textbook for upper-level undergraduates and graduate students which provides an authoritative and integrated approach to the molecular aspects of human genetics. While maintaining the hallmark features of previous editions, the Fourth Edition has been completely updated. It includes new Key Concepts at the beginning of each chapter and annotated further reading at the conclusion of each chapter, to help readers navigate the wealth of information in this subject.

The text has been restructured so genomic technologies are integrated throughout, and next generation sequencing is included. Genetic testing, screening, approaches to therapy, personalized medicine, and disease models have been brought together in one section. Coverage of cell biology including stem cells and cell therapy, studying gene function and structure, comparative genomics, model organisms, noncoding RNAs and their functions, and epigenetics have all been expanded.

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Editorial Reviews

Doody's Review Service
Reviewer: Luis F. Escobar, MD, MS (St. Vincent Hospital and Health Care Center)
Description: Masterfully planned with a well-thought-out design, this fourth edition of an extensive compilation of current molecular genetics knowledge is not limited to recent technological advances, but also provides a basic review of concepts in preparation for the introduction of complex information derived from the new molecular genetics science. This is an exhaustive and well done update of the 2004 edition.
Purpose: Recognizing the new era of bioinformatics triggered by the completion of the Human Genome Project, the authors aim to provide an extensive review of human molecular genetics. Their book compiles in an exquisite manner the vast amount of current information on molecular genetics that enables understanding of medical genetic disorders. The authors meet their goals with this wonderful masterpiece.
Audience: Although the authors do not target a specific audience, the information they provide is of use to all genetics professionals, from early clinical students to experienced practitioners, from graduate students to experienced scientists. Teachers in undergraduate education may find this an excellent guide for updating their curriculum.
Features: Logically planned, the book provides basic traditional genetic concepts such as nucleic acid structure and gene expression and transitions slowly to more complex information such as the influence of molecular mechanisms on cell therapy. Chapters begin with key concepts and are filled with wonderful and well-designed illustrations that are both helpful and inviting. Images can be downloaded in different formats from the book's website. The index is complete and it allows easy scanning of the chapters. This book is designed not only to provoke the curiosity of the reader, but also to invite review of the content.
Assessment: This book stands alone as a must have for any genetics professional. The degree of detail and depth of the information is unique. Future editions will be necessary.
From the Publisher
Praise for the Third Edition:

"This book is an excellent companion for students in human genetics or for researchers that want to gain background and knowledge in this field." Human Genetics Journal

"[Human Genetics] is a well-crafted piece that will entertain and educate interested readers….Lewis uses vibrant language and insightful allegories to explain difficult scientific concepts….It is certainly an up-to-date account of this quickly evolving field." Quarterly Review of Biology

"Even with the rapidly expanding knowledge about the human genome, Human Molecular Genetics provides a strong foundation for students. It is recommended as a reference book for both academic health science and other basic science libraries."
Vol. 8, No 3 - March 2005
Journal of Medical Genetics
"...Timely, up to date, and has enormous and comprehensive coverage... ...This book is a good buy, an excellent read, and is to be strongly recommended."
2004, 41
SciTech Book News
Provides introductory material on DNA and chromosomes...describes principles and applications of cloning and molecular hybridization...presents a guide to...the human genome and human genes...examines mapping of the human genome, study of genetic diseases, and dissection and manipulation of genes.
SciTech Book News
Provides introductory material on DNA and chromosomes...describes principles and applications of cloning and molecular hybridization...presents a guide to...the human genome and human genes...examines mapping of the human genome, study of genetic diseases, and dissection and manipulation of genes.
Provides introductory material on DNA and chromosomes and describes principles and applications of cloning and molecular hybridization, then presents a guide to the structure, evolution, and mutational instability of the human genome and human genes, and examines mapping of the human genome, study of genetic diseases, and dissection and manipulation of genes. This second edition contains new material on cell types, DNA microarrays, and how to obtain the latest data from Web-based resources. This edition also features the early use of hierarchical figures and flow charts to introduce principles described in later chapters, and a two-column layout to improve clarity. Strachan and Read teach genetics at the University of Newcastle, UK, and the University of Manchester, UK. Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780815341499
  • Publisher: Taylor & Francis
  • Publication date: 3/31/2010
  • Edition description: New Edition
  • Edition number: 4
  • Pages: 807
  • Sales rank: 334,065
  • Product dimensions: 8.30 (w) x 10.80 (h) x 1.40 (d)

Meet the Author

Tom Strachan is Scientific Director of the Institute of Human Genetics and Professor of Human Molecular Genetics at Newcastle University, UK, and is a Fellow of the Academy of Medical Sciences and a Fellow of the Royal Society of Edinburgh. Tom's early research interests were in multigene family evolution and interlocus sequence exchange, notably in the HLA and 21-hydroxylase gene clusters. While pursuing the latter, he became interested in medical genetics and disorders of development. His most recent research has focused on developmental control of the vertebrate cohesion regulators Nipbl and Mau-2.

Andrew Read is Emeritus Professor of Human Genetics at the University of Manchester, UK and a Fellow of the Academy of Medical Sciences. Andrew has been particularly concerned with making the benefits of DNA technology available to people with genetic problems. He established one of the first DNA diagnostic laboratories in the UK over 20 years ago (it is now one of two National Genetics Reference Laboratories), and was founder chairman of the British Society for Human Genetics, the main professional body in this area. His own research is on the molecular pathology of various hereditary syndromes, especially hereditary hearing loss.

Drs. Strachan and Read were recipients of the European Society of Human Genetics Education Award.

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Table of Contents

1. Nucleic Acid Structure and Gene Expression
2. Chromosome Structure and Function
3. Genes in Pedigrees and Populations
4. Cells and Cell-Cell Communication
5. Principles of Development

6. Amplifying DNA: Cell-based DNA Cloning and PCR
7. Nucleic Acid Hybridization: Principles and Applications
8. Analyzing the Structure and Expression of Genes and Genomes

9. Organization of the Human Genome
10. Model Organisms, Comparative Genomics and Evolution
11. Human Gene Expression
12. Studying Gene Function in the Post-Genome Era

13. Human Genetic Variability and its Consequences
14. Genetic Mapping of Mendelian Characters
15. Mapping Genes Conferring Susceptibility to Complex Disease
16. Identifying Human Disease Genes and Susceptibility Factors
17. Cancer Genetics

18. Genetic Testing of Individuals
19. Pharmacogenetics, Personalized Medicine, and Population Screening
20. Genetic Manipulation of Animals for Modeling Disease and Investigating Gene Function
21. Genetic Approaches to Treating Disease


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