Hypertension: A Companion to Brenner and Rector's The Kidney

Overview

The revised and updated 2nd Edition provides a logical, practical framework for managing patients with hypertension. Today's leading experts discuss all aspects of the field—from pathophysiology, pharmacological treatments, and lifestyle modifications to secondary hypertension and cardiovascular complications.

• Assesses the risks of specific pharmacological treatments
• offers expert analysis of recent ...

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Overview

The revised and updated 2nd Edition provides a logical, practical framework for managing patients with hypertension. Today's leading experts discuss all aspects of the field—from pathophysiology, pharmacological treatments, and lifestyle modifications to secondary hypertension and cardiovascular complications.

• Assesses the risks of specific pharmacological treatments
• offers expert analysis of recent clinical trials
• and provides
• Delivers strategies for managing patients with comorbid conditions such as diabetes, renal disease, and ischemic heart disease.
• Explains the role of vascular biology in the pathogenesis of hypertension.

• Includes 11 new chapters: The National High Blood Pressure Education Program
• Angiotensin 1-7
• Aldosterone and Minealocorticoids
• Vasodilator Peptides
• Clinical Outcome Trials of Hypertension with Angiotensin Receptor Blockers
• ACE Inhibitor Trials: Effects in Hypertension
• Obesity and Hypertension: Role of Diet Drugs
• Exercise and Hypertension
• Pharmacokinetics of Antihypertensive Drugs
• Hypertension in Children
• and Dietary Approaches to Hypertension Management: The DASH Studies.
• Provides complete revisions of all other existing chapters.
• Features new clinical pearls
• evidence-based therapeutic ladders that summarize key therapy regimens
• and preferred treatment boxes that highlight important information.

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Editorial Reviews

Doody's Review Service
Reviewer: Paolo Fanti, M.D.(University of Texas Health Sciences Center at San Antonio)
Description: This is the second edition of a book that complements Brenner and Rector's The Kidney, 7th edition (Elsevier, 2004) by covering in depth all aspects of hypertension.
Purpose: The book is intended as a reference for clinicians, scientists and healthcare planners interested in the field of vascular hypertension. It offers an in-depth discussion of all topics related to vascular hypertension, including epidemiology, clinical management, comorbidities, vascular biology, and genetics. This new release is largely updated as compared to the first edition. The book clearly meets its objectives of providing an authoritative review of the science of hypertension.
Audience: It is written for internal medicine specialists involved in the clinical management of hypertension, as well as for clinical and basic scientists with interest in this area of investigation. All authors are recognized international authorities in this field of medicine.
Features: The book covers all aspects of hypertension from a brief history of hypertension to pathophysiology, target organ damage, basic principles of management, nonpharmacological treatment, management in the presence of comorbidities, pharmacological properties of individual drugs, and finally secondary forms of hypertension and special circumstances. In general, the book has been significantly updated from the first edition, with in-depth discussion of recent large randomized clinical trials including the LIFE, VALUE, IDNT, RENAAL, and ALLHAT trials. In addition, it addresses the recent emphasis on aggressive blood-pressure control and on the global growing problems of metabolic syndrome and diabetes mellitus. The book does not shy away from discussing the interaction of science and politics in the formulation of general guidelines for management of hypertension. New topics are addressed, including the growing role of fixed combination antihypertensive agents, the emerging concept of chronotherapeutics, and the needs of hypertensive patients undergoing general anesthesia.
Assessment: This revision is an excellent addition to the currently available books on vascular hypertension. The book continues to maintain an excellent balance between exhaustive discussion of each topic and an appealing literary style. In its second edition, the book establishes itself as a prime reference in this area of medicine.
From the Publisher
REVIEW OF THE LAST EDITION:
"An in-depth, broad-based review of the basic science and clinical aspects of hypertension."—Mayo Clinic Proceedings
American Journal of Kidney Diseases
"This book is an excellent supplemtn to Brenner and Rector's The Kidney and provides an easily readable, comprehensive review of the cause, consequences, and treatment of hypertension. It can be recommended to both the student and ths scholar."
November 2006

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780721602585
  • Publisher: Elsevier Health Sciences
  • Publication date: 3/15/2005
  • Edition description: REV
  • Edition number: 2
  • Pages: 848
  • Product dimensions: 8.78 (w) x 11.26 (h) x 1.65 (d)

Table of Contents

Section 1: Background and History

1. History of Clinical Hypertension
2. The National High Blood Pressure Education Program
3. Epidemiology of Hypertension

