The Hypertrophied Heart / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $253.37
Usually ships in 1-2 business days
(Save 27%)
Other sellers (Hardcover)
  • All (2) from $253.37   
  • New (1) from $253.37   
  • Used (1) from $416.90   
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any coupons and promotions
Seller since 2007

Feedback rating:



New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

Brand New Item

Ships from: Dover, NJ

Usually ships in 1-2 business days

  • Standard, 48 States
Page 1 of 1
Showing All
Sort by


Whenever the heart is challenged with an increased workload for a prolonged period, it responds by increasing its muscle mass - a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situations such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss) and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy.
The Hypertrophied Heart compiles state-of-the-art presentations in the area of molecular biology, cellular physiology and signal transduction in cardiac hypertrophy and heart failure to help in the formulation of new concepts and approaches for stimulating research. The book contains two sections: Mechanisms of Cardiac Hypertrophy, and Cardiac Failure in the Hypertrophied Heart. It is hoped that both students and scientists, as well as clinical and experimental cardiologists, will find this book useful in understanding the molecular and cellular events underlying the development of cardiac hypertrophy and the transition from cardiac hypertrophy to heart failure.

Read More Show Less

Editorial Reviews

Doody's Review Service
Description: This compilation of the proceedings of the International Conference on Cardiac Hypertrophy held in Tokyo in October 1998 provides a comprehensive overview of hypertrophy and heart failure organized into two main sections — mechanisms of cardiac hypertrophy and cardiac failure in the hypertrophied heart.
Purpose: The book is intended to bring together reports of state-of-the-art research in cardiac hypertrophy, including cellular and molecular mechanisms in the development of hypertrophy and the transition from the hypertrophy phenotype to the failing heart. Considering the rapid advances in this active field of research, this book succeeds in bringing the reader up-to-date on many different aspects of cardiac hypertrophy research.
Audience: The editors are leaders in the field of cardiac research, and this book should be of interest to students, postdoctoral fellows, faculty, and physicians studying or practicing cardiovascular medicine.
Features: The first section focuses on changes in gene expression that serve as molecular markers of the hypertrophic response and on signal transduction mechanisms that bring about cellular changes characteristic of hypertrophied myocytes. These chapters address cellular remodeling via changes at the molecular level and also consider structural remodeling involving the cytoarchitecture. The data are largely drawn from experiments using animal models of hypertrophy employing state-of-the-art techniques. The second section attempts to establish a link between the hypertrophy phenotype and the manifestation of functional abnormalities culminating in heart failure. This section combines some basic research, again using animal models of heart failure, with clinical observations of human heart failure with respect to possible underlying causes, functional alterations, and therapeutic approaches. However, the book does not include a comprehensive discussion of widely used therapeutic drugs and how they relate to mechanisms discussed in the chapters.

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9780792377412
  • Publisher: Springer US
  • Publication date: 9/28/2000
  • Series: Progress in Experimental Cardiology Series, #3
  • Edition description: 2000
  • Edition number: 1
  • Pages: 469
  • Product dimensions: 62.50 (w) x 92.50 (h) x 1.00 (d)

