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Doody's Review ServiceReviewer: Michael C Cunningham, M.D.(Ochsner Clinic Foundation)
Description: This multiauthored book on hypertension is divided into seven distinct sections. The first section demonstrates models of hypertension with each subsequent section focusing on particular research modalities and protocols used to investigate the pathophysiology of hypertension.
Purpose: The book is intended to educate readers about hypertension, updating their knowledge of the current methods in hypertensive research and stimulating new ideas for further investigation.
Audience: Intended for novice and expert researchers in the field, this book concentrates on the molecular side of research. The authors specialize in this area and have gathered a wealth of information and techniques from several other sources. With this knowledge, these experts have created the reference in this field.
Features: Initially, the book demonstrates how to engineer various genetically altered mice as models for hypertension. Then, in a well outlined fashion, it discusses and expounds on the techniques of pharmacogenetics and pharmacogenomics. This includes various protein analyses and gene transfer using viral vectors and then on to assorted aspects of stem cell research. There is also a section dedicated to information technology and its indispensable role in pharmacogenomics data collection and interpretation. The illustrations are particularly well placed, usually complementing or illustrating a confusing method.
Assessment: The authors have created a much needed book in the area of molecular hypertension that serves beginners and experts in the field, not only to help them continue their current work, but also to stimulate new thought processes and ideas that will provide further insight into this deadly disease and identify new targets for pharmacologic therapy.