Immune Dysfunction and Immunotherapy in Heart Disease / Edition 1

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Overview

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction. The outstanding editor team of two internationally recognized immunologists - Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.

The four parts of the book address: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes, Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs, Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs, Immune Dysfunction Leading to Heart Disease: Induction by Pathogens. Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

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Product Details

  • ISBN-13: 9781405155687
  • Publisher: Wiley
  • Publication date: 9/28/2007
  • Edition number: 1
  • Pages: 328
  • Product dimensions: 7.35 (w) x 10.30 (h) x 0.80 (d)

Meet the Author

Dr. Larson and Dr. Watson have worked together researching the role of immune and cytokine dysfunction in heart disease for 8 years. They have been and currently are funded to do such research by grants from the U.S. National Institute of Heart, Lung and Blood, the American Heart Foundation, companies and private foundations. Dr. Watson has edited 62 scientific books, including several dealing with heart disease and conditions such as aging and AIDS that promote immune dysfunction as well as heart disease. Dr. Larson directs the Center’s organ perfusion program as well as its Master degree in pharmacology and toxicology for perfusion students.

____________________________________________________________________

Ronald Ross Watson Ph.D.

Professor Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245155, 1501 N. Campbell Avenue, Tucson, AZ 85749.

(520) 626 2850, Fax (520) 626 6093 rwatson@u.arizona.edu

____________________________________________________________________

Douglas F. Larson Ph.D.

Professor Surgery and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell Avenue, Tucson, AZ 85749. (520) 626 6494 dflarson@email.arizona.edu

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Table of Contents


Contributors     vii
Preface     xi
About the Editors     xiii
Immune dysfunction leading to heart disease: induction by physiological changes     1
Immunosuppression by ultraviolet light-B radiation: a mediator of cardiac remodeling   Sherma Zibadi   Douglas F. Larson   Ronald Ross Watson     3
Immune mechanisms in pediatric cardiovascular disease   Wendy A. Luce   Mandar S. Joshi   Timothy M. Hoffman   Timothy F. Feltes   John Anthony Bauer     6
Heart failure-role of autoimmunity   Urs Eriksson     17
Immune basis of hypertension in humans   Katherine Horak   Douglas F. Larson     28
Immune dysregulation: potential mediator of metabolic syndrome-induced cardiac remodeling   Sherma Zibadi   Douglas F. Larson   Ronald Ross Watson     34
T helper 2 cell cytokines in remodeling of aortic wall   W. L Chan     39
Effects of TNF-[alpha] on cardiac function   Bo Yang   Douglas F. Larson     48
Immunosuppression in promotion of cardiac allograft vasculopathy   Farzad Moien-Afshari   Jonathan Choy   Bruce M. McManus   Ismail Laher     57
Immunotherapy forleft ventricular dysfunction after heart transplantation   Charles E. Canter     80
Immune dysfunction promoting CVD: induction by transplantation drugs     95
Immunomodulating therapy in chronic heart failure   Lars Gullestad   Jan Kristian Damas   Arne Yndestad   Pal Aukrust     97
Statins in atherosclerosis: role of immune regulation   Claire Arnaud   Francois Mach     109
ACE inhibitors as immunomodulators: treatment of cardiovascular disease   Christina Grothusen   Bernhard Schieffer     116
Treatment of heart failure by anticytokine therapies   Donna L. Vredevoe   Julia R. Gage     128
Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugs     133
Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndrome   Giuseppe Barbaro     135
Cytokines and T cell-mediated responses in autoimmune myocarditis   Jin Zhang     152
Drugs of abuse: accentuation of immunomodulation of viral myocarditis   Oana Madalina Petrescu   James P. Morgan     157
Immune dysfunction leading to heart disease: induction by pathogens     173
Osteopontin: the link between the immune system and cardiac remodeling    Samira Najmaii   Qianli Yu   Douglas F. Larson     175
Inflammatory immune activation in heart failure patients: therapeutic implications   Mohammad Abraham Kazemizadeh Gol   Mohsen Araghi-Niknam     182
Role of innate immune dysregulation in diabetic heart failure   Betsy B. Dokken   Paul F. McDonagh     186
Tolerance in heart transplantation: current and future role   Kimberly Gandy   Jos Domen   Jack Copeland     195
Neutralization of Th2 cytokines in therapy of cardiovascular pathology   A. Mandel   A. E. Bolton     207
Anti-inflammatory immune therapy in heart disease   David Chen   Christian Assad-Kottner   Francisco J. Cordova   Carlos Orrego   Guillermo Torre-Amione     217
Cholesterol, interleukin-6 inflammation, and atherosclerosis-role of statins, bisphosphonates, and plant polyphenols in atherosclerosis and other diseases of aging   Sota Omoigui     227
Autoimmune myocarditis: treatment with anti-T-cell antibodies   Zofia T. Bilinska   Witold Ruzytto     256
Immunosuppressive therapy to counter cardiac allograft vasculopathy   Carl V. Leier     263
Role of oral pathogens in the pathogenesis of coronary heart disease   Palle Holmstrup     271
Myocardial regenerative potential by stem cell transplant   Yinhong Chen   Catherine A. Priest   Joseph D. Gold     280
Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseases   Simin Bolourchi-Vaghefi   Amy Galena     288
Index     301
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