The Hypertrophied Heart / Edition 1

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2000 Hardback NEAR FINE Hardback, This listing is a new book, a title currently in-print which we order directly and immediately from the publisher. *****PLEASE NOTE: This item ... is shipping from an authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Overview

Whenever the heart is challenged with an increased workload for a prolonged period, it responds by increasing its muscle mass - a phenomenon known as cardiac hypertrophy. Although cardiac hypertrophy is commonly seen under physiological conditions such as development and exercise, a wide variety of pathological situations such as hypertension (pressure overload), valvular defects (volume overload), myocardial infarction (muscle loss) and cardiomyopathy (muscle disease) are also known to result in cardiac hypertrophy.
The Hypertrophied Heart compiles state-of-the-art presentations in the area of molecular biology, cellular physiology and signal transduction in cardiac hypertrophy and heart failure to help in the formulation of new concepts and approaches for stimulating research. The book contains two sections: Mechanisms of Cardiac Hypertrophy, and Cardiac Failure in the Hypertrophied Heart. It is hoped that both students and scientists, as well as clinical and experimental cardiologists, will find this book useful in understanding the molecular and cellular events underlying the development of cardiac hypertrophy and the transition from cardiac hypertrophy to heart failure.

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Editorial Reviews

Doody's Review Service
Reviewer:
Description: This compilation of the proceedings of the International Conference on Cardiac Hypertrophy held in Tokyo in October 1998 provides a comprehensive overview of hypertrophy and heart failure organized into two main sections — mechanisms of cardiac hypertrophy and cardiac failure in the hypertrophied heart.
Purpose: The book is intended to bring together reports of state-of-the-art research in cardiac hypertrophy, including cellular and molecular mechanisms in the development of hypertrophy and the transition from the hypertrophy phenotype to the failing heart. Considering the rapid advances in this active field of research, this book succeeds in bringing the reader up-to-date on many different aspects of cardiac hypertrophy research.
Audience: The editors are leaders in the field of cardiac research, and this book should be of interest to students, postdoctoral fellows, faculty, and physicians studying or practicing cardiovascular medicine.
Features: The first section focuses on changes in gene expression that serve as molecular markers of the hypertrophic response and on signal transduction mechanisms that bring about cellular changes characteristic of hypertrophied myocytes. These chapters address cellular remodeling via changes at the molecular level and also consider structural remodeling involving the cytoarchitecture. The data are largely drawn from experiments using animal models of hypertrophy employing state-of-the-art techniques. The second section attempts to establish a link between the hypertrophy phenotype and the manifestation of functional abnormalities culminating in heart failure. This section combines some basic research, again using animal models of heart failure, with clinical observations of human heart failure with respect to possible underlying causes, functional alterations, and therapeutic approaches. However, the book does not include a comprehensive discussion of widely used therapeutic drugs and how they relate to mechanisms discussed in the chapters.
Assessment:

3 Stars from Doody
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Product Details

  • ISBN-13: 9780792377412
  • Publisher: Springer US
  • Publication date: 9/28/2000
  • Series: Progress in Experimental Cardiology Series , #3
  • Edition description: 2000
  • Edition number: 1
  • Pages: 469
  • Product dimensions: 62.50 (w) x 92.50 (h) x 1.00 (d)