Table of Contents

Dedication. Preface. Acknowledgements. A: Mechanisms of Cardiac Hypertrophy. 1. Signal Transduction in Adapted Heart: Implication of Protein Kinase C-Dependent and -Independent Pathways; J. Debarros, D.K. Das. 2. Glucose-6-Phosphate Dehydrogenase: A Marker of Cardiac Hypertrophy; H.-G. Zimmer. 3. Regulation of Ribosomal DNA Transcription During Cardiomyocyte Hypertrophy; T. Arino, et al. 4. Mihondrial Gene Expression in Hypertrophic Cardiac Muscles in Rats; T. Murakami, et al. 5. Serca2 and ANF Promoter-Activity Studies in Hypertrophic Cardiomyocytes using Liposome-, Gene Gun- and Adenovirus-Mediated Gene Transfer; K. Eizema, et al. 6. Ca2+ Transients, Contractility and Inotropic Responses in Rabbit Volume-Overload Cardiomyocytes; K. Sakurai, et al. 7. Responsiveness of Contractile Elements to Muscle Length Change in Hyperthyroid Ferret Myocardium; T. Ishikawa, et al. 8. Contraction-Dependent Hypertrophy of Neonatal Rat Ventricular Myocytes: Potential Role for Focal Adhesion Kinase; D.M. Eble, et al. 9. Molecular Mechanism of Mechanical Stress-Induced Cardiac Hypertrophy; I. Komuro. 10. Possible Roles of the Tenascin Family During Heart Development and Myocardial Tissue Remodeling; K. Imanaka-Yoshida, et al. 11. Cardiac Cell-ECM Interactions: A Possible Site for Mechanical Signaling; S. Kanekar, et al. 12. Integrin-Dependent and -Independent Signaling During Pressure Overload Cardiac Hypertrophy; M. Laser, et al. 13. Role of G-Proteins in Hypertension and Hypertrophy; M. Anand-Srivastava, F. di Fusco. 14. Three-Dimensional Nuclear Size and DNA Content in Hypertensive Heart Disease; A. Takeda, et al. 15. Age-Related Anisotropic Changes in Cardiocyte Connections in Spontaneously Hypertensive Rats; M. Okabe, et al. 16. Stimulation of Mitogen-Activated Protein Kinases ERK 1 and ERK 2 by H2O2 in Vascular Smooth Muscle Cells; A.K. Srivastava, S.K. Pandey. 17. Effects of Renin-Angiotensin System Inhibition on Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats; N. Makino, et al. 18. Adaptation of the Poikilothermic Heart to Catecholamine-Induced Overload; B. Ostadal, et al. 19. Angiogenesis and Fibrosis During Right Ventricular Hypertrophy in Human Tetralogy of Fallot; H.S. Sharma, et al. 20. Molecular Mechanisms of Phenotypic Modulation of Vascular Smooth Muscle Cells; M. Kurabayashi, R. Nagai. B: Cardiac Failure in Hypertrophied Heart. 21. Protein Kinase C Activation in Cardiac Hypertrophy and Failure; Y. Takeishi, et al. 22. Angiotensin II and Connective Tissue Homeostasis; K.T. Weber. 23. Beneficial Effects of Angiotensin Blockade in Heart Failure due to Myocardial Infarction; N.S. Dhalla, X. Guo. 24. Activated TGF-&bgr; Signaling in Heart After Myocardial Infarction; J. Hao, et al. 25. gp 130 Dependent Signaling Pathways: Recent Advances and Implications for Cardiovascular Disease; K. Yamauchi-Takihara, et al. 26. Molecular Genetic Aspects of Hypertrophic Cardiomyopathy in the Oriental; A. Kimura. 27. Hepatitis C Virus Infection in Hypertrophic or Dilated Cardiomyopathy; A. Matsumori. 28. Enhancement of Early Diastolic Filling Provoked by Dobutamine Infusion in Dilated Cardiomyopathy; S. Kurokawa, et al. 29. DNA Fragmentation is a Possible Mechanism for Heart Failure in Cardiomyopathy; Y. Sawa, et al. 30. The Difference of Phosphorylation of Desmin and Myosin Light Chain 2 in the Bio 14.6 Cardiomyopathic Heart; T. Hayakawa, et al. 31. Cardiac Remodeling in Cardiomyopathic Hamster Hearts; H. Kawaguchi. 32. Human Myocardial Na,K-ATPase in Remodeling; K. Kjeldsen. 33. Nitric Oxide Synthase Gene Transfer Inhibits Protein Synthesis of Rat Cardiac Mycocytes; U. Ikeda, et al. 34. Human Heart Failure: A Mechanistic Assessment of Altered Ventricular Function; N.R. Alpert, L.A. Mulieri. 35. The Structural Correlate of Reduced Cardiac Function in Failing Human Hearts; S. Kostin. 36. Diastolic Dysfunction and Diastolic Heart Failure; K. Yamamoto, et al. 37. Effects of Melatonin on Cardiac Function and Metabolism in the Ischemic Working Rat Heart; K.-I. Masui, et al.
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)