ICRF Handbook of Genome Analysis, 2-Volume Set / Edition 1

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Overview

The combined power of genetic analysis and recombinant DNA technology to analyse entire genomes has moved biomedical research into a new and revolutionary phase. The complete sequencing and mapping of the human genome, as well as the genomes of other model organisms, will be the basis for our future understanding of human disease, and will allow us to answer fundamental questions about development and evolution. T

The new ICRF Handbook of Genome Analysis is the essential guide to the enormous range of techniques available to the researcher for both the genetic and physical mapping of the genome, as well as the sequencing and analysis of DNA. It is both a protocol manual and a comprehensive information resource. Written by international experts, each chapter presents a state-of-the-art review of a methodology. Methods are fully described and evaluated; their advantages and disadvantages discussed; and their suitability for different investigations considered. Step-by-step protocols, including computer analyses, are given for 123 essential experimental procedures. 'Troubleshooting' sections discuss possible reasons for failure and offer remedies. The primary focus is on human genetics and the benefits of an understanding of the genome for the diagnosis and treatment of human disease. The book also considers the current state of progress in the analysis of genomes of many model organisms, including plants. A major part of the work provides detail on Internet resources as well as basic data on human and other genomes, including mapped disease genes and mouse knockouts.

  • Covers not only the human genome in relation to cancers and other human diseases, but also the genomes of all important model organisms
  • Contains 123 easy-to-follow protocols for essential experimental procedures
  • Reviews a vast range of other information resources, including journals and the Internet
    • provides an invaluable listing of suppliers of laboratory materials
  • Has been written by international experts from their own practical experience
  • Is mandated by the Imperial Cancer Research Fund - a leader in research in this field
  • Has a sturdy spiral binding within a hardback case for ease of use in the lab

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Michael Cummings
This book is a combination of protocols and review articles providing a comprehensive overview of genome analysis. Rapid advances in genomics have generated a range of new techniques. This book describes in detail and evaluates over 120 protocols related to genome analysis. It is intended for anyone doing laboratory research on genomics, from established researchers and clinicians to beginning graduate students. In addition to standard protocols for cell culture, DNA fingerprinting, and library construction, newer methods such as the use of magnetic beads for DNA purification are covered. Each protocol is written by leading authorities in the field. Chapters 1 to 19 cover methods in genetics and physical mapping; Chapters 20 to 25 cover approaches to DNA sequencing; Chapters 26 to 34 reviews genome projects; and Chapters 35 to 37 cover informatics and Internet resources. Appendixes contain a wealth of information, including materials and suppliers; tables of mapped human disease genes; mouse knockouts; and chromosomal aberrations associated with cancer. The illustrations are a combination of black-and-white and color photographs and are of good quality. The volumes are large format notebooks with spiral bindings designed for use at the lab bench. Each protocol is organized with a list of materials, a step-by-step set of methods, and a troubleshooting section with suggestions for resolving problems, and often, references to examples of good results in the literature. Although many excellent manuals of genomics protocols have been published in recent years, this set stands out for its organization, format, and comprehensive coverage. It should be in libraries and on the lab benchof anyone doing genomics research.
From The Critics
Reviewer:Michael Cummings, PhD (University of Illinois at Chicago)
Description:This book is a combination of protocols and review articles providing a comprehensive overview of genome analysis.
Purpose:Rapid advances in genomics have generated a range of new techniques. This book describes in detail and evaluates over 120 protocols related to genome analysis.
Audience:It is intended for anyone doing laboratory research on genomics, from established researchers and clinicians to beginning graduate students.
Features:In addition to standard protocols for cell culture, DNA fingerprinting, and library construction, newer methods such as the use of magnetic beads for DNA purification are covered. Each protocol is written by leading authorities in the field. Chapters 1 to 19 cover methods in genetics and physical mapping; Chapters 20 to 25 cover approaches to DNA sequencing; Chapters 26 to 34 reviews genome projects; and Chapters 35 to 37 cover informatics and Internet resources. Appendixes contain a wealth of information, including materials and suppliers; tables of mapped human disease genes; mouse knockouts; and chromosomal aberrations associated with cancer. The illustrations are a combination of black-and-white and color photographs and are of good quality. The volumes are large format notebooks with spiral bindings designed for use at the lab bench. Each protocol is organized with a list of materials, a step-by-step set of methods, and a troubleshooting section with suggestions for resolving problems, and often, references to examples of good results in the literature.
Assessment:Although many excellentmanuals of genomics protocols have been published in recent years, this set stands out for its organization, format, and comprehensive coverage. It should be in libraries and on the lab bench of anyone doing genomics research.
Booknews
A two-volume combination protocol manual and informational resource which describes and evaluates a wide range of techniques pertinent to genome analysis. Each volume contains 37 chapters and nine appendices. Volume I comprises a description and evaluation of strategies, techniques and protocols for use in the genetic and physical mapping of the human genome and some of the applications of these techniques. Volume II presents a comprehensive review section of approaches to DNA sequencing, reviews of progress in the analysis of the genomes of important model systems, and information resources and how to access them. An index to the complete handbook is included at the end of each volume. Spiral wire binding. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780632037285
  • Publisher: Wiley
  • Publication date: 3/31/1998
  • Format: Spiral Bound
  • Edition description: SPIRAL
  • Edition number: 1
  • Pages: 1088
  • Product dimensions: 10.00 (w) x 13.10 (h) x 3.40 (d)

Table of Contents

Introduction.

Family Studies.

Complex Studies.

Constructing And Using Genetic Maps.

Automated Map Construction.

Polymorphic Markers.

DNA Typing.

Part II: Physical Mapping I: Cytogenetic Analysis.

Introduction.

Conventional Cytogenetics.

Solid Tumor Cytogenetics.

In Situ Hybridisation.

Chromosome Painting.

Chromosome Microdissection.

Chromosome Sorting And Analysis.

Digital Microscopy.

Part III: Physical Mapping II: Long-Range Mapping And Gene Isolation.

Introduction.

Somatic Cell Hybrid Approaches To Genome Mapping.

Long-Range Physical Mapping.

Integrating Genetic And Physical Maps.

Strategies For Rapid Isolation Of Genes From Genomic DNA:Cdna Techniques Screening Cdna Libraries By Transient Expression In Mammalian Cells.

Part IV: Sequencing And Sequence Analysis.

Introduction.

Sequencing Strategies.

Template Amplification And Purification.

Sequencing Chemistries.

Electrophoresis.

Sequence Labelling And Detection.

Automation.

Mutation Analysis.

Repeat Analysis.

Part V: Other Model Systems.

Introduction.

Mouse Mapping.

Somatic Gene Therapy.

Drosophila Melanogaster.

Caenorhabditis Elegan.

Saccharomyces Cerevisiae.

Escherichia Coli.

Problems In Plant Genome Analysis.

Arabidopsis Thaliana.

Part VI: Internet Resources.

Introduction.

Internet Resources And How To Use Them.

Unix Survival Kit.

Databases And Genome Resource Centers.

Appendices.

Materials, Media And Solutions.

Preparation Of Blood Bottles And Processing Of Blood Samples.

Commercial Suppliers.

Other Resources.

Useful Addresses And Internet Connections.

Basic Data On Human And Other Genomes.

Catalogue Of Mapped Human Disease Genes.

Mouse Gene Knock-Out Tables.

Chromosome Aberrations Associated With Cancer.

Glossary.

Index.

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