Table of Contents

Dedication. Preface. Acknowledgements. A: Mechanisms of Cardiac Hypertrophy. 1. Signal Transduction in Adapted Heart: Implication of Protein Kinase C-Dependent and -Independent Pathways; J. Debarros, D.K. Das. 2. Glucose-6-Phosphate Dehydrogenase: A Marker of Cardiac Hypertrophy; H.-G. Zimmer. 3. Regulation of Ribosomal DNA Transcription During Cardiomyocyte Hypertrophy; T. Arino, et al. 4. Mihondrial Gene Expression in Hypertrophic Cardiac Muscles in Rats; T. Murakami, et al. 5. Serca2 and ANF Promoter-Activity Studies in Hypertrophic Cardiomyocytes using Liposome-, Gene Gun- and Adenovirus-Mediated Gene Transfer; K. Eizema, et al. 6. Ca2+ Transients, Contractility and Inotropic Responses in Rabbit Volume-Overload Cardiomyocytes; K. Sakurai, et al. 7. Responsiveness of Contractile Elements to Muscle Length Change in Hyperthyroid Ferret Myocardium; T. Ishikawa, et al. 8. Contraction-Dependent Hypertrophy of Neonatal Rat Ventricular Myocytes: Potential Role for Focal Adhesion Kinase; D.M. Eble, et al. 9. Molecular Mechanism of Mechanical Stress-Induced Cardiac Hypertrophy; I. Komuro. 10. Possible Roles of the Tenascin Family During Heart Development and Myocardial Tissue Remodeling; K. Imanaka-Yoshida, et al. 11. Cardiac Cell-ECM Interactions: A Possible Site for Mechanical Signaling; S. Kanekar, et al. 12. Integrin-Dependent and -Independent Signaling During Pressure Overload Cardiac Hypertrophy; M. Laser, et al. 13. Role of G-Proteins in Hypertension and Hypertrophy; M. Anand-Srivastava, F. di Fusco. 14. Three-Dimensional Nuclear Size and DNA Content in Hypertensive Heart Disease; A. Takeda, et al. 15. Age-Related Anisotropic Changes in Cardiocyte Connections in Spontaneously Hypertensive Rats; M. Okabe, et al. 16. Stimulation of Mitogen-Activated Protein Kinases ERK 1 and ERK 2 by H2O2 in Vascular Smooth Muscle Cells; A.K. Srivastava, S.K. Pandey. 17. Effects of Renin-Angiotensin System Inhibition on Cardiac Hypertrophy and Fibrosis in Spontaneously Hypertensive Rats; N. Makino, et al. 18. Adaptation of the Poikilothermic Heart to Catecholamine-Induced Overload; B. Ostadal, et al. 19. Angiogenesis and Fibrosis During Right Ventricular Hypertrophy in Human Tetralogy of Fallot; H.S. Sharma, et al. 20. Molecular Mechanisms of Phenotypic Modulation of Vascular Smooth Muscle Cells; M. Kurabayashi, R. Nagai. B: Cardiac Failure in Hypertrophied Heart. 21. Protein Kinase C Activation in Cardiac Hypertrophy and Failure; Y. Takeishi, et al. 22. Angiotensin II and Connective Tissue Homeostasis; K.T. Weber. 23. Beneficial Effects of Angiotensin Blockade in Heart Failure due to Myocardial Infarction; N.S. Dhalla, X. Guo. 24. Activated TGF-&bgr; Signaling in Heart After Myocardial Infarction; J. Hao, et al. 25. gp 130 Dependent Signaling Pathways: Recent Advances and Implications for Cardiovascular Disease; K. Yamauchi-Takihara, et al. 26. Molecular Genetic Aspects of Hypertrophic Cardiomyopathy in the Oriental; A. Kimura. 27. Hepatitis C Virus Infection in Hypertrophic or Dilated Cardiomyopathy; A. Matsumori. 28. Enhancement of Early Diastolic Filling Provoked by Dobutamine Infusion in Dilated Cardiomyopathy; S. Kurokawa, et al. 29. DNA Fragmentation is a Possible Mechanism for Heart Failure in Cardiomyopathy; Y. Sawa, et al. 30. The Difference of Phosphorylation of Desmin and Myosin Light Chain 2 in the Bio 14.6 Cardiomyopathic Heart; T. Hayakawa, et al. 31. Cardiac Remodeling in Cardiomyopathic Hamster Hearts; H. Kawaguchi. 32. Human Myocardial Na,K-ATPase in Remodeling; K. Kjeldsen. 33. Nitric Oxide Synthase Gene Transfer Inhibits Protein Synthesis of Rat Cardiac Mycocytes; U. Ikeda, et al. 34. Human Heart Failure: A Mechanistic Assessment of Altered Ventricular Function; N.R. Alpert, L.A. Mulieri. 35. The Structural Correlate of Reduced Cardiac Function in Failing Human Hearts; S. Kostin. 36. Diastolic Dysfunction and Diastolic Heart Failure; K. Yamamoto, et al. 37. Effects of Melatonin on Cardiac Function and Metabolism in the Ischemic Working Rat Heart; K.-I. Masui, et al.
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