Immune Dysfunction and Immunotherapy in Heart Disease / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $60.85
Usually ships in 1-2 business days
(Save 70%)
Other sellers (Hardcover)
  • All (8) from $60.85   
  • New (4) from $163.92   
  • Used (4) from $60.85   


Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction. The outstanding editor team of two internationally recognized immunologists - Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.

The four parts of the book address: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes, Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs, Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs, Immune Dysfunction Leading to Heart Disease: Induction by Pathogens. Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Read More Show Less

Product Details

  • ISBN-13: 9781405155687
  • Publisher: Wiley
  • Publication date: 9/28/2007
  • Edition number: 1
  • Pages: 328
  • Product dimensions: 7.35 (w) x 10.30 (h) x 0.80 (d)

Meet the Author

Dr. Larson and Dr. Watson have worked together researching the role of immune and cytokine dysfunction in heart disease for 8 years. They have been and currently are funded to do such research by grants from the U.S. National Institute of Heart, Lung and Blood, the American Heart Foundation, companies and private foundations. Dr. Watson has edited 62 scientific books, including several dealing with heart disease and conditions such as aging and AIDS that promote immune dysfunction as well as heart disease. Dr. Larson directs the Center’s organ perfusion program as well as its Master degree in pharmacology and toxicology for perfusion students.


Ronald Ross Watson Ph.D.

Professor Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245155, 1501 N. Campbell Avenue, Tucson, AZ 85749.

(520) 626 2850, Fax (520) 626 6093


Douglas F. Larson Ph.D.

Professor Surgery and the Sarver Heart Center in the School of Medicine, University of Arizona, P. O. Box 245066, 1501 N. Campbell Avenue, Tucson, AZ 85749. (520) 626 6494

Read More Show Less

Table of Contents

Contributors     vii
Preface     xi
About the Editors     xiii
Immune dysfunction leading to heart disease: induction by physiological changes     1
Immunosuppression by ultraviolet light-B radiation: a mediator of cardiac remodeling   Sherma Zibadi   Douglas F. Larson   Ronald Ross Watson     3
Immune mechanisms in pediatric cardiovascular disease   Wendy A. Luce   Mandar S. Joshi   Timothy M. Hoffman   Timothy F. Feltes   John Anthony Bauer     6
Heart failure-role of autoimmunity   Urs Eriksson     17
Immune basis of hypertension in humans   Katherine Horak   Douglas F. Larson     28
Immune dysregulation: potential mediator of metabolic syndrome-induced cardiac remodeling   Sherma Zibadi   Douglas F. Larson   Ronald Ross Watson     34
T helper 2 cell cytokines in remodeling of aortic wall   W. L Chan     39
Effects of TNF-[alpha] on cardiac function   Bo Yang   Douglas F. Larson     48
Immunosuppression in promotion of cardiac allograft vasculopathy   Farzad Moien-Afshari   Jonathan Choy   Bruce M. McManus   Ismail Laher     57
Immunotherapy forleft ventricular dysfunction after heart transplantation   Charles E. Canter     80
Immune dysfunction promoting CVD: induction by transplantation drugs     95
Immunomodulating therapy in chronic heart failure   Lars Gullestad   Jan Kristian Damas   Arne Yndestad   Pal Aukrust     97
Statins in atherosclerosis: role of immune regulation   Claire Arnaud   Francois Mach     109
ACE inhibitors as immunomodulators: treatment of cardiovascular disease   Christina Grothusen   Bernhard Schieffer     116
Treatment of heart failure by anticytokine therapies   Donna L. Vredevoe   Julia R. Gage     128
Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugs     133
Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndrome   Giuseppe Barbaro     135
Cytokines and T cell-mediated responses in autoimmune myocarditis   Jin Zhang     152
Drugs of abuse: accentuation of immunomodulation of viral myocarditis   Oana Madalina Petrescu   James P. Morgan     157
Immune dysfunction leading to heart disease: induction by pathogens     173
Osteopontin: the link between the immune system and cardiac remodeling    Samira Najmaii   Qianli Yu   Douglas F. Larson     175
Inflammatory immune activation in heart failure patients: therapeutic implications   Mohammad Abraham Kazemizadeh Gol   Mohsen Araghi-Niknam     182
Role of innate immune dysregulation in diabetic heart failure   Betsy B. Dokken   Paul F. McDonagh     186
Tolerance in heart transplantation: current and future role   Kimberly Gandy   Jos Domen   Jack Copeland     195
Neutralization of Th2 cytokines in therapy of cardiovascular pathology   A. Mandel   A. E. Bolton     207
Anti-inflammatory immune therapy in heart disease   David Chen   Christian Assad-Kottner   Francisco J. Cordova   Carlos Orrego   Guillermo Torre-Amione     217
Cholesterol, interleukin-6 inflammation, and atherosclerosis-role of statins, bisphosphonates, and plant polyphenols in atherosclerosis and other diseases of aging   Sota Omoigui     227
Autoimmune myocarditis: treatment with anti-T-cell antibodies   Zofia T. Bilinska   Witold Ruzytto     256
Immunosuppressive therapy to counter cardiac allograft vasculopathy   Carl V. Leier     263
Role of oral pathogens in the pathogenesis of coronary heart disease   Palle Holmstrup     271
Myocardial regenerative potential by stem cell transplant   Yinhong Chen   Catherine A. Priest   Joseph D. Gold     280
Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseases   Simin Bolourchi-Vaghefi   Amy Galena     288
Index     301
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)