Section 2: Pathophysiology

4. Pathophysiology of Hypertension
5. Blood Pressure Genetics
6. Sympathetic Nervous System in Acute and Chronic Blood Pressure Evaluation
7. Evironmental and Psychosocial Stress in Hypertension Onset and Progression
8. Renin
9. The Genetics of Salt-Related Hypertension
10. Angiotensin Converting Enzyme: Properties and Function
11. Angiotensin 1-7
12. The Angiotensin Receptors: AT1 and AT2
13. Aldosterone and Mineralocorticoids
14. What is the Role of Insulin Resistance and Compulsory Hyperinsulinemia in the Pathogenesis and Clinical Course of Patients with Essential Hypertension?
15. Remodelling of Resistance Arteries in Hypertension
16. Arterial Stiffness in Hypertension
17. Endothelium in Hypertension: Nitric Oxide
18. Endothelium in Hypertension: Endothelin, Prostanoids and Other Mediators.
19. The Natriuretic Peptides
20. Vasodilator Peptides: CGRP, Substance P, and Adrenomedullin
21. Kallikrein – Kinin Systems

Section 3: TargetOrgan Damage/Cardiovascular Events

22. The Concept of Total Risk
23. New Interpretations of Blood Pressure: The Importance ofPulse Pressure
24. Coronary Atherosclerotic Sequelae of Hypertension
25. Left Ventricular Hypertrophy, Congestive Heart Failure, and Coronary Flow Reserve Abnormalities in Hypertension
26. Chronic Renal Insufficiency: Slowing its Progression

Section 4: Diagnosis

27. Initial Evaluation and Follow-up Assessment
28. Prognostic and Diagnostic Value of Ambulatory Blood Pressure Monitoring
29. White Coat Hypertension

Section 5: General Consideration

30. Benefits of Treating Hypertension: The Clinical Trialists Collaborative Group
31. The Antihypertensive and Lipid-Lowering to Prevent Heart Attack Trial
32. The LIFE Study
33. The VALUE Trial
34. Clinical Outcome Trials of Hypertension with Angiotensin Receptor Blockers
35. Clinical Trials in Hypertension and Diabetes
36. ACE Inhibitor Trials: Effects in Hypertension
37. Critical Assessment of Hypertension Guidelines
38. Current Prescribing Practices
39. Calcium Channel Blockers: Controversies, Lessons and Outcomes
40. Nursing Clinics in the Management of Hypertension
41. Community Outreach
42. Medication Adherence for Antihypertensive Therapy

Section 6: Diet and Nutrition

43. Micronutrients
44. Dietary Approaches to Hypertension Management: The DASH Studies
45. Obesity and Hypertension: Effects on the Cardiovascular and Renal Systems
46. Alcohol and Hypertension
47. Obesity in Hypertension: The Role of Diet and Drugs
48. Exercise and Hypertension

Section 7:Pharmacological Treatment

49. Initial Choices in the Treatment of Hypertension
50. Pharmacokinetics of Antihypertensive Drugs
51.Fixed Combination Antihypertensive Therapy
52. Chronotherapeutics in the Treatment of Hypertension

Section 8: Comorbid Conditions and Special Populations in Hypertension

53. Diabetes Mellitis and the Cardiovascular/Metabolic Syndrome: Reducing Cardiovascular and Renal Events
54. Hypertension in Patients on Renal Replacement Therapy
55. Ischemic Heart Disease in Hypertension
56. Hypertension in the Elderly
57. Management of Hypertension in Black Populations
58. Hypertension in Pregnancy
59. Hypertension in Children
60. Resistant Hypertension
61. Orthostatic Hypotension and Autonomic Dysfunction Syndromes

Section 9: Individual Drug Classes

62. Diuretics: Mechanisms of Action
63. Beta-Adrenergic Blockers
64. Alpha-Adrenoceptor Blockers
65. Angiotensin Converting Enzyme Inhibitors
66. Calcium Antagonists
67. Angiotensin II Receptor Antagonists
68. Direct Acting Smooth Muscle Vasodilators and Adrenergic Inhibitors
69. Endothelin Antagonists
70. Mineralocorticoid Receptor Antagonists
71. Vasopeptidase Inhibitors
72. Renin Inhibitors

Section 10: Secondary Hypertension

73. Obstructive Sleep Apnea and Hypertension
74. Renovascular Hypertension: Diagnosis and Treatment
75. Adrenal Cortex Hypertension
76. Pheochromocytoma: Detection and Management
77. Anesthesia and Hypertension
78. Management of Hypertensive Emergencies and Urgencies
79. Aggressive Blood Pressure Targets: Developing Effective Algorithms

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